Cited by 173Attention Deficit Hyperactivity DisorderNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

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ADHD‐ and medication‐related brain activation effects in concordantly affected parent–child dyads with ADHD

Epstein, Jeffery N., Casey, B.J., Tonev, Simon T., Davidson, Matthew C., Reiss, Allan L., Garrett, Amy, Hinshaw, Stephen P., Greenhill, Laurence L., Glover, Gary, Shafritz, Keith M., Vitolo, Alan, Kotler, Lisa A., Jarrett, Matthew A., Spicer, Julie·2007·Journal of Child Psychology and Psychiatry

DOI 10.1111/j.1469-7610.2007.01761.x

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Abstract

BACKGROUND: Several studies have documented fronto-striatal dysfunction in children and adolescents with attention deficit/hyperactivity disorder (ADHD) using response inhibition tasks. Our objective was to examine functional brain abnormalities among youths and adults with ADHD and to examine the relations between these neurobiological abnormalities and response to stimulant medication. METHOD: A group of concordantly diagnosed ADHD parent-child dyads was compared to a matched sample of normal parent-child dyads. In addition, ADHD dyads were administered double-blind methylphenidate and placebo in a counterbalanced fashion over two consecutive days of testing. Frontostriatal function was measured using functional magnetic resonance imaging (fMRI) during performance of a go/no-go task. RESULTS: Youths and adults with ADHD showed attenuated activity in fronto-striatal regions. In addition, adults with ADHD appeared to activate non-fronto-striatal regions more than normals. A stimulant medication trial showed that among youths, stimulant medication increased activation in fronto-striatal and cerebellar regions. In adults with ADHD, increases in activation were observed in the striatum and cerebellum, but not in prefrontal regions. CONCLUSIONS: This study extends findings of fronto-striatal dysfunction to adults with ADHD and highlights the importance of frontostriatal and frontocerebellar circuitry in this disorder, providing evidence of an endophenotype for examining the genetics of ADHD.

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Authors: Epstein, J. N., Casey, B. J., Tonev, S. T., Davidson, M. C., Reiss, A. L., Garrett, A., Hinshaw, S. P., Greenhill, L. L., Glover, G., Shafritz, K. M., Vitolo, A., Kotler, L. A., Jarrett, M. A., & Spicer, J.
Affiliations: Cincinnati Children's Hospital Medical Center (US)
Cornell University (US)
Duke Medical Center (US)
Stanford Medicine (US)
University of California, Berkeley (US)
Columbia University Irving Medical Center (US)
Hofstra University (US)
Corresponding author: Epstein, Jeffery N.
ORCID: Epstein, Jeffery N.
Casey, B.J.
Reiss, Allan L.
Garrett, Amy
Hinshaw, Stephen P.
Greenhill, Laurence L.
Glover, Gary
Shafritz, Keith M.
Jarrett, Matthew A.
Spicer, Julie
Venue: Journal of Child Psychology and Psychiatry
Publisher: Wiley
Published: 2007-08-09
Volume: 48
Issue: 9
Pages: 899-913
ISSN: 0021-9630 (ISSN-L)
1469-7610
DOI: 10.1111/j.1469-7610.2007.01761.x
OpenAlex: W1832744912
Cited by: 173
References: 65
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 25 · 2013: 20 · 2012: 15
FWCI: 7.64
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Child Psychology and Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH064166, R01MH064177, MH064182, K24MH064478, MH064177, R01MH064179, MH064166, R01MH064182, MH064179, MH064176, R01MH064176)
National Center for Research Resources (RR 09784, P41RR009784)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: attention deficit hyperactivity disorder, frontostriatal dysfunction, response inhibition, go/no-go task, methylphenidate, stimulant medication response, cerebellum, parent-child dyads, adult ADHD, endophenotypes, striatum
MeSH terms: Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Brain, Child, Double-Blind Method, Female, Humans, Magnetic Resonance Imaging, Male, Methylphenidate, Parent-Child Relations

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ADHD‐ and medication‐related brain activation effects in concordantly affected parent–child dyads with ADHD

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