The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Spontaneous electrical rhythmicity in cultured interstitial cells of Cajal from the murine small intestine
Open accessAbstract
Interstitial cells of Cajal (ICC) are pacemaker cells in the small bowel, and therefore this cell type must express the mechanism responsible for slow wave activity. Isolated ICC were cultured for 1–3 days from the murine small intestine and identified with c‐Kit‐like immunoreactivity (c‐Kit‐LI). Electrical recordings were obtained from cultured ICC with the whole‐cell patch clamp technique. ICC were rhythmically active, producing regular slow wave depolarizations with waveforms and properties similar to slow waves in intact tissues. Spontaneous activity of c‐Kit‐LI cells was inhibited by reduced extracellular Na+, gadolinium, and reduced extracellular Ca 2+. The activity was not affected by nisoldipine. Voltage clamp studies showed rhythmic inward currents that were probably responsible for the slow wave activity. The current‐voltage relationship showed that the spontaneous currents reversed at about +17 mV. These observations are consistent with the involvement of a non‐selective cation current in the generation of slow waves, but do not rule out contributions from other conductances or transporters. A Ba 2+‐sensitive inwardly rectifying K+ current in c‐Kit‐LI cells that may be involved in slow wave repolarization and maintenance of a negative potential between slow waves was also found. Similar pharmacology was observed in studies of intact murine intestinal muscles. Cultured ICC may be a useful model for studying the properties and pharmacology of some of the ionic conductances involved in spontaneous rhythmicity in the gastrointestinal tract.
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W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity
Hulzinga, J. D., Thuneberg, L., Klüppel, M., Malysz, J., Mikkelsen, H. B., & Bernstein, A. (1995) · Nature · doi:10.1038/373347a0 · Cited by 1,400
Lee, J. H., Kim, S.-Y., Kwon, Y. K., Kim, B. J., & So, I. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350075 · Cited by 1,380
Sanders, K. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8690216 · Cited by 959
Self-citationKim, B. J., Nam, J. H., Kim, K. H., Joo, M., Ha, T. S., Weon, K. Y., Choi, S., Jun, J. Y., Park, E. J., Wie, J., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000366306 · Cited by 886
Ward, S. M., Burns, A. J., Torihashi, S., & Sanders, K. M. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020343 · Cited by 809
Self-citationPhysiology of the Gastrointestinal Tract
Gross, J. B. (1988) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65119-2 · Cited by 704
Nishikawa, S., Kusakabe, M., Yoshinaga, K., Ogawa, M., Hayashi, S., Kunisada, T., Era, T., Sakakura, T., & Nishikawa, S. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07744.x · Cited by 465
Torihashi, S., Ward, S. M., Nishikawa, S.-I., Nishi, K., Kobayashi, S., & Sanders, K. M. (1995) · Cell and Tissue Research · doi:10.1007/bf00304515 · Cited by 407
Self-citationSpontaneous electrical activity of interstitial cells of Cajal isolated from canine proximal colon.
Langton, P., Ward, S. M., Carl, A., Norell, M. A., & Sanders, K. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7280 · Cited by 247
Self-citationBurns, A. J., Herbert, T. M., Ward, S. M., & Sanders, K. M. (1997) · Cell and Tissue Research · doi:10.1007/s004410050902 · Cited by 202
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Cited by
INTERSTITIAL CELLS OF CAJAL AS PACEMAKERS IN THE GASTROINTESTINAL TRACT
Sanders, K. M., Koh, S. D., & Ward, S. M. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040504.094718 · Cited by 619
Self-citationInterstitial Cells: Regulators of Smooth Muscle Function
Sanders, K. M., Ward, S. M., & Koh, S. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00037.2013 · Cited by 498
Self-citationGut peristalsis is governed by a multitude of cooperating mechanisms
Huizinga, J. D., & Lammers, W. J. E. P. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90380.2008 · Cited by 386
Development and plasticity of interstitial cells of Cajal
Sanders, Ördög, Koh, Torihashi, & Ward (1999) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1999.00164.x · Cited by 317
Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility
Foong, D., Zhou, J., Zarrouk, A., Ho, V., & O’Connor, M. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124540 · Cited by 127
Metadata
- Authors
- Koh, S. D., Sanders, K. M., & Ward, S. M.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1998-11
- Volume
- 513
- Issue
- 1
- Pages
- 203-213
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2056614650
- Cited by
- 261
- References
- 13
- FWCI
- 13.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Koh, S. D., Sanders, K. M., & Ward, S. M. (1998). Spontaneous electrical rhythmicity in cultured interstitial cells of Cajal from the murine small intestine. The Journal of Physiology. https://doi.org/10.1111/j.1469-7793.1998.203by.x
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