The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Spontaneous electrical activity of interstitial cells of Cajal isolated from canine proximal colon.
Open accessAbstract
Interstitial cells of Cajal (ICC) have been suggested as pacemaker cells in the gastrointestinal tract. A method was developed to isolate ICC from the slow-wave pacemaker region of the canine proximal colon. These cells were identified under phase-contrast microscopy, and their identity was verified by comparing their ultrastructure with the morphology of ICC in situ. Patch-clamp experiments demonstrated that these cells are excitable; voltage-dependent inward and outward currents were elicited by depolarization. Inward current transients were identified as calcium currents. A portion of the outward current appears to be due to Ca2+-activated K channels commonly expressed in these cells. ICC were also spontaneously active, generating electrical depolarizations similar in waveform to slow-wave events of intact colonic muscles. These findings are consistent with the hypothesis that ICC initiate rhythmicity in the colon.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Suzuki, N., Prosser, C. L., & Dahms, V. (1986) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1986.250.3.g287 · Cited by 125
Cited by
Requirement of c-kit for development of intestinal pacemaker system
Maeda, H., Yamagata, A., Nishikawa, S., Yoshinaga, K., Kobayashi, S., Nishi, K., & Nishikawa, S.-I. (1992) · Development · doi:10.1242/dev.116.2.369 · Cited by 697
INTERSTITIAL CELLS OF CAJAL AS PACEMAKERS IN THE GASTROINTESTINAL TRACT
Sanders, K. M., Koh, S. D., & Ward, S. M. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040504.094718 · Cited by 619
Self-citationInterstitial Cells: Regulators of Smooth Muscle Function
Sanders, K. M., Ward, S. M., & Koh, S. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00037.2013 · Cited by 498
Self-citationDevelopment and plasticity of interstitial cells of Cajal
Sanders, Ördög, Koh, Torihashi, & Ward (1999) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1999.00164.x · Cited by 317
Koh, S. D., Sanders, K. M., & Ward, S. M. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.203by.x · Cited by 261
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Metadata
- Authors
- Langton, P., Ward, S. M., Carl, A., Norell, M. A., & Sanders, K. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-09
- Volume
- 86
- Issue
- 18
- Pages
- 7280-7284
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048142140
- Cited by
- 247
- References
- 2
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Langton, P., Ward, S. M., Carl, A., Norell, M. A., & Sanders, K. M. (1989). Spontaneous electrical activity of interstitial cells of Cajal isolated from canine proximal colon. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.18.7280
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