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Cited by 85Birth, Development, and HealthPancreatic function and diabetesReproductive Physiology in Livestock

Developmental regulation of glucogenesis in the sheep fetus during late gestation

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Fowden, Abigail L., Mundy, Linda, the late Silver, Marian·1998·The Journal of Physiology
DOI 10.1111/j.1469-7793.1998.937bp.xPMC PMC2230917
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Abstract

Using tracer methodology, endogenous glucose production was measured in twenty‐six chronically catheterized sheep fetuses during normal fed conditions and in response to a 48 h period of maternal fasting at different gestational ages during the last 10‐15 days of gestation (term, 145 ± 2 days). In normal fed conditions, the rate of fetal glucose production was negligible until 143‐145 days when it rose significantly to account for 50 % of the glucose used by the fetus. The rise in fetal glucogenesis towards term closely parallelled the normal prepartum rise in fetal plasma cortisol and catecholamines. Maternal fasting for 48 h induced endogenous glucose production in fetuses at 139‐141 days but not at 133‐135 days of gestation. Maternal fasting also induced increases in the plasma cortisol and noradrenaline levels in all the fetuses studied. Fetal plasma cortisol levels at the end of the fast and the increment in fetal plasma cortisol during maternal fasting were significantly greater in the older groups of fasted animals. When the data from all the fetuses were combined, partial correlation analysis of fetal glucose production and the log plasma concentrations of cortisol and total catecholamines showed that plasma cortisol was the predominant regulator of fetal glucogenesis during late gestation. However, once plasma cortisol levels exceeded 17.5 ng ml−1, plasma catecholamines were a major influence on fetal glucogenesis. The results show that glucogenesis occurs in fetal sheep during late gestation in conditions in which the fetal plasma concentrations of cortisol and catecholamines are elevated. They also suggest that cortisol enhances the capacity for glucogenesis in utero, while catecholamines actually activate glucose production in sheep fetuses close to term.

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  • In late gestation once the sheep fetus has developed the capacity for glucogenesis, the placenta can consume glucose from the fetal circulation if the maternal supply is limited or concentration gradients are manipulated experimentally.

    “However, in late gestation once the sheep fetus has developed the capacity for glucogenesis, the placenta can consume glucose from the fetal circulation if the maternal supply is limited or concentration gradients are manipulated experimentally (190,194,248).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [194]

  • This may reflect the ability of the sheep fetus to supplement its own glucose supply by activating gluconeogenesis, thereby reducing its demand for maternal glucose and sparing glucose for placental functions essential to maintaining pregnancy.

    “This too, may reflect the ability of the sheep fetus to supplement its own glucose supply by activating gluconeogenesis, thereby reducing its demand for maternal glucose and sparing glucose for placental functions essential to maintaining pregnancy (148,194).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [194]

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  1. [33]33. Sperling MA. Relation of glucagon secretion to glucose homeostasis in the perinatal period. Recent Progress in Pediatric Endocrinology. 1977;12:21–32. [[Google Scholar](https://scholar.google.com/scholar_lookup?journal=Recent%20Progress%20in%20Pediatric%20Endocrinology&title=Relation%20of%20glucagon%20secretion%20to%20glucose%20homeostasis%20in%20the%20perinatal%20period&author=MA%20Sperling&volume=12&publication_year=1977&pages=21-32&)]

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Authors
Fowden, A. L., Mundy, L., & the late Silver, M.
Affiliations
University of Cambridge (GB)
ORCID
Fowden, Abigail L.
Venue
The Journal of Physiology
Publisher
Wiley
Published
1998-05
Volume
508
Issue
3
Pages
937-947
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1111/j.1469-7793.1998.937bp.x
PMC
PMC2230917
OpenAlex
W2115513517
Cited by
85
References
39
Citations by year
2026: 3 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 5
FWCI
2.18
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2336 d)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
Keywords
fetal sheep, late pregnancy, maternal fasting, fetal cortisol, catecholamines, endogenous glucose production, fetal development
MeSH terms
Animals, Blood Glucose, Catecholamines, Fasting, Female, Fetus, Glucose, Glucose-6-Phosphatase, Glycogen, Hydrocortisone, Liver, Pregnancy, Sheep

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