The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The role of BK‐type Ca2+‐dependent K+channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells
Open accessAbstract
1. The role of large-conductance Ca2+-dependent K+ channels (BK-channels; also known as maxi-K- or slo-channels) in spike broadening during repetitive firing was studied in CA1 pyramidal cells, using sharp electrode intracellular recordings in rat hippocampal slices, and computer modelling. 2. Trains of action potentials elicited by depolarizing current pulses showed a progressive, frequency-dependent spike broadening, reflecting a reduced rate of repolarization. During a 50 ms long 5 spike train, the spike duration increased by 63.6 +/- 3.4 % from the 1st to the 3rd spike. The amplitude of the fast after-hyperpolarization (fAHP) also rapidly declined during each train. 3. Suppression of BK-channel activity with (a) the selective BK-channel blocker iberiotoxin (IbTX, 60 nM), (b) the non-peptidergic BK-channel blocker paxilline (2-10 microM), or (c) calcium-free medium, broadened the 1st spike to a similar degree ( approximately 60 %). BK-channel suppression also caused a similar change in spike waveform as observed during repetitive firing, and eliminated (occluded) most of the spike broadening during repetitive firing. 4. Computer simulations using a reduced compartmental model with transient BK-channel current and 10 other active ionic currents, produced an activity-dependent spike broadening that was strongly reduced when the BK-channel inactivation mechanism was removed. 5. These results, which are supported by recent voltage-clamp data, strongly suggest that in CA1 pyramidal cells, fast inactivation of a transient BK-channel current (ICT), substantially contributes to frequency-dependent spike broadening during repetitive firing.
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Citations
Cites
Chapter 12 Potassium currents in hippocampal pyramidal cells
Storm, J. F. (1990) · Progress in Brain Research · doi:10.1016/s0079-6123(08)61248-0 · Cited by 743
Self-citationCalcium-dependent current generating the afterhyperpolarization of hippocampal neurons
Lancaster, B., & Adams, P. R. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.55.6.1268 · Cited by 547 · cited 1×
“(2) Although the BK-like Ca¥-dependent K¤ current in hippocampal pyramidal cells was initially described as a sustained current, IC (Lancaster & Adams, 1986), some voltage-clamp and single-channel studies also reported evidence for a fast transient, tetraethylammonium-sensitive Ca¥-dependent K¤…”
Background
Cited by
The action potential in mammalian central neurons
Bean, B. P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2148 · Cited by 1,785
Hu, H., Vervaeke, K., & Storm, J. F. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.029249 · Cited by 417
Self-citationGu, N., Vervaeke, K., Hu, H., & Storm, J. F. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.086835 · Cited by 363
Self-citationSantini, E., Quirk, G. J., & Porter, J. T. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2623-07.2008 · Cited by 275
Ca2+-Activated K+Channels: From Protein Complexes to Function
Berkefeld, H., Fakler, B., & Schulte, U. (2010) · Physiological Reviews · doi:10.1152/physrev.00049.2009 · Cited by 274
Metadata
- Authors
- Shao, L., Halvorsrud, R., Borg‐Graham, L., & Storm, J. F.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1999-11
- Volume
- 521
- Issue
- 1
- Pages
- 135-146
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1991673195
- Cited by
- 380
- References
- 2
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Shao, L., Halvorsrud, R., Borg‐Graham, L., & Storm, J. F. (1999). The role of BK‐type Ca2+‐dependent K+channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells. The Journal of Physiology. https://doi.org/10.1111/j.1469-7793.1999.00135.x
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