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Cited by 29Heart Rate Variability and Autonomic ControlTakotsubo Cardiomyopathy and Associated PhenomenaCardiovascular, Neuropeptides, and Oxidative Stress Research

Reflex effects of independent stimulation of coronary and left ventricular mechanoreceptors in anaesthetised dogs

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Wright, C., Drinkhill, M. J., Hainsworth, R.·2000·The Journal of Physiology
DOI 10.1111/j.1469-7793.2000.00349.xPMC PMC2270136
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Abstract

Previous studies which have indicated that the stimulation of ventricular mechanoreceptors induces significant reflex responses can be criticised because of the likelihood of concomitant stimulation of coronary arterial baroreceptors. We therefore undertook this investigation to examine the coronary and ventricular mechanoreflexes in a preparation in which the pressure stimuli to each region were effectively separated. Dogs were anaesthetised, artificially ventilated and placed on cardiopulmonary bypass. A balloon at the ventricular outflow separated pressure in the left ventricle from that perfusing the coronary arteries. Ventricular pressures were changed by varying inflow and outflow of blood entering and leaving the ventricle through an apical cannula, and coronary pressure by changing pressure in a reservoir connected to a cannula tied in the aortic root. Pressures distending carotid and aortic baroreceptors were controlled. Changes in descending aortic perfusion pressure (flow constant) were used to assess systemic vascular responses. Large changes in carotid sinus and coronary pressures decreased vascular resistance by 35+/-1.9 and 40+/-2.5%, respectively. Intracoronary injections of veratridine (30-60 microg) decreased vascular resistance by 31+/-2.5%. However, large increases in ventricular pressure decreased resistance by only 9+/-2.2%. Significant changes in vascular resistance were obtained with increases in coronary arterial pressure from 60 to 90 mmHg. However, ventricular pressures had to increase to 152/18 mmHg (systolic/end-diastolic) before there was a significant response. These results show that coronary mechanoreceptors are likely to play an important role in cardiovascular control. If ventricular receptors have any function at all, it is as a protective mechanism during gross distension, possibly associated with myocardial ischaemia.

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  • Isolated ventricular distension has only a small effect on systemic perfusion pressure (vascular resistance) until distension is excessive.

    “recent experimental evidence suggests that isolated ventricular distension has only a small effect on systemic perfusion pressure (vascular resistance) until distension is excessive (39).”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [39]

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Research works printed but not linked: 2

  1. Thorén PN. Reflex effects of left ventricular mechanoreceptors with afferent fibers in the vagal nerves. In: Hainsworth R, Kidd C, Linden RJ, editors. Cardiac Receptors. Cambridge, UK: Cambridge University Press; 1979. pp. 259–277. [Google Scholar]
  2. Von Bezold AV, Hirt L. Über die physiolischen Wirkungendes essigsauren Veratrins. In: Von Bezold AV, editor. Untersuchungen aus dem physiologischen Laboratorium in Würzberg. Vol. 1. Leipzig: Engelmann; 1867. pp. 75–156. [Google Scholar]

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Authors
Wright, C., Drinkhill, M. J., & Hainsworth, R.
Affiliations
University of Leeds (GB)
Corresponding author
Drinkhill, M. J.
ORCID
Drinkhill, M. J.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2000-10
Volume
528
Issue
2
Pages
349-358
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1111/j.1469-7793.2000.00349.x
PMC
PMC2270136
OpenAlex
W2093149887
Cited by
29
References
29
Citations by year
2026: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2016: 1 · 2013: 1 · 2012: 1
FWCI
1.98
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
  • Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords
mechanoreflex, ventricular pressure, vascular resistance, baroreceptors, cardiopulmonary bypass, veratridine, myocardial ischemia, cardiovascular regulation
MeSH terms
Anesthesia, Animals, Blood Pressure, Carotid Arteries, Coronary Vessels, Dogs, Female, Heart, Male, Mechanoreceptors, Pressoreceptors, Reflex, Vascular Resistance, Ventricular Function

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