The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation
Open accessAbstract
In this paper we demonstrate in the intact human the possibility of a non-invasive modulation of motor cortex excitability by the application of weak direct current through the scalp. Excitability changes of up to 40 %, revealed by transcranial magnetic stimulation, were accomplished and lasted for several minutes after the end of current stimulation. Excitation could be achieved selectively by anodal stimulation, and inhibition by cathodal stimulation. By varying the current intensity and duration, the strength and duration of the after-effects could be controlled. The effects were probably induced by modification of membrane polarisation. Functional alterations related to post-tetanic potentiation, short-term potentiation and processes similar to postexcitatory central inhibition are the likely candidates for the excitability changes after the end of stimulation. Transcranial electrical stimulation using weak current may thus be a promising tool to modulate cerebral excitability in a non-invasive, painless, reversible, selective and focal way.
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“The principal mechanism of action involves a subtle alteration of a neuron’s resting membrane potential affecting the neuron’s probability of firing [22].”
From Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial (2023) · cites this paper as [22]
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What's wrong with Bonferroni adjustments
Perneger, T. V. (1998) · BMJ · doi:10.1136/bmj.316.7139.1236 · Cited by 5,900
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
Induction of plasticity in the human motor cortex by paired associative stimulation
Stefan, K. (2000) · Brain · doi:10.1093/brain/123.3.572 · Cited by 1,484
Bindman, L. J., Lippold, O. C. J., & Redfearn, J. W. T. (1964) · The Journal of Physiology · doi:10.1113/jphysiol.1964.sp007425 · Cited by 969
Artola, A., Bröcher, S., & Singer, W. (1990) · Nature · doi:10.1038/347069a0 · Cited by 880
INTRACELLULAR ACTIVITIES AND EVOKED POTENTIAL CHANGES DURING POLARIZATION OF MOTOR CORTEX.
Purpura, D., & McMurtry, J. G. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.1.166 · Cited by 875
Polarization of the human motor cortex through the scalp
Priori, A., Berardelli, A., Rona, S., Accornero, N., & Manfredi, M. (1998) · Neuroreport · doi:10.1097/00001756-199807130-00020 · Cited by 568
Influence of transcortical d-c currents on cortical neuronal activity
Creutzfeldt, O. D., Fromm, G. H., & Kapp, H. (1962) · Experimental Neurology · doi:10.1016/0014-4886(62)90056-0 · Cited by 555
Long-term reorganization of human motor cortex driven by short-term sensory stimulation
Hamdy, S., Rothwell, J. C., Aziz, Q., Singh, K. D., & Thompson, D. G. (1998) · Nature Neuroscience · doi:10.1038/264 · Cited by 494
Mechanisms of Deafferentation-Induced Plasticity in Human Motor Cortex
Ziemann, U., Hallett, M., & Cohen, L. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-07000.1998 · Cited by 408
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Huang, Y.-Z., Edwards, M. J., Rounis, E., Bhatia, K. P., & Rothwell, J. C. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.033 · Cited by 4,158
Transcranial direct current stimulation: State of the art 2008
Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., et al. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.004 · Cited by 3,057
“For 4 seconds of tDCS, which elicits no after-effects, a break of 10 seconds between each period of stimulation is sufficient.(13) For tDCS durations that produce short-lasting (namely, for about 10 minutes) after-effects, a 1-hour break between stimulation sessions is sufficient.”
BackgroundResultInfluentialSelf-citationRossini, P., Burke, D. F., Chen, R., Cohen, L., Daskalakis, Z., Iorio, R. D., di Lazzaro, V., Ferreri, F., Fitzgerald, P., George, M., et al. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.02.001 · Cited by 2,729
Self-citationSustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
Nitsche, M. A., & Paulus, W. (2001) · Neurology · doi:10.1212/wnl.57.10.1899 · Cited by 2,617
Self-citationEvidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)
Lefaucheur, J., Antal, A., Ayache, S. S., Benninger, D. H., Brunelin, J., Cogiamanian, F. M., Cotelli, M., Ridder, D. D., Ferrucci, R., Langguth, B., et al. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2016.10.087 · Cited by 1,968
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Metadata
- Authors
- Nitsche, M. A., & Paulus, W.
- Affiliations
- University of Göttingen (DE)
- Corresponding author
- Nitsche, M. A.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2000-09
- Volume
- 527
- Issue
- 3
- Pages
- 633-639
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC2270099
- OpenAlex
- W2097273459
- Cited by
- 5,656
- References
- 29
- Citations by year
- 2026: 264 · 2025: 352 · 2024: 344 · 2023: 329 · 2022: 354 · 2021: 455 · 2020: 449 · 2019: 426 · 2018: 361 · 2017: 357 · 2016: 380 · 2015: 315 · 2014: 263 · 2013: 274 · 2012: 195
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- transcranial direct current stimulation, motor cortex excitability, non-invasive brain stimulation, anodal stimulation, cathodal stimulation, aftereffects, post-tetanic potentiation, short-term potentiation, membrane polarization, transcranial magnetic stimulation
- MeSH terms
- Adult, Electric Stimulation, Electromagnetic Fields, Female, Humans, Male, Motor Cortex, Evoked Potentials, Motor
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