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Cited by 50Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionIon channel regulation and function

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Two distinct oscillatory states determined by the NMDA receptor in rat inferior olive

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Placantonakis, Dimitris G., Welsh, John P.·2001·The Journal of Physiology
DOI 10.1111/j.1469-7793.2001.t01-1-00123.xPMC PMC2278697
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Abstract

1. The effects of N-methyl-D-aspartate (NMDA) receptor activation and blockade on subthreshold membrane potential oscillations of inferior olivary neurones were studied in brainstem slices from 12- to 21-day-old rats. 2. Dizocilpine (MK-801), a non-competitive NMDA antagonist, at 1-45 microM abolished spontaneous subthreshold oscillations, without affecting membrane potential, input resistance, or the low-threshold calcium current, I(T). Ketamine (100 microM), a non-competitive NMDA antagonist, and L-689,560 (20 microM), an antagonist at the glycine site of the NMDA receptor, also abolished the oscillations, while the competitive non-NMDA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 20-50 microM) had no effect. 3. NMDA (100 microM) induced 4.1 Hz subthreshold oscillations and reversibly depolarized olivary neurones by 13.7 mV. In contrast, 10 microM alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and 20 microM kainic acid depolarized the membrane equivalently but did not induce oscillations. 4. Both NMDA-induced and spontaneous subthreshold oscillations were unaffected by 1 microM tetrodotoxin and were prevented by substituting extracellular calcium with cobalt. 5. Removing magnesium from the perfusate did not affect spontaneous subthreshold oscillations but did prevent NMDA-induced oscillations. 6. NMDA-induced oscillations were resistant to 50 microM mibefradil, an I(T) blocker, in contrast to spontaneous oscillations. Both oscillations were inhibited by 20 microM nifedipine, an L-type calcium channel antagonist, and 200 nM omega-agatoxin IVA, a P-type calcium channel blocker. Bay K 8644 (10 microM), an L-type Ca(2+) agonist, significantly enhanced the amplitude of both spontaneous and NMDA-induced oscillations. 7. The data indicate that NMDA receptor activation induces olivary neurones to manifest high amplitude membrane potential oscillations in part mediated by L- and P- but not T-type calcium currents. Moreover, the data demonstrate that NMDA receptor currents are necessary for generation of spontaneous subthreshold oscillations in the inferior olive.

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Crossref · 10.1111/j.1469-7793.2001.t01-1-00123.x

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Citations

Cites

Research works printed but not linked: 4

  1. Lodge D., 1994, The NMDA Receptor, 105
  2. Manfridi A., 1993, FTX selectively blocks P‐type calcium current in hippocampal and olivary neurons, Society for Neuroscience Abstracts, 19, 1754
  3. Placantonakis D. G., 1999, NMDA receptor involvement in subthreshold oscillations of the inferior olive, Society for Neuroscience Abstracts, 25, 1560
  4. Welsh J. P., 2000, Is zebrin II neuroprotective, Society for Neuroscience Abstracts, 26, 1988

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Metadata

Authors
Placantonakis, D. G., & Welsh, J. P.
Affiliations
Oregon Health & Science University (US)
ORCID
Placantonakis, Dimitris G.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2001-07
Volume
534
Issue
1
Pages
123-140
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1111/j.1469-7793.2001.t01-1-00123.x
PMC
PMC2278697
OpenAlex
W2117510935
Cited by
49
References
52
Citations by year
2025: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 6 · 2013: 2 · 2012: 8
FWCI
0.74
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service
  • National Institute of Neurological Disorders and Stroke (NS31224, R56NS031224, R01NS031224)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
inferior olive, NMDA receptor, L-type calcium channels, P-type calcium channels, T-type calcium current, glycine site antagonists, low-threshold calcium current, magnesium dependence, synaptic plasticity, cerebellar nuclei, brainstem slices, ketamine, MK-801
MeSH terms
Animals, Calcium, Differential Threshold, Electric Conductivity, Electrophysiology, Magnesium, Membrane Potentials, Neurons, Olivary Nucleus, Oscillometry, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Rats, Sprague-Dawley, Excitatory Amino Acid Agonists, Calcium Channels, L-Type, Calcium Channels, P-Type, Rats, In Vitro Techniques

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