The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of supply and demand for maternal nutrients in mammals by imprinted genes
Open accessAbstract
The placenta has evolved in eutherian mammals primarily to provide nutrients for the developing fetus. The genetic control of the regulation of supply and demand for maternal nutrients is not understood. In this review we argue that imprinted genes have central roles in controlling both the fetal demand for, and the placental supply of, maternal nutrients. Recent studies on Igf2 (insulin-like growth factor 2) knockout mouse models provide experimental support for this hypothesis. These show effects on placental transport capacity consistent with a role of IGF-II in modulating both the placental supply and fetal demand for nutrients. Imprinting of genes with such functions may have coevolved with the placenta and new evidence suggests that transporter proteins, as well as the regulators themselves, may also be imprinted. These data and hypotheses are important, as deregulation of supply and demand affects fetal growth and has long term consequences for health in mammals both in the neonatal period and, as a result of fetal programming, in adulthood.
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Citations
Cites
Genomic imprinting in mammalian development: a parental tug-of-war
Moore, T. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90230-n · Cited by 1,281
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Self-citation
Cited by
Jansson, T., & Powell, T. L. (2007) · Clinical Science · doi:10.1042/cs20060339 · Cited by 542
Gene expression patterns in human placenta
Sood, R., Zehnder, J. L., Druzin, M. L., & Brown, P. O. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508035103 · Cited by 454
The macrosomic fetus: a challenge in current obstetrics
HENRIKSEN, T. (2008) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1080/00016340801899289 · Cited by 454
Nelissen, E. C. M., van Montfoort, A. P. A., Dumoulin, J. C. M., & Evers, J. L. H. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq052 · Cited by 384
What is fetal programming?: a lifetime health is under the control of in utero health
Kwon, E. J., & Kim, Y. J. (2017) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2017.60.6.506 · Cited by 375
Metadata
- Authors
- Reik, W., Constancia, M., Fowden, A., Anderson, N., Dean, W., Ferguson-Smith, A., Tycko, B., & Sibley, C.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2003-02
- Volume
- 547
- Issue
- 1
- Pages
- 35-44
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2165700698
- Cited by
- 412
- References
- 2
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- doi.wiley.com/10.1002/tdm_license_1 (tdm, 4603 d)
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- Reik, W., Constancia, M., Fowden, A., Anderson, N., Dean, W., Ferguson-Smith, A., Tycko, B., & Sibley, C. (2003). Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. The Journal of Physiology. https://doi.org/10.1111/j.1469-7793.2003.00035.x
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