Cited by 1,281Genetic Syndromes and ImprintingChromosomal and Genetic VariationsBirth, Development, and Health

Genomic imprinting in mammalian development: a parental tug-of-war

Moore, T·1991·Trends in Genetics

Abstract

Genomic imprinting in mammals is increasingly being implicated in developmental and pathological processes, but without a clear understanding of its function in normal development. We believe that imprinting has evolved in mammals because of the conflicting interests of maternal and paternal genes in relation to the transfer of nutrients from the mother to her offspring. We present an hypothesis that accounts for many of the observed effects of imprinting in mammals and relates them to similar observations in plants. This hypothesis has implications for studies of X-chromosome inactivation and a range of human diseases.

Integrity signals

Registry

Crossref · 10.1016/0168-9525(91)90230-n

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • This leads to differential selection pressures on maternally and paternally inherited alleles in the conceptus with respect to resource allocation and is manifested as genomic imprinting, a mechanism for monoallelically regulating gene dosage in a parent-of-origin fashion.

    “This leads to differential selection pressures on maternally and paternally inherited alleles in the conceptus with respect to resource allocation and is manifested as genomic imprinting, a mechanism for monoallelically regulating gene dosage in a parent-of-origin fashion (305, 391).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [391]

  • In evolutionary terms the role of imprinting has been explained as a means by which the male optimises the spread of his genome through the population.

    “In evolutionary terms the role of imprinting has been explained as a means by which the male optimises the spread of his genome through the population (391).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [391]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Moore, T.
Affiliations
St George's, University of London (GB)
Corresponding author
Moore, T
Venue
Trends in Genetics
Publisher
Elsevier BV
Published
1991-02
Volume
7
Issue
2
Pages
45-49
ISSN
0168-9525 (ISSN-L)
OpenAlex
W1985467296
Cited by
1,281
References
29
Citations by year
2026: 16 · 2025: 18 · 2024: 31 · 2023: 32 · 2022: 41 · 2021: 36 · 2020: 27 · 2019: 46 · 2018: 40 · 2017: 33 · 2016: 34 · 2015: 53 · 2014: 61 · 2013: 47 · 2012: 57
FWCI
13.81
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
genomic imprinting, mammalian development, nutrient transfer, X chromosome inactivation, human disease
MeSH terms
Animals, Biological Evolution, Embryonic and Fetal Development, Humans, X Chromosome, Gene Expression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review