Genomic imprinting in mammalian development: a parental tug-of-war
Abstract
Genomic imprinting in mammals is increasingly being implicated in developmental and pathological processes, but without a clear understanding of its function in normal development. We believe that imprinting has evolved in mammals because of the conflicting interests of maternal and paternal genes in relation to the transfer of nutrients from the mother to her offspring. We present an hypothesis that accounts for many of the observed effects of imprinting in mammals and relates them to similar observations in plants. This hypothesis has implications for studies of X-chromosome inactivation and a range of human diseases.
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This leads to differential selection pressures on maternally and paternally inherited alleles in the conceptus with respect to resource allocation and is manifested as genomic imprinting, a mechanism for monoallelically regulating gene dosage in a parent-of-origin fashion.
“This leads to differential selection pressures on maternally and paternally inherited alleles in the conceptus with respect to resource allocation and is manifested as genomic imprinting, a mechanism for monoallelically regulating gene dosage in a parent-of-origin fashion (305, 391).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [391]
In evolutionary terms the role of imprinting has been explained as a means by which the male optimises the spread of his genome through the population.
“In evolutionary terms the role of imprinting has been explained as a means by which the male optimises the spread of his genome through the population (391).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [391]
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- Authors
- Moore, T.
- Affiliations
- St George's, University of London (GB)
- Corresponding author
- Moore, T
- ORCID
- Moore, T
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 1991-02
- Volume
- 7
- Issue
- 2
- Pages
- 45-49
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W1985467296
- Cited by
- 1,281
- References
- 29
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 31 · 2023: 32 · 2022: 41 · 2021: 36 · 2020: 27 · 2019: 46 · 2018: 40 · 2017: 33 · 2016: 34 · 2015: 53 · 2014: 61 · 2013: 47 · 2012: 57
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- genomic imprinting, mammalian development, nutrient transfer, X chromosome inactivation, human disease
- MeSH terms
- Animals, Biological Evolution, Embryonic and Fetal Development, Humans, X Chromosome, Gene Expression
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