Emotional and behavioural aspects of Rett syndrome.
Abstract
A survey of 107 families of children with Rett syndrome was conducted to further define the behavioural phenotype. There was a high prevalence of behavioural and emotional problems, including episodes of anxiety (76 per cent), low mood (70 per cent) and self-injurious behaviour (49 per cent). Although there was no significant difference across the age-ranges studied, there was a tendency towards a reduction in these problems with increasing age, suggesting that the behavioural phenotype in Rett syndrome varies with age. Epilepsy occurred in over half the children, but there was no clear association with behavioural and emotional problems. A number of families had established strategies for coping with their child's anxiety and mood changes.
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Individuals with these disorders report an increase in anxiety.
“Although it is not clear whether abnormal developmental expression of NCoR directly impacts these disorders, it is interesting to note that individuals with these disorders report an increase in anxiety (46 -48).”
From The Nuclear Receptor Corepressor Has Organizational Effects within the Developing Amygdala on Juvenile Social Play and Anxiety-Like Behavior (2010) · cites this paper as [46]
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Kalueff, A. V., Wheaton, M., & Murphy, D. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.023 · Cited by 285 · see citing works
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- Authors
- Sansom, D., Krishnan, V. H. R., Corbett, J., & Kerr, A.
- Affiliations
- University of Birmingham (GB)
- University of Glasgow (GB)
- ORCID
- Kerr, Alison
- Venue
- Developmental Medicine & Child Neurology
- Publisher
- Wiley
- Published
- 1993-04
- Volume
- 35
- Issue
- 4
- Pages
- 340-345
- ISSN
- 0012-1622 (ISSN-L)
- 1469-8749
- OpenAlex
- W2075213922
- Cited by
- 84
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 6 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 6
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Medicine & Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- Rett syndrome, behavioral phenotypes, emotional problems, anxiety, depressive mood, self-harm, epilepsy, age-related changes, coping strategies, families of children with disabilities
- MeSH terms
- Activities of Daily Living, Adaptation, Psychological, Adolescent, Affective Symptoms, Child, Child Behavior Disorders, Child, Preschool, Epilepsy, Tonic-Clonic, Family, Female, Humans, Parents, Surveys and Questionnaires, Cohort Studies, Rett Syndrome, Prevalence, Self-Injurious Behavior
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