What's wrong with my mouse model?
Abstract
Stress plays a key role in pathogenesis of anxiety and depression. Animal models of these disorders are widely used in behavioral neuroscience to explore stress-evoked brain abnormalities, screen anxiolytic/antidepressant drugs and establish behavioral phenotypes of gene-targeted or transgenic animals. Here we discuss the current situation with these experimental models, and critically evaluate the state of the art in this field. Noting a deficit of fresh ideas and especially new paradigms for animal anxiety and depression models, we review existing challenges and outline important directions for further research in this field.
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Social phenotypes manifested outside of naturally relevant social contexts might be misinterpreted or indiscernible.
“Thus, social phenotypes manifested outside of naturally relevant social contexts might be misinterpreted or indiscernible 16 .”
From Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics (2016) · cites this paper as [16]
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Self-citation
- Authors
- Kalueff, A. V., Wheaton, M., & Murphy, D. L.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Kalueff, A.V.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 179
- Issue
- 1
- Pages
- 1-18
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2144594810
- Cited by
- 285
- References
- 370
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 10 · 2017: 11 · 2016: 13 · 2015: 18 · 2014: 23 · 2013: 20 · 2012: 24
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- animal models of anxiety, animal models of depression, stress, behavioral phenotypes, transgenic animals
- MeSH terms
- Animals, Anxiety, Mental Disorders, Depression, Depressive Disorder, Disease Models, Animal, Mice, Transgenic, Stress, Psychological, Behavioral Research, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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