Cited by 285Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

What's wrong with my mouse model?

Kalueff, A.V., Wheaton, M., Murphy, D.L.·2007·Behavioural Brain Research

Abstract

Stress plays a key role in pathogenesis of anxiety and depression. Animal models of these disorders are widely used in behavioral neuroscience to explore stress-evoked brain abnormalities, screen anxiolytic/antidepressant drugs and establish behavioral phenotypes of gene-targeted or transgenic animals. Here we discuss the current situation with these experimental models, and critically evaluate the state of the art in this field. Noting a deficit of fresh ideas and especially new paradigms for animal anxiety and depression models, we review existing challenges and outline important directions for further research in this field.

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Crossref · 10.1016/j.bbr.2007.01.023

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370 of 370 references verified0 citation errors · 0 not checkable

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  • Social phenotypes manifested outside of naturally relevant social contexts might be misinterpreted or indiscernible.

    “Thus, social phenotypes manifested outside of naturally relevant social contexts might be misinterpreted or indiscernible 16 .”

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Authors
Kalueff, A. V., Wheaton, M., & Murphy, D. L.
Affiliations
National Institute of Mental Health (US)
Corresponding author
Kalueff, A.V.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2007-04
Volume
179
Issue
1
Pages
1-18
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2144594810
Cited by
285
References
370
Citations by year
2026: 7 · 2025: 10 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 10 · 2017: 11 · 2016: 13 · 2015: 18 · 2014: 23 · 2013: 20 · 2012: 24
FWCI
1.70
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
animal models of anxiety, animal models of depression, stress, behavioral phenotypes, transgenic animals
MeSH terms
Animals, Anxiety, Mental Disorders, Depression, Depressive Disorder, Disease Models, Animal, Mice, Transgenic, Stress, Psychological, Behavioral Research, Mice

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