MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome
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Rett syndrome (RTT) is an X-linked neurodevelopmental disorder that results from loss of function mutations in the methyl-CpG binding protein 2 (MECP2) gene. Using viral-mediated basolateral amygdala (BLA)-specific deletion of Mecp2 in mice, we show that intact Mecp2 function is required for normal anxiety behavior as well as some types of learning and memory. To examine whether these behavioral deficits are the result of impaired transcriptional repression, because Mecp2 is believed to act as a transcriptional repressor in complex with histone deacetylases (HDACs), we infused a HDAC inhibitor chronically into the BLA of wild-type mice. We found that HDAC inhibition produces behavioral deficits similar to those observed after the deletion of Mecp2 in the BLA. These results suggest a key role for Mecp2 as a transcriptional repressor in the BLA in mediating behavioral features of RTT.
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MeCP2 may be required to recruit HDACs to maintain lower levels of acetylation necessary for gene repression.
“This was accompanied by an increase in H3 acetylation, indicating that MeCP2 may be required to recruit HDACs to maintain lower levels of acetylation necessary for gene repression (Adachi et al., 2009).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Adachi et al., 2009
The Results (page not provided) report that MeCP2 loss in the basolateral amygdala increased H3 acetylation, and that HDAC inhibition increased histone acetylation. The Discussion (page not provided) interprets the findings as consistent with impaired transcriptional repression. These passages support the proposed link, but do not establish the specific step of MeCP2 recruiting HDACs. (LLM, conf=0.82)
Experimental — accuracy not yet measuredViral deletion of MeCP2 in the BLA of mice was accompanied by an increase in H3 acetylation.
“This was accompanied by an increase in H3 acetylation, indicating that MeCP2 may be required to recruit HDACs to maintain lower levels of acetylation necessary for gene repression (Adachi et al., 2009).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Adachi et al., 2009
Viral deletion of MeCP2 in the BLA of mice resulted in an increase in anxiety-like behaviors.
“In a study published a few years later, viral deletion of MeCP2 in the BLA of mice resulted in an increase in anxiety-like behaviors.”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Adachi et al., 2009
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- Authors
- Adachi, M., Autry, A. E., Covington, H. E., & Monteggia, L. M.
- Affiliations
- The University of Texas at Dallas (US)
- The University of Texas Southwestern Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-04-01
- Volume
- 29
- Issue
- 13
- Pages
- 4218-4227
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3005250
- OpenAlex
- W1993341628
- Cited by
- 135
- References
- 51
- Citations by year
- 2026: 6 · 2025: 1 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 9 · 2015: 8 · 2014: 16 · 2013: 10 · 2012: 22
- FWCI
- 9.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- International Rett Syndrome Foundation
- National Institute of Mental Health (R01MH081060, R21MH077944, MH077944)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- Rett syndrome, MeCP2, basolateral amygdala, anxiety, transcriptional repression, histone deacetylase, histone deacetylase inhibition, learning and memory, viral gene deletion, mouse model
- MeSH terms
- Vorinostat, Amygdala, Animals, Anxiety, Conditioning, Psychological, Disease Models, Animal, Enzyme Inhibitors, Fear, Histone Deacetylases, Hydroxamic Acids, Interpersonal Relations, Male, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Mutation, Neurons, Time Factors, Transcription, Genetic, Rett Syndrome, Pain Threshold, Maze Learning, Recombinases, Green Fluorescent Proteins, Mice, Methyl-CpG-Binding Protein 2
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