Effects of very low birthweight on brain structure in adulthood
Open accessAbstract
Very‐low‐birth weight (VLBW) individuals are at high risk of brain injury in the perinatal period. We wished to determine how such early brain lesions affect brain structure in adulthood. Thirty‐two VLBW adults (20 female, 12 male) and 18 term, normal birthweight sibling control individuals (nine female, nine male) underwent structural MRI at a mean age of 23 years 4 months (range 17 to 33 years; SD 3.4). Images were analyzed using an automated tissue segmentation algorithm in order to estimate whole brain tissue class volumes in native space. Images were then warped to a template image in standard space. There was no significant between‐group difference in whole brain, grey matter, white matter, or total cerebral spinal fluid (CSF) volumes. However, lateral ventricular volume was significantly increased by 41% in those with VLBW. The ratio of grey to white matter was also significantly increased (by 10%) in those with VLBW. Group comparison maps showed widespread changes in the distribution of grey and white matter, and relative excess of ventricular CSF, in the brains of VLBW individuals. Increased ventricular volume predicted decreased grey matter in subcortical nuclei and limbic cortical structures, and decreased periventricular white matter. We conclude that these diffuse abnormalities of grey and white matter are a consequence of the interaction of perinatal brain injury and ongoing neurodevelopmental processes.
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In preterm birth, changes in white and gray matter including reductions in cortical surface area and cortical thickness of the PFC are described.
“In preterm birth, changes in white and gray matter including reductions in cortical surface area and cortical thickness of the PFC are described [361–364].”
From Development of prefrontal cortex (2022) · cites this paper as [361]
The Discussion reports altered grey- and white-matter distribution in adults of very low birthweight, supporting the broad claim of structural changes. The Results describe regional tissue-density differences, not reductions in prefrontal cortical surface area or thickness; the Discussion instead describes another study's prefrontal regions as non-significantly larger. (LLM, conf=0.88)
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Self-citation
- Authors
- Allin, M., Henderson, M., Suckling, J., Nosarti, C., Rushe, T., Fearon, P., Stewart, A. L., Bullmore, E., Rifkin, L., & Murray, R.
- Affiliations
- King's College London (GB)
- University of Ulster (GB)
- University College London (GB)
- Corresponding author
- Allin, Matthew
- Venue
- Developmental Medicine & Child Neurology
- Publisher
- Wiley
- Published
- 2004-01
- Volume
- 46
- Issue
- 1
- Pages
- 46-53
- ISSN
- 0012-1622 (ISSN-L)
- 1469-8749
- OpenAlex
- W4239731113
- Cited by
- 102
- References
- 63
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 6 · 2012: 7
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Medicine & Child Neurology (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- very low birth weight, perinatal brain injury, lateral ventricular enlargement, grey matter, white matter, cerebrospinal fluid, brain development, subcortical nuclei, limbic cortex, periventricular white matter, brain tissue segmentation
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