Epilepsy in hemiplegic cerebral palsy due to perinatal arterial ischaemic stroke
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Aim The aim of this study was to describe the frequency, risk factors, manifestations, and outcome of epilepsy in children with hemiplegic cerebral palsy (CP) due to perinatal arterial ischaemic stroke (AIS). Method The study group comprised 63 participants (41 males, 22 females) from a population‐based CP register whose brain imaging showed perinatal AIS. Information collected included occurrence of neonatal seizures, family history of epilepsy, motor function and epilepsy onset, treatment, and outcome. Electroclinical findings were classified according to seizure semiology, seizure type, and epilepsy syndrome. Results Mean age of participants at the time of study was 10 years 6 months (SD 4y 7mo, range 4–20y). Gross Motor Function Classification System levels I and II were reported in 96% of participants, and Manual Ability Classification System levels I and II were reported in 79% of children. Thirty‐four children (54%) developed epilepsy. Term delivery and more severe motor impairment were associated with epilepsy, but neonatal seizures and family history of epilepsy were not. Initial seizures were epileptic spasms, focal seizures, or myoclonic seizures. Focal seizure semiology suggested Rolandic or occipital seizure origin in the majority of children. Focal epileptic discharges in children with focal seizures had features of idiopathic partial epilepsy. Only 15% of children had active epilepsy 10 years after onset. Interpretation Despite a high incidence of epilepsy in children with hemiplegic CP due to AIS, the prognosis for seizure remission is good. Many children have clinical features, electroencephalography findings, and remission typical of idiopathic partial epilepsy.
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The development of epilepsy after brain injury in the neonatal period is reported in various studies, but it normally responds well to drug therapy.
“The development of epilepsy after brain injury in the neonatal period is reported in various studies, but normally responds well to drug therapy.90”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [90]
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Clinical Prognostic Messages from a Systematic Review on Cerebral Palsy
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- Authors
- WANIGASINGHE, J., REID, S. M., MACKAY, M. T., REDDIHOUGH, D. S., HARVEY, A. S., & FREEMAN, J. L.
- Affiliations
- University of Colombo (LK)
- Murdoch Children's Research Institute (AU)
- Royal Children's Hospital (AU)
- Corresponding author
- FREEMAN, JEREMY L
- ORCID
- Venue
- Developmental Medicine & Child Neurology
- Publisher
- Wiley
- Published
- 2010-05-24
- Volume
- 52
- Issue
- 11
- Pages
- 1021-1027
- ISSN
- 0012-1622 (ISSN-L)
- 1469-8749
- OpenAlex
- W1603127813
- Cited by
- 69
- References
- 33
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Medicine & Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Cerebral Palsy and Movement Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- epilepsy, spastic hemiplegia, neonatal seizures, family history of epilepsy, seizure semiology, focal seizures, epileptic spasms, myoclonic seizures, idiopathic partial epilepsy, seizure remission, prognosis, motor impairment, children
- MeSH terms
- Adolescent, Brain Ischemia, Cerebral Palsy, Child, Child, Preschool, Diagnostic Imaging, Electroencephalography, Epilepsy, Female, Follow-Up Studies, Humans, Functional Laterality, Male, Quality of Life, Risk Factors, Stroke, Kaplan-Meier Estimate, Young Adult
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