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Cited by 15Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesGastrointestinal motility and disorders

No association between early gastrointestinal problems and autistic-like traits in the general population: Gastrointestinal Symptoms and Autistic-like Traits

WHITEHOUSE, ANDREW J O, MAYBERY, MURRAY, WRAY, JOHN A, HICKEY, MARTHA·2011·Developmental Medicine & Child Neurology
DOI 10.1111/j.1469-8749.2011.03915.x
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Abstract

AIM: The aim of this study was to determine whether gastrointestinal problems in early childhood relate to autistic-like traits in a general population sample. METHOD: The parents of 804 children (442 females; 362 males) reported at 1-, 2-, 3-, and 5-year follow-ups whether their child had been taken to a hospital, general practitioner, or health clinic for any of five gastrointestinal symptoms: (1) constipation; (2) diarrhoea; (3) abdominal bloating, discomfort, or irritability; (4) gastro-oesophageal reflux or vomiting; and (5) feeding issues or food selectivity. Parents also reported whether their child had received the measles, mumps, and rubella vaccination. Autistic-like traits were measured when the children had reached early adulthood (mean age 19 y 7 mo; SD 0.63 y) using a self-report questionnaire, the Autism Spectrum Quotient (AQ). RESULTS: There was no statistically significant difference in AQ scores between those who had (n=133) and those who had not (n=671) experienced early gastrointestinal symptoms. χ(2) analyses revealed that the children with early gastrointestinal problems were no more likely to be represented in the upper quintile of scores on any of the AQ scales. The measles, mumps, and rubella vaccination was unrelated to gastrointestinal symptoms or AQ scores. INTERPRETATION: Parent-reported gastrointestinal problems in early childhood are unrelated to self-reported autistic-like traits in the general population.

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Crossref · 10.1111/j.1469-8749.2011.03915.x

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  • The presence of GI disorders together with food selectivity could constitute a specific clinical phenotype characterized by frequent problematic behaviors such as anxiety, self-aggression, and sleep problems resulting from both conditions.

    “The presence of GI disorders together with food selectivity could constitute a specific clinical phenotype [31,127,135], characterized by frequent problematic behaviors, such as anxiety, self-aggression, sleep problems, resulting from both conditions [136].”

    From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [135]

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Authors
WHITEHOUSE, A. J. O., MAYBERY, M., WRAY, J. A., & HICKEY, M.
Affiliations
  • The Kids Research Institute Australia (AU)
  • The University of Western Australia (AU)
  • Princess Margaret Hospital for Children (AU)
  • The University of Melbourne (AU)
Corresponding author
WHITEHOUSE, ANDREW J O
ORCID
Venue
Developmental Medicine & Child Neurology
Publisher
Wiley
Published
2011-03-21
Volume
53
Issue
5
Pages
457-462
ISSN
0012-1622 (ISSN-L)
DOI
10.1111/j.1469-8749.2011.03915.x
OpenAlex
W1484260089
Cited by
15
References
22
Citations by year
2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2015: 1 · 2013: 4 · 2012: 2
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1625 d)
Locations
  • Developmental Medicine & Child Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gastrointestinal symptoms, autistic traits, autism spectrum disorder, early childhood, constipation, diarrhea, bloating, gastroesophageal reflux, vomiting, feeding difficulties, picky eating, measles-mumps-rubella vaccination, Autism Spectrum Quotient, general population
MeSH terms
Age Factors, Autistic Disorder, Child, Preschool, Female, Follow-Up Studies, Gastrointestinal Diseases, Humans, Infant, Male, Pregnancy, Surveys and Questionnaires, Retrospective Studies, Vaccination, Young Adult

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