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Cited by 52Pregnancy and preeclampsia studiesNeurological Complications and SyndromesPregnancy-related medical research

Transcapillary fluid balance in pre‐eclampsia

ØIAN, PÅL, MALTAU, JAN MARTIN, NODDELAND, HARALD, FADNES, HANS OLAV·1986·BJOG: An International Journal of Obstetrics & Gynaecology
DOI 10.1111/j.1471-0528.1986.tb07899.x
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Abstract

Summary. The fluid transport between the plasma and interstitial fluid compartment is governed by the Starling forces, i.e. the capillary pressure (P c), interstitial fluid hydrostatic pressure (P i) and colloid osmotic pressure in plasma (COP p) and interstitial fluid (COP i). Interstitial fluid was collected from subcutaneous tissue on the thorax and ankle by implanted wicks and Pi was measured using the ‘wick‐in‐needle’ technique. In pre‐eclampsia, COP p, is reduced due to hypoproteinaemia and this predisposes towards loss of fluid from the vascular compartment. An important oedema‐preventing mechanism is reduction of COP i, which serves as a homeostatic buffer against increased capillary filtra‐tion. This mechanism works in moderate, but not in severe preeclampsia. A higher COP i was found both at the thorax (8·3 vs 7·0 mmHg) and ankle (5·9 vs 3·9 mmHg) in the group with severe pre‐eclampsia compared with the group moderate pre‐eclampsia, in spite of a significant reduction in COP p (15·5 vs 19·9 mmHg). These findings suggest that an increased microvascular permeability of plasma proteins to subcutaneous tissue contributes to COP p reduction in severe pre‐eclampsia.

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Crossref · 10.1111/j.1471-0528.1986.tb07899.x

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  • Other sites, including muscle and adipose tissue in collaboration with the liver and possibly the kidney, release solutes into the vascular compartment from where they enter the interstitium at increased rates, facilitated by increased capillary permeability.

    “Other sites (muscle and adipose tissue in collaboration with the liver and, possibly, the kidney12) release these solutes into the vascular compartment from where they enter the extravascular extracellular compartment (interstitium) at increased rates, also facilitated by the increased capillary permeability.4, 13, 14, 15, 16, 17”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [13]

  • Inflammation increases escape of serum albumin from plasma.

    “Inflammation increases capillary permeability and escape of serum albumin, leading to expansion of interstitial space and increasing the distribution volume of albumin.”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [13]

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Authors
ØIAN, P., MALTAU, J. M., NODDELAND, H., & FADNES, H. O.
Affiliations
UiT The Arctic University of Norway (NO)
Corresponding author
ØIAN, PÅL
ORCID
ØIAN, PÅL
Venue
BJOG: An International Journal of Obstetrics & Gynaecology
Publisher
Wiley
Published
1986-03
Volume
93
Issue
3
Pages
235-239
ISSN
  • 0306-5456 (ISSN-L)
  • 1470-0328
  • 1471-0528
DOI
10.1111/j.1471-0528.1986.tb07899.x
OpenAlex
W2028258813
Cited by
52
References
18
Citations by year
2025: 1 · 2021: 2 · 2018: 2 · 2017: 1 · 2014: 1 · 2012: 1
FWCI
6.94
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7115 d)
Locations
  • BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
Keywords
preeclampsia, Starling forces, colloid osmotic pressure, interstitial fluid, capillary pressure, hypoproteinemia, microvascular permeability, edema, subcutaneous tissue, severe preeclampsia
MeSH terms
Blood, Capillaries, Extracellular Space, Female, Humans, Hydrostatic Pressure, Osmotic Pressure, Pre-Eclampsia, Pregnancy, Water-Electrolyte Balance

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