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Cited by 128Pregnancy and preeclampsia studiesNeurological Complications and SyndromesPregnancy-related medical research

Preeclampsia: Pathophysiology, Diagnosis, and Management

Lindheimer, M D, Katz, A I·1989·Annual Review of Medicine
DOI 10.1146/annurev.me.40.020189.001313
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Abstract

Preeclampsia, a major cause of fetal and maternal morbidity and mortality, may be difficult to distinguish clinically from other hypertensive disorders of pregnancy. Signs helpful in its diagnosis include presentation during late gestation in a nullipara with edema and proteinuria, and one or more of the following: hemoconcentration, hypoalbuminemia, liver function and/or coagulation abnormalities, and increased urate levels. Measures that may prove useful in differentiating preeclampsia from less dangerous forms of hypertension are decreased antithrombin III levels, increments in serum iron and carboxyhemoglobin, and decreases in urinary calcium. Major pathophysiological features of preeclampsia are decreased cardiac output, pulmonary capillary wedge pressure, and plasma volume; and marked increases in peripheral vascular resistance, as well as exaggerated pressor responses to endogenous angiotensin II and catecholamines. Renal hemodynamics decrease, in part as a result of a characteristic morphological lesion in glomeruli ("endotheliosis"), and there may be increased vascular permeability leading to albumin loss from the intravascular space. When gestation is advanced, termination is the treatment of choice; when temporization is required, several antihypertensive medications whose safety and efficacy have been tested in pregnant women are available. Magnesium sulfate remains the drug of choice for impending convulsions (the eclamptic phase of the disease). Finally, the etiology of preeclampsia remains unknown, but a popular theory suggests that alterations in prostaglandin metabolism may be responsible for the hypertension and coagulopathy in this disorder. In this respect, prophylactic treatment with low doses of aspirin, which decrease platelet thromboxane production but spare endothelial prostacyclin release, may decrease the incidence of preeclampsia in "high-risk" populations.

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  • A similar pattern is observed for VEGF, stimulating angiogenesis and promoting capillary permeability, leading to expansion of the interstitium.

    “A similar pattern is observed for VEGF, stimulating angiogenesis and promoting capillary permeability,29 leading to expansion of the interstitium.30, 31”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [31]

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Authors
Lindheimer, M. D., & Katz, A. I.
Affiliations
University of Chicago (US)
Venue
Annual Review of Medicine
Publisher
Annual Reviews
Published
1989-02
Volume
40
Issue
1
Pages
233-250
ISSN
  • 0066-4219 (ISSN-L)
  • 1545-326X
DOI
10.1146/annurev.me.40.020189.001313
OpenAlex
W2115403364
Cited by
128
References
47
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 1 · 2016: 11 · 2015: 2 · 2014: 7 · 2013: 6 · 2012: 4
FWCI
12.92
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-24498)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
Keywords
preeclampsia, hypertensive disorders of pregnancy, pathophysiology, proteinuria, endotheliosis, antithrombin III, magnesium sulfate, eclampsia, antihypertensive drugs in pregnancy, aspirin prophylaxis, prostaglandin metabolism, thrombocytopenia, systemic vascular resistance, abortion
MeSH terms
Antihypertensive Agents, Diagnosis, Differential, Eclampsia, Female, Hemodynamics, Humans, Magnesium Sulfate, Pre-Eclampsia, Pregnancy, Dinoprostone

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