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Cited by 35Iron Metabolism and DisordersErythropoietin and Anemia TreatmentHemoglobinopathies and Related Disorders

Effect of postpartum iron supplementation on red cell and iron parameters in non-anaemic iron-deficient women: a randomised placebo-controlled study

Krafft, A., Perewusnyk, G., Hänseler, E., Quack, K., Huch, R., Breymann, C.·2005·BJOG: An International Journal of Obstetrics & Gynaecology
DOI 10.1111/j.1471-0528.2005.00301.x
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Abstract

OBJECTIVE: To investigate the effect of oral iron on postpartum red cell and iron parameters in non-anaemic women with iron deficiency. DESIGN: Randomised study of supplementation with oral iron sulphate 80 mg daily or placebo for 12 weeks starting 24-48 hours after delivery, with visits antepartum and 1, 4, 6 and 12 weeks postpartum. SETTING: Swiss university hospital obstetric unit. PARTICIPANTS: Fifty-two women with antenatal iron deficiency (serum ferritin <15 microg/L) and no antenatal or postnatal anaemia (haemoglobin >11 g/dL up to 48 hours before delivery, and >10 g/dL postpartum), divided into two groups comparable in antenatal iron status. METHODS: Supplementation was started 24-48 hours after delivery (visit 1:V1). Additional tablets were issued one week after V1 (V2), four weeks after V1 (V3) and six weeks after V1 (V4). The last visit took place 12 weeks after visit 1 and 6 weeks after visit 4 (V5). Patients were required to return blisters and boxes whether they were used and unused at each visit and compliance was assessed by counting the tablets. Blood samples for haematology and iron status testing were taken before delivery and at each visit. MAIN OUTCOME MEASURES: Iron status (serum ferritin, hypochromic red cells, iron, transferrin saturation, soluble transferrin receptor concentration); erythropoiesis (standard parameters, including reticulocyte indices); and inflammatory response (serum neopterin, C-reactive protein, white cell count) in five-datapoint profiles. RESULTS: Increased ferritin (P= 0.0004) and transferrin saturation (P= 0.03), decreased soluble transferrin receptors (P= 0.02); increased haemoglobin (P= 0.02) and decreased hypochromic red cells (P= 0.04) compared with placebo at 12 weeks, with no differences in other red cell or reticulocyte parameters. There was a positive correlation between C-reactive protein and postpartum ferritin. No correlation was observed in the puerperium between C-reactive protein and hypochromic red cells or soluble transferrin receptors. CONCLUSIONS: Haemoglobin levels and iron stores in women with term gestational iron deficiency benefit significantly from iron supplementation compared with placebo, even in an industrialised population.

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Crossref · 10.1111/j.1471-0528.2005.00301.x

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  • Leptin is preferentially expressed and secreted by subcutaneous adipose tissue, while adiponectin, visfatin, omentin, resistin, PAI-1, IL-8, IL-7, IL-1a, MCP-1, TGF-b, growth-related oncogene, CCL5 and MIP-1b are expressed more in abdominal fat.

    “Thus, leptin is preferentially expressed and secreted by subcutaneous adipose tissue (52) , while the expression of adiponectin, visfatin, omentin, resistin, PAI-1, IL-8, IL-7, IL-1a, MCP-1, TGF-b, growth-related oncogena, CCL5 and MIP-1b is higher in abdominal fat.”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [53]

  • IL-6 and TNF-a appear to be synthesised equally by different adipose tissue sites.

    “In contrast to such distributions, there are reports that IL-6 and TNF-a seem to be equally synthesised by the different sites (28,36,53 -59) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [53]

  • Adipokine secretion profiles differ between subcutaneous and abdominal adipose tissues.

    “In addition, the profile of adipokines produced is dissimilar between the subcutaneous and abdominal adipose tissues.”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [53]

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Authors
Krafft, A., Perewusnyk, G., Hänseler, E., Quack, K., Huch, R., & Breymann, C.
Affiliations
University Hospital Zurich (CH)
Corresponding author
Breymann, C.
ORCID
Venue
BJOG: An International Journal of Obstetrics & Gynaecology
Publisher
Wiley
Published
2005-02-19
Volume
112
Issue
4
Pages
445-450
ISSN
  • 0306-5456 (ISSN-L)
  • 1470-0328
  • 1471-0528
DOI
10.1111/j.1471-0528.2005.00301.x
OpenAlex
W2082834810
Cited by
35
References
26
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
1.56
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Keywords
iron deficiency, serum ferritin, transferrin saturation, soluble transferrin receptor, erythropoiesis, reticulocytes, C-reactive protein, neopterin, inflammation, postpartum period, hemoglobin
MeSH terms
Iron Deficiencies, Administration, Oral, Adult, C-Reactive Protein, Erythrocytes, Erythropoiesis, Female, Ferritins, Hemoglobins, Humans, Iron, Leukocyte Count, Puerperal Disorders, Tablets, Transferrin, Neopterin

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