Parasitological efficacy of antimalarials in the treatment and prevention of falciparum malaria in pregnancy 1998 to 2009: a systematic review
Abstract
Background Pregnant women are at increased risk from malaria. Resistance to all classes of antimalarials has affected the treatment and prevention of malaria in pregnancy. Objectives To review the therapeutic efficacy of antimalarials used for treatment and intermittent preventive treatment (IPT) in pregnancy. Search strategy We searched MEDLINE and the Cochrane Library between January 1998 and December 2009 for publications using the medical subject headings: efficacy, antimalarials, malaria, pregnancy, pharmacokinetics, treatment, IPT and placenta positive. In May 2010 we searched the register of clinical trials (http://clinicaltrials.gov/) and of WHO (http://apps.who.int/trialsearch/) using 'malaria', and 'pregnancy' and 'treatment'. Selection criteria We identified 233 abstracts, reviewed 83 full text articles and included 60 studies. Data collection and analysis Two authors entered extracted data to an excel spreadsheet. Main results Parasitological failure rates, placenta positivity rates (assessed by microscopy) or both were reported in 44% (21/48), 46% (22/48) and 10% (5/48) of articles, respectively. Most pharmacokinetic studies (9/12) suggested dose optimisation. In 23 treatment studies 17 different antimalarial drugs were delivered in 53 study arms; 43.4% (23/53) reported a failure rate of 10% in 68% (23/34) of SP trial arms and > 15% in all seven chloroquine arms. The ACT provided lower parasitological failure and gametocyte carriage rates. Author's conclusions Dr…
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A recent review of treatment studies carried out in pregnant women from 1998-2009 reported a parasitological failure >5% in 3 out of 11 trials.
“A recent review of treatment studies carried out in pregnant women from 1998–2009, reported a parasitological failure >5% in 3 out of 11 trials.132”
From Malaria in pregnancy. (2013) · cites this paper as [132]
Cites
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Malaria in pregnancy in the Asia-Pacific region
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Cohort Profile: the SMRU Refugee and Migrant Pregnancy Study in Western Thailand and Eastern Myanmar
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- Authors
- McGready, R., White, N., & Nosten, F.
- Affiliations
- Mahidol University (TH)
- Churchill Hospital (GB)
- Corresponding author
- McGready, R
- ORCID
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 2010-12-15
- Volume
- 118
- Issue
- 2
- Pages
- 123-135
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W1603335376
- Cited by
- 54
- References
- 10
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 6 · 2012: 13
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (093956)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pharmaceutical Quality and Counterfeiting
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
- Keywords
- falciparum malaria, malaria in pregnancy, antimalarial drugs, intermittent preventive treatment, parasitological cure rate, sulfadoxine-pyrimethamine, artemisinin-based combination therapy, chloroquine, antimalarial drug resistance, gametocyte carriage, pharmacokinetics, dose optimization
- MeSH terms
- Antimalarials, Drug Therapy, Combination, Female, Humans, Placenta, Pregnancy, Pregnancy Complications, Parasitic, Randomized Controlled Trials as Topic, Malaria, Falciparum, Treatment Outcome, Drug Resistance, Multiple
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