Artemisinin Antimalarials in Pregnancy: A Prospective Treatment Study of 539 Episodes of Multidrug‐Resistant Plasmodium falciparum
Abstract
The emergence and spread of multidrug-resistant Plasmodium falciparum compromises the treatment of malaria, especially during pregnancy, where the choice of antimalarials is already limited. Artesunate (n=528) or artemether (n=11) was used to treat 539 episodes of acute P. falciparum malaria in 461 pregnant women, including 44 first-trimester episodes. Most patients (310 [57.5%]) received re-treatments after earlier treatment with quinine or mefloquine. By use of survival analysis, the cumulative artemisinin failure rate for primary infections was 6.6% (95% confidence interval, 1.0-12.3), compared with the re-treatment failure rate of 21.7% (95% confidence interval, 15.4-28.0; P=.004). The artemisinins were well tolerated with no evidence of adverse effects. Birth outcomes did not differ significantly to community rates for abortion, stillbirth, congenital abnormality, and mean gestation at delivery. These results are reassuring, but further information about the safety of these valuable antimalarials in pregnancy is needed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cumulative failure rate reported in only one study was 6.6% across all trimesters (n=461).
“and the cumulative failure rate reported in only one study was 6.6% across all trimesters (n=461).118”
From Malaria in pregnancy. (2013) · cites this paper as [118]
Artemisinin derivatives were relatively safe (n=1937) in the first trimester of pregnancy.
“Artemisinin derivatives were relatively safe (n=1937) in the first trimester of pregnancy42,118–119 and the cumulative failure rate reported in only one study was 6.6% across all trimesters (n=461).118”
From Malaria in pregnancy. (2013) · cites this paper as [118]
Cites
World Health Organization (2000) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(00)90300-6 · Cited by 1,083 · see citing works
Antimalarial drug resistance and combination chemotherapy
White, N. J. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0426 · Cited by 477 · see citing works
Self-citationEffects of artemisinin derivatives on malaria transmissibility
Price, R. N., Nosten, F. H., Luxemburger, C., ter Kuile, F. O., Paiphun, L., Price, R. N., Luxemburger, C., Chongsuphajaisiddhi, T., White, N. J., Price, R. N., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91488-9 · Cited by 462 · see citing works
Self-citationThe epidemiology of severe malaria in an area of low transmission in Thailand.
Luxemburger, C., Ricci, F., Nosten, F., Raimond, D., Bathet, S., & White, N. J. (1997) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(97)90066-3 · Cited by 299 · see citing works
Self-citationMalaria during pregnancy in an area of unstable endemicity.
Nosten, F., ter Kuile, F., Maelankirri, L., Decludt, B., & White, N. J. (1991) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(91)90205-d · Cited by 294 · cited 1× · see citing works
“This has resulted in a significant reduction in maternal death from malaria [12].”
BackgroundSelf-citationAntimalarial drug resistance: the pace quickens
White, N. J. (1992) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/30.5.571 · Cited by 281 · see citing works
Self-citationThe Effects of Mefloquine Treatment in Pregnancy
Nosten, F. H., Vincenti, M., Simpson, J. A., Yei, P., Thwai, K. L., de Vries, A., Chongsuphajaisiddhi, T., & White, N. J. (1999) · Clinical Infectious Diseases · doi:10.1086/515183 · Cited by 133 · see citing works
Self-citationExamination of some factors responsible for a food‐induced increase in absorption of atovaquone.
Rolan, P., Mercer, A., Weatherley, B., Holdich, T., Meire, H., Peck, R., Ridout, G., & Posner, J. (1994) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1994.tb04232.x · Cited by 123 · see citing works
McGready, R., Brockman, A., Cho, T., Cho, D., van Vugt, M., Luxemburger, C., Chongsuphajaisiddhi, T., White, N. J., & Nosten, F. (2000) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(00)90235-9 · Cited by 110 · see citing works
Self-citationArtemisinin derivatives in the treatment of falciparum malaria in pregnancy
McGready, R. M., Cho, T., Cho, J. J., Simpson, J. A., Luxemburger, C., Dubowitz, L. M. S., Looareesuwan, S., White, N. J., & Nosten, F. H. (1998) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(98)91081-1 · Cited by 100 · see citing works
Self-citationSymptoms During Normal Pregnancy: A Prospective Controlled Study
Zib, M., Lim, L. L., & Walters, W. A. W. (1999) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.1999.tb03122.x · Cited by 75 · see citing works
Quinine induces reversible high‐tone hearing loss.
Roche, R. J., Silamut, K., Pukrittayakamee, S., Looareesuwan, S., Molunto, P., Boonamrung, S., & White, N. J. (1990) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1990.tb03704.x · Cited by 48 · see citing works
Self-citationMcGready, R. M., Cho, T., Hkirijaroen, L., Simpson, J. A., Chongsuphajaisiddhi, T., White, N. J., & Nosten, F. H. (1998) · Annals of Tropical Medicine and Parasitology · doi:10.1080/00034983.1998.11813324 · Cited by 47 · see citing works
Self-citationWang, T. Y. (1989) · PubMed · Cited by 32 · see citing works
Neuropsychiatric Adverse Effects of Mefloquine
Nosten, F. H., & van Vugt, M. (1999) · CNS Drugs · doi:10.2165/00023210-199911010-00001 · Cited by 26 · see citing works
Self-citationA study of the consequences of malarial infection in pregnant women and their infants.
Brabin, B. J., Maxwell, S. L., Chimsuku, L., Verhoeff, F. H., Hj, V. D. K., Broadhead, R., Kazembe, P., & Thomas, A. (1993) · PubMed · Cited by 24 · see citing works
Clinical trials on qinghaosu and its derivatives
Cook, G. C. (1992) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(92)90202-n · Cited by 21 · see citing works
Glucose tolerance in pregnant patients with acute falciparum malaria
Davis, T. M. E., Supanaranond, W., Pukrittayakamee, S., Chanond, L., & White, N. J. (1993) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(93)90280-4 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
1 of the 19 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Artemisinin-Based Combination Treatment of Falciparum Malaria
Nosten, F. H., & White, N. J. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.181 · Cited by 663 · see citing works
Self-citationArtemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
Eastman, R. T., & Fidock, D. A. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2239 · Cited by 569 · see citing works
Taylor, W. R. J., & White, N. J. (2004) · Drug Safety · doi:10.2165/00002018-200427010-00003 · Cited by 479 · see citing works
Self-citationWiesner, J., Ortmann, R., Jomaa, H., & Schlitzer, M. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200200569 · Cited by 431 · see citing works
Current perspectives on the mechanism of action of artemisinins
Golenser, J., Waknine-Grinberg, J. H., Krugliak, M., Hunt, N. H., & Grau, G. E. (2006) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.07.011 · Cited by 324 · see citing works
Intermittent Presumptive Treatment for Malaria
White, N. J. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020003 · Cited by 269 · see citing works
Self-citationArtesunate versus quinine for treating severe malaria
Sinclair, D., Donegan, S., Isba, R., & Lalloo, D. G. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005967.pub4 · Cited by 236 · see citing works
McGready, R., Lee, S., Wiladphaingern, J., Ashley, E., Rijken, M., Boel, M., Simpson, J., Paw, M., Pimanpanarak, M., Mu, O., et al. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70339-5 · Cited by 228 · see citing works
Self-citationWoodrow, C. J., Haynes, R. K., & Krishna, S. (2005) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.028399 · Cited by 204 · see citing works
Reducing the burden of malaria in pregnancy by preventive strategies
Menéndez, C., D'Alessandro, U., & ter Kuile, F. O. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70024-5 · Cited by 188 · see citing works
Takem, E. N., & D'Alessandro, U. (2013) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2013.010 · Cited by 185 · see citing works
Malaria in pregnancy and the endemicity spectrum: what can we learn?
Nosten, F. H., Rogerson, S. J., Beeson, J. G., McGready, R. M., Mutabingwa, T. K., & Brabin, B. J. (2004) · Trends in Parasitology · doi:10.1016/j.pt.2004.06.007 · Cited by 184 · see citing works
Self-citationArtesunate for the Treatment of Severe Falciparum Malaria
Rosenthal, P. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmct0709050 · Cited by 181 · see citing works
Newman, R. D., Parise, M. E., Slutsker, L., Nahlen, B. L., & Steketee, R. W. (2003) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.2003.01066.x · Cited by 168 · see citing works
Antimalarial Drugs in Pregnancy: A Review
Nosten, F. H., McGready, R. M., D’Alessandro, U., Bonell, A., Verhoeff, F. H., Menéndez, C., Mutabingwa, T., & Brabin, B. J. (2006) · Current Drug Safety · doi:10.2174/157488606775252584 · Cited by 163 · see citing works
Self-citationTHE CONTRIBUTION OF MALARIA IN PREGNANCY TO PERINATAL MORTALITY
Geertruyden, J. V., Thomas, F., Erhart, A., & D’ALESSANDRO, U. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.71.35 · Cited by 162 · see citing works
Combination Therapy for Malaria
Nosten, F. H., & Brasseur, P. (2002) · Drugs · doi:10.2165/00003495-200262090-00003 · Cited by 145 · see citing works
Self-citationDevelopmental toxicity of artesunate and an artesunate combination in the rat and rabbit
Clark, R. L., White, T. E. K., Clode, S. A., GAUNT, I. F., Winstanley, P., & Ward, S. A. (2004) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20027 · Cited by 142 · see citing works
The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria
McGready, R., Stepniewska, K., Edstein, M. D., Cho, T., Gilveray, G., Looareesuwan, S., White, N. J., & Nosten, F. (2003) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-003-0652-9 · Cited by 138 · see citing works
Self-citationMcGready, R., Tan, S. O., Ashley, E. A., Pimanpanarak, M., Viladpai-nguen, J., Phaiphun, L., Wüstefeld, K., Barends, M., Laochan, N., Keereecharoen, L., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050253 · Cited by 136 · see citing works
Self-citationHow do patients use antimalarial drugs? A review of the evidence
Yeung, S., & White, N. J. (2005) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2004.01364.x · Cited by 124 · see citing works
Self-citationArtemether/lumefantrine in the treatment of uncomplicated falciparum malaria
Kokwaro, G. O., Mwai, L., & Nzila, A. M. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.1.75 · Cited by 120 · see citing works
Antimalarial compounds: from bench to bedside
Olliaro, P., & Taylor, W. R. J. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00653 · Cited by 117 · see citing works
McGready, R., Stepniewska, K., Lindegardh, N., Ashley, E. A., La, Y., Singhasivanon, P., White, N. J., & Nosten, F. (2006) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-006-0199-7 · Cited by 115 · see citing works
Self-citationClark, R. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.05.002 · Cited by 117 · see citing works
The potential for interactions between antimalarial and antiretroviral drugs
Khoo, S., Back, D. J., & Winstanley, P. (2005) · AIDS · doi:10.1097/01.aids.0000174445.40379.e0 · Cited by 115 · see citing works
Efficacy and safety of dihydroartemisinin-piperaquine
Myint, H. Y., Ashley, E. A., Day, N., Nosten, F. H., & White, N. J. (2007) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2007.05.018 · Cited by 110 · see citing works
Self-citationKarunajeewa, H., Lim, C., Hung, T., Ilett, K. F., Denis, M. B., Socheat, D., & Davis, T. M. E. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01962.x · Cited by 108 · see citing works
Mayor, A., Serra-Casas, E., Bardají, A., Sanz, S., Puyol, L., Cisteró, P., Sigauque, B., Mandomando, I., Aponte, J. J., Alonso, P. L., et al. (2009) · Malaria Journal · doi:10.1186/1475-2875-8-9 · Cited by 105 · see citing works
In Vivo Assessment of Drug Efficacy against Plasmodium falciparum Malaria: Duration of Follow-Up
Stepniewska, K., Taylor, W. R. J., Mayxay, M., Price, R. N., Smithuis, F. M., Guthmann, J., Barnes, K. I., Myint, H. Y., Adjuik, M., Olliaro, P., et al. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.11.4271-4280.2004 · Cited by 105 · see citing works
Self-citationSynthesis, characterization and antimalarial activity of quinoline–pyrimidine hybrids
Pretorius, S. I., Breytenbach, W. J., de Kock, C. A., Smith, P. J., & N’Da, D. D. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.10.019 · Cited by 102 · see citing works
McGready, R., Stepniewska, K., Ward, S. A., Cho, T., Gilveray, G., Looareesuwan, S., White, N. J., & Nosten, F. (2006) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-006-0118-y · Cited by 101 · see citing works
Self-citationArtesunate versus quinine for treating severe malaria
Sinclair, D., Donegan, S., & Lalloo, D. G. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005967.pub3 · Cited by 94 · see citing works
The safety of artemisinins during pregnancy: a pressing question
Dellicour, S., Hall, S. T., Chandramohan, D., & Greenwood, B. M. (2007) · Malaria Journal · doi:10.1186/1475-2875-6-15 · Cited by 92 · see citing works
Case management of malaria in pregnancy
Nosten, F. H., McGready, R. M., & Mutabingwa, T. K. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70023-3 · Cited by 88 · see citing works
Self-citationDuffy, P. E., & Fried, M. (2005) · Springer eBooks · doi:10.1007/3-540-29088-5_7 · Cited by 86 · see citing works
Moore, K. A., Simpson, J. A., Paw, M. K., Pimanpanarak, M., Wiladphaingern, J., Rijken, M. J., Jittamala, P., White, N. J., Fowkes, F. J. I., Nosten, F., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00547-2 · Cited by 84 · see citing works
Self-citationEffects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro
Longo, M., Zanoncelli, S., Manera, D., Brughera, M., Colombo, P., Lansen, J., Mazué, G., Gomes, M. F., Taylor, W. R. J., & Olliaro, P. (2005) · Reproductive Toxicology · doi:10.1016/j.reprotox.2005.05.005 · Cited by 84 · see citing works
Wartenberg, M., Wolf, S., Budde, P., Grünheck, F., Acker, H., Hescheler, J., Wartenberg, G., & Sauer, H. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000098424.38003.ff · Cited by 80 · see citing works
White, T., Bushdid, P., Ritter, S. H., Laffan, S. B., & Clark, R. (2006) · Birth defects research. Part B. Developmental and reproductice toxicology · doi:10.1002/bdrb.20092 · Cited by 77 · see citing works
Kalilani, L., Mofolo, I., Chaponda, M., Rogerson, S. J., Alker, A. P., Kwiek, J. J., & Meshnick, S. R. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001166 · Cited by 75 · see citing works
Therapy of Falciparum Malaria in Sub-Saharan Africa: from Molecule to Policy
Winstanley, P., Ward, S., Snow, R., & Breckenridge, A. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.3.612-637.2004 · Cited by 89 · see citing works
Longo, M., Zanoncelli, S., Torre, P. D., Riflettuto, M., Cocco, F., Pesenti, M., Giusti, A. M., Colombo, P., Brughera, M., Mazué, G., et al. (2006) · Reproductive Toxicology · doi:10.1016/j.reprotox.2006.08.001 · Cited by 74 · see citing works
Kremsner, P. G., Ramharter, M., Oyakhirome, S., Klouwenberg, P. M. C. K., Adégnika, A. A., Agnandji, S., Missinou, M. A., Matsiegui, P., Mordmüller, B. G., Borrmann, S., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/430309 · Cited by 73 · see citing works
Malaria: an update on current chemotherapy
Visser, B. J., van Vugt, M., & Grobusch, M. P. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.944499 · Cited by 72 · see citing works
Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed?
Vallely, A. J., Vallely, L. M., Changalucha, J. M., Greenwood, B. M., & Chandramohan, D. (2007) · Malaria Journal · doi:10.1186/1475-2875-6-16 · Cited by 72 · see citing works
Estimation of gestational age from fundal height: a solution for resource-poor settings
White, L. J., Lee, S. J., Stepniewska, K., Simpson, J. A., Dwell, S. L. M., Arunjerdja, R., Singhasivanon, P., White, N. J., Nosten, F., & McGready, R. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2011.0376 · Cited by 71 · see citing works
Self-citationArtesunate: developmental toxicity and toxicokinetics in monkeys.
Clark, R., Arima, A., Makori, N., Nakata, Y., Bernard, F., Gristwood, W., Harrell, A., White, T., & Wier, P. (2008) · Birth defects research. Part B. Developmental and reproductice toxicology · doi:10.1002/bdrb.20163 · Cited by 70 · see citing works
Manyando, C., Mkandawire, R., Puma, L., Sinkala, M., Mpabalwani, E., Njunju, E., Gomes, M., Ribeiro, I., Walter, V., Virtanen, M., et al. (2010) · Malaria Journal · doi:10.1186/1475-2875-9-249 · Cited by 67 · see citing works
Treating Severe Malaria in Pregnancy: A Review of the Evidence
Kovacs, S. D., Rijken, M. J., & Stergachis, A. (2015) · Drug Safety · doi:10.1007/s40264-014-0261-9 · Cited by 66 · see citing works
Wiesner, J., Ortmann, R., Jomaa, H., & Schlitzer, M. (2003) · Angewandte Chemie · doi:10.1002/ange.200200569 · Cited by 64 · see citing works
McGready, R., Keo, N. K., Villegas, L., White, N. J., Looareesuwan, S., & Nosten, F. (2003) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(03)80040-8 · Cited by 64 · see citing works
Self-citationManyando, C., Kayentao, K., D’Alessandro, U., Okafor, H. U., Juma, E., & Hamed, K. (2012) · Malaria Journal · doi:10.1186/1475-2875-11-141 · Cited by 62 · see citing works
Whitty, C. W. M., Edmonds, S., & Mutabingwa, T. K. (2005) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2005.00714.x · Cited by 62 · see citing works
Efficacy and safety of artemether against a natural Fasciola hepatica infection in sheep
Keiser, J., Rinaldi, L., Veneziano, V., Mezzino, L., Tanner, M., Utzinger, J., & Cringoli, G. (2008) · Parasitology Research · doi:10.1007/s00436-008-0998-0 · Cited by 62 · see citing works
Coartemether (artemether and lumefantrine): an oral antimalarial drug
Wernsdorfer, W. H. (2004) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2.2.181 · Cited by 60 · see citing works
Antimalarial drugs for treating and preventing malaria in pregnant and lactating women
Saito, M., Gilder, M. E., McGready, R. M., & Nosten, F. H. (2018) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2018.1535593 · Cited by 58 · see citing works
Self-citationNa‐Bangchang, K., Manyando, C., Ruengweerayut, R., Kioy, D. W., Mulenga, M., Miller, G. B., & Konsil, J. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0969-7 · Cited by 58 · see citing works
Sensitive periods for developmental toxicity of orally administered artesunate in the rat.
White, T., & Clark, R. (2008) · Birth defects research. Part B. Developmental and reproductice toxicology · doi:10.1002/bdrb.20157 · Cited by 64 · see citing works
Fairhurst, R. M., & Wellems, T. (2010) · Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases · doi:10.1016/b978-0-443-06839-3.00275-7 · Cited by 41 · see citing works
Safety profile of Coartem®: the evidence base
Falade, C. O., & Manyando, C. (2009) · Malaria Journal · doi:10.1186/1475-2875-8-s1-s6 · Cited by 55 · see citing works
McGready, R., White, N., & Nosten, F. (2011) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2010.02810.x · Cited by 54 · see citing works
Self-citationMutabingwa, T. K., Muze, K., Ord, R., Briceño, M., Greenwood, B. M., Drakeley, C., & Whitty, C. J. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005138 · Cited by 53 · see citing works
Drugs for treating uncomplicated malaria in pregnant women
Orton, L., & Omari, A. A. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004912.pub3 · Cited by 52 · see citing works
Ashley, E. A., McGready, R. M., Proux, S., & Nosten, F. H. (2005) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2005.06.009 · Cited by 51 · see citing works
Self-citationZongo, I., Dorsey, G., Rouamba, N., Dokomajilar, C., LANKOANDE, Z. M., Ouédraogo, J., & Rosenthal, P. J. (2005) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2005.73.826 · Cited by 48 · see citing works
Dellicour, S., ter Kuile, F. O., & Stergachis, A. S. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050187 · Cited by 45 · see citing works
Toxicity of artemisinin [Artemisia annua L.] in two different periods of pregnancy in Wistar rats
Boareto, A. C., Müller, J. C., Bufalo, A. C., Botelho, G. G. K., de Araújo, S. L., Foglio, M. A., de Morais, R. N., & Dalsenter, P. R. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.11.003 · Cited by 44 · see citing works
Artemether in the treatment of falciparum malaria during pregnancy in eastern Sudan
Adam, I., Elwasila, E. T., Ali, D. A. M., Elansari, E., & Elbashir, M. I. (2004) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2003.11.008 · Cited by 43 · see citing works
Artesunate versus quinine for treating severe malaria
Jones, K. L., Donegan, S., & Lalloo, D. G. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005967.pub2 · Cited by 42 · see citing works
Etiology and Therapeutic Management of Erythema Nodosum During Pregnancy: An Update
Acosta, K. A., Haver, M. C., & Kelly, B. C. (2013) · American Journal of Clinical Dermatology · doi:10.1007/s40257-013-0024-x · Cited by 41 · see citing works
Safety of artemisinins during early pregnancy, assessed in 62 Sudanese women
Adam, I., Elhassan, E. M., Omer, E. M., Abdulla, M. A., Mahgoub, H. M., & Adam, G. K. (2009) · Annals of Tropical Medicine & Parasitology · doi:10.1179/136485909x398285 · Cited by 40 · see citing works
Winstanley, P., & Ward, S. A. (2006) · Advances in Parasitology/Advances in parasitology · doi:10.1016/s0065-308x(05)61002-0 · Cited by 40 · see citing works
Adam, I., Ali, D. M., & Abdalla, M. A. (2006) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2005.09.019 · Cited by 38 · see citing works
Li, Q., & Weina, P. J. (2009) · Molecules · doi:10.3390/molecules15010040 · Cited by 37 · see citing works
Muehlenbachs, A., Nabasumba, C., McGready, R., Turyakira, E., Tumwebaze, B., Dhorda, M., Nyehangane, D., Nalusaji, A., Nosten, F., Guerin, P. J., et al. (2012) · Malaria Journal · doi:10.1186/1475-2875-11-150 · Cited by 35 · see citing works
Self-citationSaito, M., Gilder, M. E., Nosten, F. H., McGready, R. M., & Guerin, P. J. (2017) · Malaria Journal · doi:10.1186/s12936-017-2135-y · Cited by 35 · see citing works
Self-citationClark, R. (2012) · Birth defects research. Clinical and molecular teratology · doi:10.1002/bdra.22868 · Cited by 29 · see citing works
Bardají, A., Bassat, Q., Alonso, P. L., & Menéndez, C. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.703651 · Cited by 32 · see citing works
Longo, M., Zanoncelli, S., Torre, P. D., Rosa, F. G. D., Giusti, A. M., Colombo, P., Brughera, M., Mazué, G., & Olliaro, P. (2008) · Reproductive Toxicology · doi:10.1016/j.reprotox.2008.02.004 · Cited by 32 · see citing works
Kovacs, S., van Eijk, A. M., Sevene, E., Dellicour, S., Weiss, N. S., Emerson, S. S., Steketee, R. W., ter Kuile, F. O., & Stergachis, A. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164963 · Cited by 32 · see citing works
Nambozi, M., Tinto, H., Mwapasa, V., Tagbor, H. K., Kabuya, J.-B. B., Hachizovu, S., Traoré‐Coulibaly, M., Valéa, I., Tahita, M. C., Ampofo, G. D., et al. (2019) · Malaria Journal · doi:10.1186/s12936-019-2737-7 · Cited by 30 · see citing works
Clinical and non-clinical safety of artemisinin derivatives in pregnancy
Gomes, C., Boareto, A. C., & Dalsenter, P. R. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.08.003 · Cited by 30 · see citing works
Patterns of anti-malarial drug treatment among pregnant women in Uganda
Sangaré, L. R., Weiss, N. S., Brentlinger, P. E., Richardson, B. A., Staedke, S. G., Kiwuwa, M. S., & Stergachis, A. S. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-152 · Cited by 29 · see citing works
Malaria Pharmacovigilance in Africa
Mehta, U. C., Dürrheim, D. N., Mabuza, A. M., Blumberg, L. H., Allen, E., & Barnes, K. I. (2007) · Drug Safety · doi:10.2165/00002018-200730100-00008 · Cited by 28 · see citing works
Saito, M., Gilder, M. E., Nosten, F. H., Guerin, P. J., & McGready, R. M. (2017) · Malaria Journal · doi:10.1186/s12936-017-2136-x · Cited by 27 · see citing works
Self-citationBassi, P. U., Osakwe, A. I., Ogar, C. K., Elagbaje, C., Nwankwo, B. B., Balogun, S. T., Ntadom, G. N., & Isah, A. O. (2017) · Pharmacology Research & Perspectives · doi:10.1002/prp2.302 · Cited by 26 · see citing works
Tarantola, A., Rachline, A., Konto, C., Houozé, S., Sabah-Mondan, C., Vrillon, H., Bouvet, É., & Geres, T. (2005) · Scandinavian Journal of Infectious Diseases · doi:10.1080/23744235.2019.12062304 · Cited by 26 · see citing works
Yasuoka, J., Kikuchi, K., Nanishi, K., Ly, P., Thavrin, B., Omatsu, T., & Mizutani, T. (2018) · BMC Public Health · doi:10.1186/s12889-018-6123-0 · Cited by 25 · see citing works
Li, Q., Si, Y., Smith, K. S., Zeng, Q., & Weina, P. J. (2008) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20164 · Cited by 25 · see citing works
Malaria and the pregnant traveller
McGready, R. M., Ashley, E. A., & Nosten, F. H. (2004) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2004.03.008 · Cited by 24 · see citing works
Self-citationBallard, S.-B., Salinger, A., MPHc, Arguin, P. M., Desai, M., & Tan, K. R. (2018) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6714a4 · Cited by 24 · see citing works
Artesunate, artemether or quinine in severePlasmodium falciparummalaria?
Checkley, A. M., & Whitty, C. W. M. (2007) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.5.2.199 · Cited by 24 · see citing works
Malaria in pregnancy: clinical, therapeutic and prophylactic considerations
GITAU, G. M., & Eldred, J. M. (2005) · The Obstetrician & Gynaecologist · doi:10.1576/toag.7.1.005.27036 · Cited by 23 · see citing works
Developmental and reproductive toxicity studies on artemisone
Schmuck, G., Klaus, A. ‐., Krötlinger, F., & Langewische, F. W. (2009) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20192 · Cited by 23 · see citing works
Fairhurst, R. M., & Wellems, T. E. (2015) · Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases · doi:10.1016/b978-1-4557-4801-3.00276-9 · Cited by 23 · see citing works
Drugs for treating uncomplicated malaria in pregnant women
Orton, L., & Garner, P. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004912.pub2 · Cited by 22 · see citing works
Assessment of safety of the major antimalarial drugs
Chattopadhyay, R., Mahajan, B., & Kumar, S. (2007) · Expert Opinion on Drug Safety · doi:10.1517/14740338.6.5.505 · Cited by 21 · see citing works
Medhin, A., Jima, D., Tesfaye, G., Kebede, A., Argaw, D., & Babaniyi, O. A. (2006) · East African Medical Journal · doi:10.4314/eamj.v82i8.9321 · Cited by 21 · see citing works
White, N. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4470-3.50077-x · Cited by 21 · see citing works
Self-citation
- Authors
- McGready, R., Cho, T., Keo, N. K., Thwai, K. L., Villegas, L., Looareesuwan, S., White, N. J., & Nosten, F.
- Affiliations
- Mahidol University (TH)
- Shoklo Malaria Research Unit (TH)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-12-15
- Volume
- 33
- Issue
- 12
- Pages
- 2009-2016
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2170827091
- Cited by
- 178
- References
- 19
- Citations by year
- 2026: 2 · 2023: 10 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 9
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pharmaceutical Quality and Counterfeiting
- Keywords
- artemether, artesunate, Plasmodium falciparum, multidrug resistance, malaria in pregnancy, antimalarial treatment failure, birth outcomes, drug safety in pregnancy
- MeSH terms
- Animals, Antimalarials, Female, Humans, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Prospective Studies, Sesquiterpenes, Malaria, Falciparum, Treatment Outcome, Drug Resistance, Multiple, Artemisinins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
