The DOI matches its Crossref record.
TYROSINE HYDROXYLASE IN RAT BRAIN: DEVELOPMENTAL CHARACTERISTICS
Abstract
Abstract— The development of tyrosine hydroxylase (tyrosine 3‐hydroxylase, EC 1.14.3.a) activity has been examined in whole rat brain and in various regions and subcellular fractions thereof. The specific activity of tyrosine hydroxylase increased almost 15‐fold from 15 days of gestation to adulthood. With maturation, those regions of the brain that contain only terminals of the catecholaminergic neurons showed the greatest increases in enzyme activity. There was a shift in the subcellular distribution of tyrosine hydroxylase from the soluble fraction in the fetal brain to the synaptosomal fraction in the adult brain. Tyrosine hydroxylase, dopamine hydroxylase (EC 1.14.2.1) and the specific uptake mechanism for norepinephrine appear to develop in a coordinated fashion.
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Citations
Cited by
Neurochemical aspects of the ontogenesis of cholinergic neurons in the rat brain
Coyle, J. T., & Yamamura, H. I. (1976) · Brain Research · doi:10.1016/0006-8993(76)90310-3 · Cited by 730
Self-citationLauder, J. M., & Bloom, F. E. (1974) · Journal of Comparative Neurology · doi:10.1002/cne.901550407 · Cited by 655
Shaywitz, B. A., Yager, R. D., & Klopper, J. H. (1976) · Science · doi:10.1126/science.942800 · Cited by 403
Creese, I., & Iversen, S. D. (1973) · Brain Research · doi:10.1016/0006-8993(73)90302-8 · Cited by 353
Specht, L. A., Pickel, V. M., Joh, T. H., & Reis, D. J. (1981) · Journal of Comparative Neurology · doi:10.1002/cne.901990207 · Cited by 353
Metadata
- Authors
- Coyle, J. T., & Axelrod, J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1972-04
- Volume
- 19
- Issue
- 4
- Pages
- 1117-1123
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2122799346
- Cited by
- 260
- References
- 0
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: TYROSINE HYDROXYLASE IN RAT BRAIN: DEVELOPMENTAL CHARACTERISTICS. https://app.cochat.ai/papers/10.1111/j.1471-4159.1972.tb01431.x
- The paper
- Coyle, J. T., & Axelrod, J. (1972). TYROSINE HYDROXYLASE IN RAT BRAIN: DEVELOPMENTAL CHARACTERISTICS. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1972.tb01431.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
