The DOI matches its Crossref record.
PLASMA CHOLINE: ITS TURNOVER AND EXCHANGE WITH BRAIN CHOLINE
Abstract
—The kinetics of plasma choline (Ch) and the uptake of plasma Ch into the brain were studied by means of intravenous infusion of [2H4]Ch at various rates into anaesthetized and conscious rats. [2H4]Ch levels in both arterial and venous plasma at steady state were linearly related to the infusion rate; however, unlabelled Ch levels were independent of infusion rate. [2H4]Ch levels were higher in the arterial plasma than in the venous plasma, while unlabelled Ch levels were higher in the venous plasma than in the arterial plasma. It was concluded that Ch is being generated in the brain and is released into the venous effluent. The supply of Ch to the plasma is not decreased if the plasma Ch level is increased. The clearance and turnover of Ch in the compartment of its initial distribution are 75 ml kg-1 min-1 and 716 nmol kg-1 min-1, respectively. The uptake of plasma Ch into the brain is not saturated even at very high levels of plasma Ch.
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Citations
Cited by
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
Brain Acetylcholine: Control by Dietary Choline
Cohen, E. L., & Wurtman, R. J. (1976) · Science · doi:10.1126/science.1251187 · Cited by 388
Metadata
- Authors
- Freeman, J. J., Choi, R. L., & Jenden, D. J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1975-04
- Volume
- 24
- Issue
- 4
- Pages
- 729-734
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W4250706760
- Cited by
- 189
- References
- 0
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: PLASMA CHOLINE: ITS TURNOVER AND EXCHANGE WITH BRAIN CHOLINE. https://app.cochat.ai/papers/10.1111/j.1471-4159.1975.tb11671.x
- The paper
- Freeman, J. J., Choi, R. L., & Jenden, D. J. (1975). PLASMA CHOLINE: ITS TURNOVER AND EXCHANGE WITH BRAIN CHOLINE. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1975.tb11671.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
