The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Brain Acetylcholine: Control by Dietary Choline
Abstract
Acetylcholine concentrations in whole rat brain or in various brain regions and free choline concentrations in blood serum and brain vary with dietary choline consumption. The increases in brain acetylcholine after treatment with physostigmine (an inhibitor of acetylcholinesterase) or after consumption of a diet high in choline are additive, suggesting that choline acts by increasing acetylcholine synthesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Brain Catechol Synthesis: Control by Brain Tyrosine Concentration
Wurtman, R. J., Larin, F., Mostafapour, S., & Fernstrom, J. D. (1974) · Science · doi:10.1126/science.185.4146.183 · Cited by 367
Self-citationBrain acetylcholine: Increase after systematic choline administration
Cohen, E. L., & Wurtman, R. J. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90194-0 · Cited by 333
Self-citationTHE FORMATION OF ACETYLCHOLINE. A NEW ENZYME: "CHOLINE ACETYLASE"
Nachmansohn, D., & Machado, A. L. (1943) · Journal of Neurophysiology · doi:10.1152/jn.1943.6.5.397 · Cited by 329
PLASMA CHOLINE: ITS TURNOVER AND EXCHANGE WITH BRAIN CHOLINE
Freeman, J. J., Choi, R. L., & Jenden, D. J. (1975) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1975.tb11671.x · Cited by 189
Impulse-flow regulation of high affinity choline uptake in brain cholinergic nerve terminals
SIMON, J. R., & KUHAR, M. J. (1975) · Nature · doi:10.1038/255162a0 · Cited by 180
PURIFICATION AND PROPERTIES OF CHOLINE ACETYLTRANSFERASE FROM OX BRAIN STRIATE NUCLEI
Glover, V. A. S., & Potter, L. T. (1971) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1971.tb11987.x · Cited by 159
Acetylcholine Concentrations in Rat Brain: Diurnal Oscillation
Hanin, I., MASSARELLI, R., & Costa, E. (1970) · Science · doi:10.1126/science.170.3955.341 · Cited by 128
Ostwald, P. F., & Peltzman, P. (1974) · Scientific American · doi:10.1038/scientificamerican0374-84 · Cited by 118
CONTROL OF ACETYLCHOLINE SYNTHESIS—THE INHIBITION OF CHOLINE ACETYLTRANSFERASE BY ACETYLCHOLINE
Kaita, A. A., & Goldberg, A. M. (1969) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1969.tb05964.x · Cited by 104
An enzymatic method for measuring picomole quantities of acetylcholine and choline in CNS tissue
Shea, P. A., & Aprison, M. H. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90181-4 · Cited by 91
Cited by
Perry, E. K., Tomlinson, B. E., Blessed, G., Bergmann, K., Gibson, P. H., & Perry, R. H. (1978) · BMJ · doi:10.1136/bmj.2.6150.1457 · Cited by 2,042
Choline: Critical Role During Fetal Development and Dietary Requirements in Adults
Zeisel, S. H. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111156 · Cited by 741
Human Serial Learning: Enhancement with Arecholine and Choline Impairment with Scopolamine
Sitaram, N., Weingartner, H., & Gillin, J. C. (1978) · Science · doi:10.1126/science.351808 · Cited by 524
Rossor, M. N. (1982) · The Lancet · doi:10.1016/s0140-6736(82)91212-0 · Cited by 283
Age-Related Changes in Passive Avoidance Retention: Modulation with Dietary Choline
Bartus, R. T., Dean, R. L., Goas, J. A., & Lippa, A. S. (1980) · Science · doi:10.1126/science.7384805 · Cited by 275
Metadata
- Authors
- Cohen, E. L., & Wurtman, R. J.
- Venue
- Science
- Published
- 1976-02-13
- Volume
- 191
- Issue
- 4227
- Pages
- 561-562
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012856769
- Cited by
- 388
- References
- 13
- FWCI
- 30.94
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Brain Acetylcholine: Control by Dietary Choline. https://app.cochat.ai/papers/10.1126/science.1251187
- The paper
- Cohen, E. L., & Wurtman, R. J. (1976). Brain Acetylcholine: Control by Dietary Choline. Science. https://doi.org/10.1126/science.1251187
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
