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Cited by 235

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Presynaptic Nicotinic Cholinergic Receptors Labeled by [3H]Acetylcholine on Catecholamine and Serotonin Axons in Brain

Schwartz, Rochelle D., Lehmann, John, Kellar, Kenneth J.·1984·Journal of Neurochemistry

Abstract

Abstract: Nicotinic cholinergic receptor binding sites labeled by [3 H]acetylcholine were measured in the cerebral cortices, thalami, striata, and hypothalami of rats lesioned by intraventricular injection of either 6‐hydroxydopamine or 5,7‐dihydroxytryptamine. In addition, [3 H]acetylcholine binding sites were measured in the cerebral cortices of rats lesioned by injection of ibotenic acid into the nucleus basalis magnocellularis. [3 H]Acetylcholine binding was significantly decreased in the striata and hypothalami of both 6‐hydroxydopamine‐and 5,7‐dihydroxytryptamine‐lesioned rats. There was no change in binding in the cortex or thalamus by either lesion. Ibotenic acid lesions of the nucleus basalis magnocellularis, which projects cholinergic axons to the cortex, did not alter [3 H]acetylcholine binding. These results provide evidence for a presynaptic location of nicotinic cholinergic binding sites on catecholamine and serotonin axons in the striatum and hypothalamus.

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Metadata

Authors
Schwartz, R. D., Lehmann, J., & Kellar, K. J.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
1984-05
Volume
42
Issue
5
Pages
1495-1498
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
OpenAlex
W2156810782
Cited by
235
References
0
FWCI
4.59
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Presynaptic Nicotinic Cholinergic Receptors Labeled by [3H]Acetylcholine on Catecholamine and Serotonin Axons in Brain. https://app.cochat.ai/papers/10.1111/j.1471-4159.1984.tb02818.x
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Schwartz, R. D., Lehmann, J., & Kellar, K. J. (1984). Presynaptic Nicotinic Cholinergic Receptors Labeled by [3H]Acetylcholine on Catecholamine and Serotonin Axons in Brain. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1984.tb02818.x

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