Cited by 530Neuroscience and Neuropharmacology ResearchNeurological disorders and treatmentsNeural dynamics and brain function

Physiology and pharmacology of striatal neurons

Kreitzer, Anatol C.·2009·Annual Review of Neuroscience

Abstract

The basal ganglia occupy the core of the forebrain and consist of evolutionarily conserved motor nuclei that form recurrent circuits critical for motivation and motor planning. The striatum is the main input nucleus of the basal ganglia and a key neural substrate for procedural learning and memory. The vast majority of striatal neurons are spiny GABAergic projection neurons, which exhibit slow but temporally precise spiking in vivo. Contributing to this precision are several different types of interneurons that constitute only a small fraction of total neuron number but play a critical role in regulating striatal output. This review examines the cellular physiology and modulation of striatal neurons that give rise to their unique properties and function.

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Crossref · 10.1146/annurev.neuro.051508.135422

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182 of 182 references verified0 citation errors · 0 not checkable

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  • The interaction between glutamate and striatal activity serves as an important modulator of synaptic plasticity and neural excitability.

    “It is believed that the interaction between glutamate and striatal activity serves as an important modulator of synaptic plasticity and neural excitability (Surmeier et al., 2007; Kreitzer et al., 2009; Lovinger et al., 2010; Gleich et al., 2015).”

    From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Kreitzer et al., 2009

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Authors
Kreitzer, A. C.
Affiliations
University of California, San Francisco (US)
Corresponding author
Kreitzer, Anatol C.
Venue
Annual Review of Neuroscience
Published
2009-06-01
Volume
32
Issue
1
Pages
127-147
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
OpenAlex
W2110925924
Cited by
530
References
183
Citations by year
2026: 15 · 2025: 18 · 2024: 33 · 2023: 47 · 2022: 31 · 2021: 33 · 2020: 41 · 2019: 36 · 2018: 31 · 2017: 42 · 2016: 28 · 2015: 33 · 2014: 36 · 2013: 25 · 2012: 29
FWCI
2.28
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
Pew Charitable Trusts
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
striatum, basal ganglia, striatal neurons, medium spiny neurons, striatal interneurons, neuronal physiology, pharmacology, GABAergic neurons, striatal output, procedural learning, motor control, recurrent circuits
MeSH terms
Action Potentials, Animals, Basal Ganglia Diseases, Corpus Striatum, Humans, Interneurons, Neural Pathways, Neurons, Neuropeptides, Neurotransmitter Agents, Neuropil

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