The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
An In Vivo Model for Studying Function of Brain Tissue Temporarily Devoid of Glial Cell Metabolism: The Use of Fluorocitrate
Abstract
Abstract: The effect of intrastriatal injection of fluorocitrate on amino acid pattern, cell enzyme markers, and ultrastruc‐tural appearance was investigated. A dose of 1 nmol of fluorocitrate resulted in temporarily decreased levels of glutamine, glutamate, and aspartate, whereas the level of alanine was increased. The glutamine level was severely reduced after 4 h but was reversed after 24 h. The activity of different cellular enzyme markers did not change markedly after this dose. Ultrastructural changes in glial cells were observed, concomitant with the biochemical changes. A dose of ≥2 nmol of fluorocitrate resulted in more marked and irreversible changes in amino acid levels. By 24–72 h after the injection of this dose, several marker enzyme activities decreased markedly. The ultrastructural changes affected the neurons as well as the glial cells and were not reversible. The use of microinjection of 1 nmol of fluorocitrate into the neostria‐tum of the rat to provide a model for studying transmitter amino acid metabolism in brain devoid of glial cell activity is discussed.
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Self-citationGlutamate: A Neurotransmitter in Mammalian Brain
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The involvement of glial cells in the development of morphine tolerance
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Agarwal, A., Wu, P.-H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D., & Bergles, D. E. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.034 · Cited by 441
Ottersen, O. P., Zhang, N., & Walberg, F. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90141-n · Cited by 332
Supraspinal Glial–Neuronal Interactions Contribute to Descending Pain Facilitation
Wei, F., Guo, W., Zou, S., Ren, K., & Dubner, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3593-08.2008 · Cited by 321
Ammonia toxicity: from head to toe?
Dasarathy, S., Mookerjee, R. P., Rackayova, V., Rangroo Thrane, V., Vairappan, B., Ott, P., & Rose, C. F. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9938-3 · Cited by 288
Metadata
- Authors
- Paulsen, R. E., Contestabile, A., Villani, L., & Fonnum, F.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1987-05
- Volume
- 48
- Issue
- 5
- Pages
- 1377-1385
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2113221031
- Cited by
- 262
- References
- 19
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Paulsen, R. E., Contestabile, A., Villani, L., & Fonnum, F. (1987). An In Vivo Model for Studying Function of Brain Tissue Temporarily Devoid of Glial Cell Metabolism: The Use of Fluorocitrate. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1987.tb05674.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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