The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Drug Transfer Across the Blood‐Brain Barrier: Correlation Between In Vitro and In Vivo Models
Abstract
Abstract: To assess the drug transport across the blood‐brain barrier (BBB), we compared the maximal brain extraction values at time 0 [E(0) values] obtained using either in vitro or in vivo methods. The in vitro BBB model consisted of a coculture of brain capillary endothelial cells growing on one side of a filter and astrocytes on the other. The in vivo model used intracarotid injection in anesthetized rats. Eleven compounds were tested. They were selected because they exhibit quantitatively different brain extraction rates: very low for inulin and sucrose, low for oxicam‐related nonsteroidal antiinflammatory drugs and diclofenac, and high for propranolol and diazepam. As these compounds are apparently transferred by a passive diffusion mechanism, two others, glucose and leucine, were added that cross the BBB by a known carrier‐mediated process. The in vivo and in vitro E(0) values showed a strong correlation as indicated by the Spearman's correlation coefficient (r= 0.88, p < 0.01). The relative ease with which such cocultures can be produced in large quantities could facilitate the screening of new centrally acting drugs.
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Cites
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Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard
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An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro
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Self-citationDevelopment of the blood-brain barrier
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Kreuter, J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00122-8 · Cited by 1,107
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Self-citationTranscytosis: Crossing Cellular Barriers
TUMA, P. L., & HUBBARD, A. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00001.2003 · Cited by 681
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Interaction between flavonoids and the blood–brain barrier: in vitro studies
Youdim, K. A., Dobbie, M. S., Kuhnle, G., Proteggente, A. R., Abbott, N. J., & Rice‐Evans, C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01652.x · Cited by 578
Metadata
- Authors
- Dehouck, M., Jolliet‐Riant, P., Brée, F., Fruchart, J., Cecchelli, R., & Tillement, J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1992-05
- Volume
- 58
- Issue
- 5
- Pages
- 1790-1797
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2105301861
- Cited by
- 286
- References
- 31
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Drug Transfer Across the Blood‐Brain Barrier: Correlation Between In Vitro and In Vivo Models. https://app.cochat.ai/papers/10.1111/j.1471-4159.1992.tb10055.x
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- Dehouck, M., Jolliet‐Riant, P., Brée, F., Fruchart, J., Cecchelli, R., & Tillement, J. (1992). Drug Transfer Across the Blood‐Brain Barrier: Correlation Between In Vitro and In Vivo Models. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1992.tb10055.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
