The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Stress‐induced activation of the immediate early gene Arc (activity‐regulated cytoskeleton‐associated protein) is restricted to telencephalic areas in the rat brain: relationship to c‐fos mRNA
Open accessAbstract
Arc is an effector immediate early gene whose expression is induced in situations of increased neuronal activity. However, there is no report on the influence of stress on Arc expression. Here, we compared the induction of both c‐fos and Arc mRNAs in the brain of rats exposed to one of three different stressful situations: novel environment, forced swimming and immobilization. An absent or weak c‐fos mRNA signal was observed in control rats, whereas those exposed to one of three stressors showed enhanced c‐fos expression in a wide range of brain areas. Constitutive Arc expression was observed in some areas such as cortex, striatum, hippocampus, reticular thalamic nucleus and cerebellar cortex. In response to stressors, a strong induction of Arc was observed, but the pattern was different from that of c‐fos. For instance, activation of Arc but not c‐fos was observed in the nucleus accumbens after immobilization and in the hippocampus after novel environment. No Arc induction was observed in diencephalic and brainstem areas. The present data show that Arc has a neuroanatomically restricted pattern of induction in the brain after emotional stress. Telencephalic activation suggests that a more intense induction of synaptic plasticity is occurring in this area after exposure to emotional stressors.
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“However, Arc has a much more restricted pattern of expression than Fos in response to stress: Arc appears to be expressed primarily within telencephalic areas116 and is therefore problematic for mapping global network patterns of activation, including hypothalamic and midbrain structures.”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [116]
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Yilmaz, E. (2010)
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Köhler, T. (2006)
Post traumatic stress disorder: Insights from cat hair and catfish
Nalloor, R. (2012)
Development of aggression and impulsivity: Modulation by adolescent social stress?
Coppens, C. M. (2013) · University of Groningen research database (University of Groningen / Centre for Information Technology)
Moon, B., Kang, S., Kim, H.-J., Shin, S. K., 최상현, Lee, M., Kon, K. M., & Shin, K. H. (2008) · Molecular & Cellular Toxicology
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Selected Key Areas for Future Research on the Claustrum
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Metadata
- Authors
- Ons, S., Martí, O., & Armario, A.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Corresponding author
- Armario, Antonio
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 89
- Issue
- 5
- Pages
- 1111-1118
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1978122462
- Cited by
- 110
- References
- 29
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 1 · 2020: 3 · 2019: 7 · 2018: 9 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 8 · 2012: 5
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Arc, activity-regulated cytoskeleton-associated protein, c-fos, immediate early genes, emotional stress, stress-responsive gene expression, telencephalon, hippocampus, nucleus accumbens, novel environment, forced swim test, immobilization, synaptic plasticity, rat brain
- MeSH terms
- Animals, Autoradiography, Brain, Cytoskeletal Proteins, Male, Nerve Tissue Proteins, RNA, Messenger, Stress, Psychological, Telencephalon, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, In Situ Hybridization, Immediate-Early Proteins, Rats
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