Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory
Open accessAbstract
It is widely believed that the brain processes information and stores memories by modifying and stabilizing synaptic connections between neurons. In experimental models of synaptic plasticity, such as long-term potentiation (LTP), the stabilization of changes in synaptic strength requires rapid de novo RNA and protein synthesis. Candidate genes, which could underlie activity-dependent plasticity, have been identified on the basis of their rapid induction in brain neurons. Immediate-early genes (IEGs) are induced in hippocampal neurons by high-frequency electrical stimulation that induces LTP and by behavioral training that results in long-term memory (LTM) formation. Here, we investigated the role of the IEG Arc (also termed Arg3.1) in hippocampal plasticity. Arc protein is known to be enriched in dendrites of hippocampal neurons where it associates with cytoskeletal proteins (Lyford et al., 1995). Arc is also notable in that its mRNA and protein accumulate in dendrites at sites of recent synaptic activity (Steward et al., 1998). We used intrahippocampal infusions of antisense oligodeoxynucleotides to inhibit Arc protein expression and examined the effect of this treatment on both LTP and spatial learning. Our studies show that disruption of Arc protein expression impairs the maintenance phase of LTP without affecting its induction and impairs consolidation of LTM for spatial water task training without affecting task acquisition or short-term memory. Thus, Arc appears to play a fundamental role in the stabilization of activity-dependent hippocampal plasticity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Arc blockade impairs LTP maintenance and hippocampal-dependent spatial learning.
“Arc blockade impairs long term potentiation (LTP) maintenance and hippocampal-dependent spatial learning15.”
From Early developmental bisphenol-A exposure sex-independently impairs spatial memory by remodeling hippocampal dendritic architecture and synaptic transmission in rats (2016) · cites this paper as [15]
The paper reports that inhibiting Arc protein expression impaired LTP maintenance and long-term memory consolidation for a spatial water task. It explicitly says task acquisition was unaffected, so describing the effect as impaired spatial learning overstates the finding. (LLM, conf=0.89)
Experimental — accuracy not yet measuredGlobal or local deletion of Arc in the hippocampus impairs spatial learning consolidation.
“global or local deletion of Arc in the hippocampus has been demonstrated to impair the spatial learning consolidation3940.”
From Early developmental bisphenol-A exposure sex-independently impairs spatial memory by remodeling hippocampal dendritic architecture and synaptic transmission in rats (2016) · cites this paper as [40]
The section on intrahippocampal Arc antisense infusions and the Discussion report impaired consolidation of spatial water-task memory in rats after local inhibition of Arc expression. The paper does not demonstrate global Arc deletion, and its local intervention was antisense-mediated inhibition rather than deletion. Page numbers are unavailable in our copy. (LLM, conf=0.89)
Experimental — accuracy not yet measuredSynaptically controlled transient expression of Arc is essential for LTP and memory formation.
“Synaptically controlled transient expression of Arc is essential for LTP and memory formation (Guzowski et al., 2000; Kelly and Deadwyler, 2003).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Guzowski et al., 2000
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
Greenberg, M., & Ziff, E. (1984) · Nature · doi:10.1038/311433a0 · Cited by 2,650 · see citing works
Control of memory formation through regulated expression of a CaMKII transgene
Mayford, M., Bach, M. E., Huang, Y.-Y., Wang, L., Hawkins, R. D., & Kandel, E. R. (1996) · Science · doi:10.1126/science.274.5293.1678 · Cited by 1,550 · see citing works
Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain
Tsien, J. Z., Chen, D. F., Gerber, D., Tom, C., Mercer, E. H., Anderson, D. J., Mayford, M., Kandel, E. R., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81826-7 · Cited by 1,280 · see citing works
Lyford, G. L., Yamagata, K., Kaufmann, W. E., Barnes, C. A., Sanders, L. K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Lanahan, A. A., & Worley, P. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90299-6 · Cited by 1,212 · see citing works
Self-citationEnvironment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles
Guzowski, J. F., McNaughton, B. L., Barnes, C. A., & Worley, P. F. (1999) · Nature Neuroscience · doi:10.1038/16046 · Cited by 1,035 · see citing works
Self-citationCole, A. J., Saffen, D. W., Baraban, J. M., & Worley, P. F. (1989) · Nature · doi:10.1038/340474a0 · Cited by 1,010 · see citing works
Self-citationLau, L. F., & Nathans, D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1182 · Cited by 856 · see citing works
Steward, O., Wallace, C. S., Lyford, G. L., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80591-7 · Cited by 811 · see citing works
Self-citationSomatodendritic expression of an immediate early gene is regulated by synaptic activity.
Link, W., Konietzko, U., Kauselmann, G., Krug, M., Schwanke, B., Frey, U., & Kuhl, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5734 · Cited by 706 · see citing works
Curran, T., Peters, G., Beveren, C. V., Teich, N. M., & Verma, I. M. (1982) · Journal of Virology · doi:10.1128/jvi.44.2.674-682.1982 · Cited by 639 · see citing works
Modulation of Anxiety and Neuropeptide Y-Y1 Receptors by Antisense Oligodeoxynucleotides
Wahlestedt, C., Pich, E. M., Koob, G. F., Yee, F., & Heilig, M. A. (1993) · Science · doi:10.1126/science.8380941 · Cited by 524 · see citing works
Guzowski, J. F., & McGaugh, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2693 · Cited by 481 · see citing works
Self-citationSynaptic clustering of AMPA receptors by the extracellular immediate-early gene product narp.
O’Brien, R. J., Xu, D., Petralia, R. S., Steward, O., Huganir, R. L., & Worley, P. (1999) · Neuron · doi:10.1016/s0896-6273(00)80782-5 · Cited by 471 · see citing works
Self-citationConvulsant-induced increase in transcription factor messenger RNAs in rat brain.
Saffen, D. W., Cole, A. J., Worley, P. F., et al. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.20.7795 · Cited by 378 · see citing works
Self-citationA Complex Program of Striatal Gene Expression Induced by Dopaminergic Stimulation
Berke, J. D., Paletzki, R. F., Aronson, G. J., Hyman, S. E., & Gerfen, C. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05301.1998 · Cited by 355 · see citing works
Amphetamine regulates gene expression in rat striatum via transcription factor CREB
Konradi, C. L., Cole, R., Heckers, S., & Hyman, S. E. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05623.1994 · Cited by 349 · see citing works
Worley, P. F., Bhat, R., Baraban, J. M., Erickson, C. A., McNaughton, B. L., & Barnes, C. A. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-11-04776.1993 · Cited by 346 · see citing works
Self-citationImmediate-Early Genes and Synaptic Function
Lanahan, A. A., & Worley, P. F. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3836 · Cited by 344 · see citing works
Self-citationTsui, C., Copeland, N., Gilbert, D., Jenkins, N., Barnes, C., & Worley, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02463.1996 · Cited by 315 · see citing works
Self-citationAssociation Between Brain Temperature and Dentate Field Potentials in Exploring and Swimming Rats
Moser, E. I., Mathiesen, I., & Andersen, P. N. (1993) · Science · doi:10.1126/science.8446900 · Cited by 272 · see citing works
Antisense oligonucleotide strategies in neuropharmacology
Wahlestedt, C. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90107-4 · Cited by 267 · see citing works
Oligodeoxynucleotides as Antisense Inhibitors of Gene Expression
Ghosh, M. K., & Cohen, J. S. (1992) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60574-7 · Cited by 233 · see citing works
LTP saturation and spatial learning disruption: effects of task variables and saturation levels
Barnes, C. A., Jung, M., McNaughton, B. L., Korol, D., Andreasson, K. I., & Worley, P. F. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-05793.1994 · Cited by 219 · see citing works
Self-citationGrowth-related changes in specific mRNAs of cultured mouse cells.
Linzer, D. I. H., & Nathans, D. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.14.4271 · Cited by 209 · see citing works
Dragunow, M., Abraham, W. C., Goulding, M., Mason, S. E., Robertson, H. A., & Faull, R. L. M. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90545-4 · Cited by 185 · see citing works
Wallace, C. S., Lyford, G. L., Worley, P. F., & Steward, O. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00026.1998 · Cited by 171 · see citing works
Self-citationNeuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system
Schlimgen, A. K., Helms, J. A., Vogel, H. S., & Perin, M. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90308-9 · Cited by 163 · see citing works
Widnell, K. L., Self, D. W., Lane, S. B., Russell, D., Vaidya, V. A., Miserendino, M. J. D., Rubin, C. S., Duman, R. S., & Nestler, E. J. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12267-2 · Cited by 156 · see citing works
Activation of arc, a Putative “Effector” Immediate Early Gene, by Cocaine in Rat Brain
Fosnaugh, J. S., Bhat, R. V., Yamagata, K., Worley, P. F., & Baraban, J. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052377.x · Cited by 131 · see citing works
Self-citationUnusual Early Cretaceous birds from Spain
Sanz, J. L., Bonapartet, J. F., & Lacasa, A. (1988) · Nature · doi:10.1038/331433a0 · Cited by 91 · see citing works
Hooper, M. L., Chiasson, B. J., & Robertson, H. A. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90559-2 · Cited by 90 · see citing works
Szklarczyk, A., & Kaczmarek, L. (1995) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00010-r · Cited by 62 · see citing works
Cellular uptake of intracerebrally administered oligodeoxynucleotides in mouse brain
Ogawa, S., Brown, H. E., Okano, H. J., et al. (1995) · Regulatory Peptides · doi:10.1016/0167-0115(95)00096-t · Cited by 55 · see citing works
Hebb, M. O., & Robertson, H. A. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00048-x · Cited by 49 · see citing works
Application of antisense DNA method for the study of molecular bases of brain function and behavior
Ogawa, S., & Pfaff, D. W. (1996) · Behavior Genetics · doi:10.1007/bf02359384 · Cited by 38 · see citing works
Abraham, W. C., Logan, B. J., Thompson, V. L., et al. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00013-0 · Cited by 18 · see citing works
Seizure-inducible c-fos protein(s) in mammalian neurons
Dragunow, M., & Robertson, H. A. (1988) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(88)90229-5 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529 · see citing works
Stress, memory and the amygdala
Roozendaal, B., McEwen, B. S., & Chattarji, S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2651 · Cited by 1,760 · see citing works
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653 · see citing works
MAPK cascade signalling and synaptic plasticity
Thomas, G. M., & Huganir, R. L. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1346 · Cited by 1,454 · see citing works
Molecular mechanisms of fear learning and memory
Johansen, J. P., Cain, C. K., Ostroff, L. E., & LeDoux, J. E. (2011) · Cell · doi:10.1016/j.cell.2011.10.009 · Cited by 1,012 · see citing works
Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers
Lacor, P. N., Buniel, M. C., Chang, L., Fernandez, S. J., Gong, Y., Viola, K. L., Lambert, M. P., Velasco, P. T., Bigio, E. H., Finch, C. E., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-04.2004 · Cited by 954 · see citing works
Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827 · see citing works
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792 · see citing works
Self-citationIndependent cellular processes for hippocampal memory consolidation and reconsolidation
Lee, J. L. C., Everitt, B. J., & Thomas, K. L. (2004) · Science · doi:10.1126/science.1095760 · Cited by 825 · see citing works
Ying, S.-W., Futter, M., Rosenblum, K., Webber, M. J., Hunt, S. P., Bliss, T. V. P., & Bramham, C. R. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01532.2002 · Cited by 784 · see citing works
Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.034 · Cited by 779 · see citing works
Self-citationSchema-dependent gene activation and memory encoding in neocortex
Tse, D., Takeuchi, T., Kakeyama, M., Kajii, Y., Okuno, H., Tohyama, C., Bito, H., & Morris, R. G. M. (2011) · Science · doi:10.1126/science.1205274 · Cited by 618 · see citing works
Bekinschtein, P., Cammarota, M., Igaz, L. M., Bevilaqua, L. R. M., Izquierdo, I., & Medina, J. H. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.025 · Cited by 633 · see citing works
Blalock, E. M., Chen, K.-C., Sharrow, K., Herman, J. P., Porter, N. M., Foster, T. C., & Landfield, P. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03807.2003 · Cited by 570 · see citing works
Measurement of Immediate‐Early Gene Activation‐ <i>c‐fos</i> and Beyond
Kovács, K. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01734.x · Cited by 493 · see citing works
Waung, M. W., Pfeiffer, B. E., Nosyreva, E. D., Ronesi, J. A., & Huber, K. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.014 · Cited by 474 · see citing works
Bramham, C. R., Alme, M. N., Bittins, M., Kuipers, S. D., Nair, R. R., Pai, B., Panja, D., Schubert, M., Soule, J., Tiron, A., et al. (2010) · Experimental Brain Research · doi:10.1007/s00221-009-1959-2 · Cited by 452 · see citing works
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442 · see citing works
Roozendaal, B., & McGaugh, J. L. (2011) · Behavioral Neuroscience · doi:10.1037/a0026187 · Cited by 445 · see citing works
Self-citationNeural and cellular mechanisms of fear and extinction memory formation
Orsini, C. A., & Maren, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.014 · Cited by 429 · see citing works
Arc in synaptic plasticity: from gene to behavior
Korb, E., & Finkbeiner, S. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.08.007 · Cited by 388 · see citing works
Cirelli, C., & Tononi, G. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09187.2000 · Cited by 369 · see citing works
BDNF mechanisms in late LTP formation: A synthesis and breakdown
Panja, D., & Bramham, C. R. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.024 · Cited by 336 · see citing works
Adult‐born hippocampal neurons promote cognitive flexibility in mice
Burghardt, N. S., Park, E. H., Hen, R., & Fenton, A. A. (2012) · Hippocampus · doi:10.1002/hipo.22013 · Cited by 311 · see citing works
Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ
Okuno, H., Akashi, K., Ishii, Y., Yagishita-Kyo, N., Suzuki, K., Nonaka, M., Kawashima, T., Fujii, H., Takemoto-Kimura, S., Abe, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.062 · Cited by 310 · see citing works
Self-citationChin, J., Palop, J. J., Puoliväli, J., Massaro, C., Bien-Ly, N., Gerstein, H., Scearce-Levie, K., Masliah, E., & Mucke, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2980-05.2005 · Cited by 312 · see citing works
Local protein synthesis, actin dynamics, and LTP consolidation
Bramham, C. R. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.09.013 · Cited by 301 · see citing works
BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission
Waterhouse, E. G., An, J. J., Orefice, L. L., Baydyuk, M., Liao, G.-Y., Zheng, K., Lu, B., & Xu, B. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0709-12.2012 · Cited by 287 · see citing works
McGaugh, J. L. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-014954 · Cited by 271 · see citing works
Self-citationUnger, M. S., Li, E., Scharnagl, L., Poupardin, R., Altendorfer, B., Mrowetz, H., Hutter-Paier, B., Weiger, T. M., Heneka, M. T., Attems, J., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.05.070 · Cited by 248 · see citing works
Dickey, C. A., Loring, J. F., Montgomery, J., Gordon, M. N., Eastman, P. S., & Morgan, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05219.2003 · Cited by 242 · see citing works
Biochemical Computation for Spine Structural Plasticity
Nishiyama, J., & Yasuda, R. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.043 · Cited by 199 · see citing works
Bredy, T. W., Zhang, T. Y., Grant, R. J., Diorio, J., & Meaney, M. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03599.x · Cited by 196 · see citing works
Chin, J., Massaro, C. M., Palop, J. J., Thwin, M. T., Yu, G.-Q., Bien-Ly, N., Bender, A., & Mucke, L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3758-06.2007 · Cited by 188 · see citing works
Nichols, C. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00405-5 · Cited by 163 · see citing works
The Role of Extracellular Regulated Kinases I/II in Late-Phase Long-Term Potentiation
Rosenblum, K., Futter, M., Voss, K., Erent, M., Skehel, P. A., French, P., Obosi, L., Jones, M. W., & Bliss, T. V. P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05432.2002 · Cited by 155 · see citing works
Niere, F., Wilkerson, J. R., & Huber, K. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4650-11.2012 · Cited by 153 · see citing works
Role of the Basolateral Amygdala in Memory Consolidation
McINTYRE, C. K., POWER, A. E., ROOZENDAAL, B., & McGAUGH, J. L. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07088.x · Cited by 147 · see citing works
Self-citationOrtiz, O., Delgado-García, J. M., Espadas, I., Bahí, A., Trullas, R., Dreyer, J.-L., Gruart, A., & Moratalla, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2655-10.2010 · Cited by 143 · see citing works
Low BDNF is associated with cognitive deficits in patients with type 2 diabetes
Zhen, Y. F., Zhang, J., Liu, X. Y., Fang, H., Tian, L. B., Zhou, D. H., Kosten, T. R., & Zhang, X. Y. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2942-3 · Cited by 126 · see citing works
Ons, S., Martí, O., & Armario, A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02396.x · Cited by 110 · see citing works
Neuroimmune regulation of homeostatic synaptic plasticity
Pribiag, H., & Stellwagen, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.008 · Cited by 106 · see citing works
NF-κB/Rel Regulates Inhibitory and Excitatory Neuronal Function and Synaptic Plasticity
O'Mahony, A., Raber, J., Montano, M., Foehr, E., Han, V., Lu, S.-M., Kwon, H., LeFevour, A., Chakraborty-Sett, S., & Greene, W. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00510-06 · Cited by 110 · see citing works
Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease
Rudinskiy, N., Hawkes, J. M., Betensky, R. A., Eguchi, M., Yamaguchi, S., Spires-Jones, T. L., & Hyman, B. T. (2012) · Nature Neuroscience · doi:10.1038/nn.3199 · Cited by 103 · see citing works
Locus Ceruleus Control of State-Dependent Gene Expression
Cirelli, C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0949-04.2004 · Cited by 103 · see citing works
Schochet, T. L., Kelley, A. E., & Landry, C. F. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.057 · Cited by 93 · see citing works
Fox, L. M., William, C. M., Adamowicz, D. H., Pitstick, R., Carlson, G. A., Spires-Jones, T. L., & Hyman, B. T. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318220a658 · Cited by 88 · see citing works
Kuipers, S. D., Trentani, A., Tiron, A., Mao, X., Kuhl, D., & Bramham, C. R. (2016) · Scientific Reports · doi:10.1038/srep21222 · Cited by 83 · see citing works
Synapse development organized by neuronal activity-regulated immediate-early genes
Kim, S., Kim, H., & Um, J. W. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-018-0025-1 · Cited by 77 · see citing works
Bramham, C. R. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)63025-8 · Cited by 69 · see citing works
Smolen, P., Baxter, D. A., & Byrne, J. H. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.072470 · Cited by 61 · see citing works
Karabeg, M. M., Grauthoff, S., Kollert, S. Y., Weidner, M., Heiming, R. S., Jansen, F., Popp, S., Kaiser, S., Lesch, K.-P., Sachser, N., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078238 · Cited by 56 · see citing works
Teber, I., Köhling, R., Speckmann, E.-J., Barnekow, A., & Kremerskothen, J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.11.017 · Cited by 53 · see citing works
Liu, Z.-H., Ding, J.-J., Yang, Q.-Q., Song, H.-Z., Chen, X.-T., Xu, Y., Xiao, G.-R., & Wang, H.-L. (2016) · Scientific Reports · doi:10.1038/srep32492 · Cited by 53 · see citing works
Cao, G., & Harris, K. M. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00297.2014 · Cited by 41 · see citing works
Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses
Rudinskiy, N., Hawkes, J. M., Wegmann, S., Kuchibhotla, K. V., Muzikansky, A., Betensky, R. A., Spires-Jones, T. L., & Hyman, B. T. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-63 · Cited by 32 · see citing works
Jones, N. S., Watson, K. Q., & Rebeck, G. W. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02256-2 · Cited by 26 · see citing works
Schochet, T. L., Bremer, Q. Z., Brownfield, M. S., Kelley, A. E., & Landry, C. F. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06483.x · Cited by 14 · see citing works
- Authors
- Guzowski, J. F., Lyford, G. L., Stevenson, G. D., Houston, F. P., McGaugh, J. L., Worley, P. F., & Barnes, C. A.
- Affiliations
- University of California, Irvine (US)
- Johns Hopkins University (US)
- University of Arizona (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-06-01
- Volume
- 20
- Issue
- 11
- Pages
- 3993-4001
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6772617
- OpenAlex
- W2167423431
- Cited by
- 992
- References
- 38
- Citations by year
- 2026: 4 · 2025: 18 · 2024: 27 · 2023: 16 · 2022: 31 · 2021: 36 · 2020: 33 · 2019: 30 · 2018: 34 · 2017: 58 · 2016: 42 · 2015: 49 · 2014: 62 · 2013: 62 · 2012: 65
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh001227-04)
- National Institute on Aging (AG09219, R01AG009219)
- National Institute of Mental Health (K02MH001152, MH-01227, MH 53603, R01MH012526, R56MH012526)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Arc protein, immediate early genes, long-term potentiation, long-term memory consolidation, hippocampus, synaptic plasticity, spatial learning, antisense oligodeoxynucleotides, dendrites, RNA and protein synthesis, short-term memory
- MeSH terms
- Animals, Behavior, Animal, Cytoskeletal Proteins, Electrophysiology, Gene Expression Regulation, Hippocampus, Male, Memory, Nerve Tissue Proteins, Neuronal Plasticity, Rats, Inbred F344, Synapses, Blotting, Western, Long-Term Potentiation, Maze Learning, Oligodeoxyribonucleotides, Antisense, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
