Cited by 110Stress Responses and CortisolNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

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Stress‐induced activation of the immediate early gene Arc (activity‐regulated cytoskeleton‐associated protein) is restricted to telencephalic areas in the rat brain: relationship to c‐fos mRNA

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Ons, Sheila, Martí, Octavi, Armario, Antonio·2004·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2004.02396.x

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Abstract

Arc is an effector immediate early gene whose expression is induced in situations of increased neuronal activity. However, there is no report on the influence of stress on Arc expression. Here, we compared the induction of both c‐fos and Arc mRNAs in the brain of rats exposed to one of three different stressful situations: novel environment, forced swimming and immobilization. An absent or weak c‐fos mRNA signal was observed in control rats, whereas those exposed to one of three stressors showed enhanced c‐fos expression in a wide range of brain areas. Constitutive Arc expression was observed in some areas such as cortex, striatum, hippocampus, reticular thalamic nucleus and cerebellar cortex. In response to stressors, a strong induction of Arc was observed, but the pattern was different from that of c‐fos. For instance, activation of Arc but not c‐fos was observed in the nucleus accumbens after immobilization and in the hippocampus after novel environment. No Arc induction was observed in diencephalic and brainstem areas. The present data show that Arc has a neuroanatomically restricted pattern of induction in the brain after emotional stress. Telencephalic activation suggests that a more intense induction of synaptic plasticity is occurring in this area after exposure to emotional stressors.

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Authors: Ons, S., Martí, O., & Armario, A.
Affiliations: Universitat Autònoma de Barcelona (ES)
Corresponding author: Armario, Antonio
ORCID: Ons, Sheila
Armario, Antonio
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2004-04-29
Volume: 89
Issue: 5
Pages: 1111-1118
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2004.02396.x
OpenAlex: W1978122462
Cited by: 110
References: 29
Citations by year: 2025: 3 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 1 · 2020: 3 · 2019: 7 · 2018: 9 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 8 · 2012: 5
FWCI: 2.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: Arc, activity-regulated cytoskeleton-associated protein, c-fos, immediate early genes, emotional stress, stress-responsive gene expression, telencephalon, hippocampus, nucleus accumbens, novel environment, forced swim test, immobilization, synaptic plasticity, rat brain
MeSH terms: Animals, Autoradiography, Brain, Cytoskeletal Proteins, Male, Nerve Tissue Proteins, RNA, Messenger, Stress, Psychological, Telencephalon, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, In Situ Hybridization, Immediate-Early Proteins, Rats

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Stress‐induced activation of the immediate early gene Arc (activity‐regulated cytoskeleton‐associated protein) is restricted to telencephalic areas in the rat brain: relationship to c‐fos mRNA

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