The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Overexpression of α‐synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α‐synuclein and activation of caspase‐9: resemblance to pathogenetic changes in Parkinson's disease
Abstract
To elucidate the role of α‐synuclein in the pathogenesis of Parkinson's disease, both human α‐synuclein transgenic mice and targeted overexpression of human α‐synuclein in rat substantia nigra using viral vector‐based methods have been studied, however, little is known about the pathogenetic changes of dopaminergic neuron loss. Therefore, it is necessary to address whether the pathogenetic changes in brains with Parkinson's disease are recapitulated in these models. Here, we used the recombinant adeno‐associated viral (rAAV) vector system for human α‐synuclein gene transfer to rat substantia nigra and observed approximately 50% loss of dopaminergic neurons at 13 weeks after infection, which was comparably slower than the progression of neurodegeneration reported in other studies. In the slower progression of neurodegeneration, we identified several important features in common with the pathogenesis of Parkinson's disease, such as phosphorylation of α‐synuclein at Ser129 and activation of caspase‐9. Both findings were also evident in cortical tissues overexpressing α‐synuclein via rAAV. Our results indicate that overexpression of α‐synuclein via rAAV apparently recapitulates several important features of brains with Parkinson's disease and dementia with Lewy bodies, and thus α‐synucleinopathy described here is likely to be an ideal model for the study of the pathogenesis of Parkinson's disease and dementia with Lewy bodies.
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Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions
Hasegawa, M., Fujiwara, H., Nonaka, T., Wakabayashi, K., Takahashi, H., Lee, V. M.-Y., Trojanowski, J. Q., Mann, D., & Iwatsubo, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208046200 · Cited by 428
Self-citationThe rat brain synucleins; family of proteins transiently associated with neuronal membrane
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Behavioral and Neurochemical Effects of Wild-Type and Mutated Human α-Synuclein in Transgenic Mice
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Mahul-Mellier, A.-L., Burtscher, J., Maharjan, N., Weerens, L., Croisier, M., Kuttler, F., Leleu, M., Knott, G. W., & Lashuel, H. A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913904117 · Cited by 710
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Metadata
- Authors
- Yamada, M., Iwatsubo, T., Mizuno, Y., & Mochizuki, H.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2004-09-10
- Volume
- 91
- Issue
- 2
- Pages
- 451-461
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2056675110
- Cited by
- 270
- References
- 6
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yamada, M., Iwatsubo, T., Mizuno, Y., & Mochizuki, H. (2004). Overexpression of α‐synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α‐synuclein and activation of caspase‐9: resemblance to pathogenetic changes in Parkinson's disease. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2004.02728.x
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