The rat brain synucleins; family of proteins transiently associated with neuronal membrane

The rat brain in stereotaxic coordinates

Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

Maroteaux, L., Campanelli, J., & Scheller, R. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02804.1988 · Cited by 1,646 · see citing works

CELL-SURFACE ANCHORING OF PROTEINS VIA GLYCOSYL-PHOSPHATIDYLINOSITOL STRUCTURES

Ferguson, M. A. J., & Williams, A. F. (1988) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.57.070188.001441 · Cited by 1,290 · see citing works

Axonal Growth-Associated Proteins

Skene, J. H. P. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.001015 · Cited by 1,145 · see citing works

Organization and morphological characteristics of cholonergic neurons: an immunocytochemical study with a monoclonal antibody to choline acetyltransferase

Houser, C. R., Crawford, G. D., Barber, R. P., Salvaterra, P. M., & Vaughn, J. E. (1983) · Brain Research · doi:10.1016/0006-8993(83)91312-4 · Cited by 748 · see citing works

Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

Noda, M., Takahashi, H. K., Tanabe, T., Toyosato, M., Furutani, Y., Hirose, T., Asai, M., Inayama, S., Miyata, T., & Numa, S. (1982) · Nature · doi:10.1038/299793a0 · Cited by 735 · see citing works

An autoradiographic study of the organization of intrahippocampal association pathways in the rat

Swanson, L. W., Wyss, J. M., & Cowan, W. M. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901810402 · Cited by 704 · see citing works

Protein Import into the Cell Nucleus

Dingwall, C., & Laskey, R. A. (1986) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.02.110186.002055 · Cited by 536 · see citing works

Localization of a family of muscarinic receptor mRNAs in rat brain

Buckley, N. J., Bonner, T. I., & Brann, M. R. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-12-04646.1988 · Cited by 478 · see citing works

Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system

Goldman, D. J., Deneris, E. S., Luyten, W. H. M. L., Kochhar, A., Patrick, J., & Heinemann, S. (1987) · Cell · doi:10.1016/0092-8674(87)90705-7 · Cited by 388 · see citing works

A Synaptic Vesicle Protein with a Novel Cytoplasmic Domain and Four Transmembrane Regions

Südhof, T. C., Lottspeich, F., Greengard, P., Mehl, E., & Jahn, R. (1987) · Science · doi:10.1126/science.3120313 · Cited by 327 · see citing works

Eukaryotic protein modification and membrane attachment via phosphatidylinositol

Cross, G. (1987) · Cell · doi:10.1016/0092-8674(87)90419-3 · Cited by 302 · see citing works

Primary structure and expression of β2: A novel subunit of neuronal nicotinic acetylcholine receptors

Deneris, E. S., Connolly, J. G., Boulter, J., Wada, E., Wada, K., Swanson, L. W., Patrick, J., & Heinemann, S. (1988) · Neuron · doi:10.1016/0896-6273(88)90208-5 · Cited by 297 · see citing works

Distinct patterns of expression of different protein kinase C mRNAs in rat tissues

Brandt, S. J., Niedel, J. E., Bell, R. M., & Young, W. S. (1987) · Cell · doi:10.1016/0092-8674(87)90755-0 · Cited by 221 · see citing works

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

Lin, C.-J. R., Kapiloff, M., Durgerian, S., Tatemoto, K., Russo, A., Hanson, P., Schulman, H., & Rosenfeld, M. G. (1987) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.84.16.5962 · Cited by 214 · see citing works

Multiple neuropeptides derived from a common precursor are differentially packaged and transported

Fisher, J. M., Sossin, W. S., Newcomb, R., & Scheller, R. H. (1988) · Cell · doi:10.1016/s0092-8674(88)91131-2 · Cited by 197 · see citing works

Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems.

Worley, P. F., Baraban, J. M., Dop, C. V., Neer, E. J., & Snyder, S. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4561 · Cited by 170 · see citing works

Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments

Jackson, A. P., Seow, H. F., Holmes, N. J., Drickamer, K., & Parham, P. (1987) · Nature · doi:10.1038/326154a0 · Cited by 145 · see citing works

Brain phospholipase C isozymes: differential mRNA localizations by in situ hybridization.

Ross, C. A., MacCumber, M. W., Glatt, C. E., & Snyder, S. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2923 · Cited by 131 · see citing works

Mapping of brain areas expressing RNA homologous to two different acetylcholine receptor alpha-subunit cDNAs.

Goldman, D. J., Simmons, D. M., Swanson, L. W., Patrick, J., & Heinemann, S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4076 · Cited by 111 · see citing works

Phosphoprotein F1: purification and characterization of a brain kinase C substrate related to plasticity

Chan, S., Murakami, K., & Routtenberg, A. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-12-03618.1986 · Cited by 100 · see citing works

G protein mRNA mapped in rat brain by in situ hybridization.

Largent, B. L., Jones, D. T., Reed, R. R., Pearson, R. C. A., & Snyder, S. H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2864 · Cited by 87 · see citing works

The structure and mechanism of neurotransmitter receptors. Implications for the structure and function of the central nervous system

Strange, P. G. (1988) · Biochemical Journal · doi:10.1042/bj2490309 · Cited by 75 · see citing works

VAT 1: An abundant membrane protein from torpedo cholinergic synaptic vesicles

Linial, M., Miller, K., & Scheller, R. H. (1989) · Neuron · doi:10.1016/0896-6273(89)90311-5 · Cited by 69 · see citing works

Molecular biology of synaptic vesicle-associated proteins

Trimble, W. S., & Scheller, R. H. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90098-7 · Cited by 60 · see citing works

Protein kinases: A diverse family of related proteins

Taylor, S. S. (1987) · BioEssays · doi:10.1002/bies.950070106 · Cited by 46 · see citing works

Chemical modification of charged amino acid moieties alters the electrophoretic mobilities of neurofilament subunits on SDS/polyacrylamide gels

Georges, E., & Mushynski, W. E. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb11439.x · Cited by 34 · see citing works

A Unique Neurofilament from Torpedo Electric Lobe: Sequence, Expression, and Localization Analysis

Linial, M., & Scheller, R. H. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02316.x · Cited by 13 · see citing works

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)80886-7 · Cited by 1,722 · see citing works

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

Davidson, W. S., Jonas, A., Clayton, D. F., & George, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9443 · Cited by 1,588 · see citing works

-Synuclein in Parkinson's Disease

Stefanis, L. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009399 · Cited by 1,446 · see citing works

The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., Rohan de Silva, H. A., Kittel, A., & Saitoh, T. (1995) · Neuron · doi:10.1016/0896-6273(95)90302-x · Cited by 1,316 · see citing works

Identification of two distinct synucleins from human brain

Jakes, R., Spillantini, M. G., & Goedert, M. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00395-5 · Cited by 1,080 · see citing works

α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration

Chandra, S. S., Gallardo, G., Fernández‐Chacón, R., Schlüter, O. M., & Südhof, T. C. (2005) · Cell · doi:10.1016/j.cell.2005.09.028 · Cited by 967 · see citing works

The function of α-synuclein

Bendor, J. T., Logan, T. P., & Edwards, R. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.004 · Cited by 825 · see citing works

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch

George, J. M., Jin, H., Woods, W. S., & Clayton, D. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90040-3 · Cited by 844 · see citing works

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

Clayton, D. F., & George, J. M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01213-7 · Cited by 779 · see citing works

Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation

Serpell, L. C., Berriman, J. A., Jakes, R., Goedert, M., & Crowther, R. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4897 · Cited by 748 · see citing works

α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress

Hsu, L. J., Sagara, Y., Arroyo, A., Rockenstein, E. M., Sisk, A., Mallory, M. E., Wong, J., Takenouchi, T., Hashimoto, M., & Masliah, E. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64553-1 · Cited by 716 · see citing works

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

Tu, P., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q., & Lee, V. M. ‐. (1998) · Annals of Neurology · doi:10.1002/ana.410440324 · Cited by 686 · see citing works

Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain

Kahle, P. J., Neumann, M., Ozmen, L., Müller, V., Jacobsen, H., Schindzielorz, A., Okochi, M., Leimer, U., van der Putten, H., Probst, A., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06365.2000 · Cited by 641 · see citing works

α-Synuclein Membrane Interactions and Lipid Specificity

Jo, E., McLaurin, J., Yip, C. M., George‐Hyslop, P. S., & Fraser, P. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004345200 · Cited by 602 · see citing works

The Synucleinopathies: Twenty Years On

Goedert, M., Jakes, R., & Spillantini, M. G. (2017) · Journal of Parkinson s Disease · doi:10.3233/jpd-179005 · Cited by 566 · see citing works

A Broken α-Helix in Folded α-Synuclein

Chandra, S. S., Chen, X., Rizo, J., Jahn, R., & Südhof, T. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213128200 · Cited by 540 · see citing works

The α‐Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy

Spillantini, M. G., & Goedert, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06900.x · Cited by 520 · see citing works

Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein

Okochi, M., Walter, J., Koyama, A., Nakajo, S., Baba, M., Iwatsubo, T., Meijer, L., Kahle, P. J., & Haass, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.390 · Cited by 521 · see citing works

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

Lin, X. Z., Parisiadou, L., Gu, X., Wang, L., Shim, H., Sun, L., Xie, C., Long, C.-X., Yang, W.-J., Ding, J., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.006 · Cited by 513 · see citing works

Raman Spectroscopic Characterization of Secondary Structure in Natively Unfolded Proteins: α-Synuclein

Maiti, N. C., Apetri, M. M., Zagorski, M. G., CAREY, P. R., & Anderson, V. E. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0356176 · Cited by 516 · see citing works

Binding of α-Synuclein to Brain Vesicles Is Abolished by Familial Parkinson's Disease Mutation

Jensen, P. H., Nielsen, M. S., Jakes, R., Dotti, C. G., & Goedert, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26292 · Cited by 512 · see citing works

α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis

Mehra, S., Sahay, S., & Maji, S. K. (2019) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2019.03.001 · Cited by 507 · see citing works

Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases

Mandel, S. A., & Youdim, M. B. H. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.012 · Cited by 443 · see citing works

α-Synuclein Overexpression in PC12 and Chromaffin Cells Impairs Catecholamine Release by Interfering with a Late Step in Exocytosis

Larsen, K. E., Schmitz, Y., Troyer, M. D., Mosharov, E. V., Dietrich, P., Quazi, A. Z., Savalle, M., Nemani, V. M., Chaudhry, F. A., Edwards, R. H., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3821-06.2006 · Cited by 415 · see citing works

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.

Takeda, A., Mallory, M. E., Sundsmo, M. P., Honer, W. G., Hansen, L. A., & Masliah, E. (1998) · Europe PMC (PubMed Central) · Cited by 404 · see citing works

α‐Synuclein Up‐Regulation in Substantia Nigra Dopaminergic Neurons Following Administration of the Parkinsonian Toxin MPTP

Vila, M., Vukosavić, S., Jackson-Lewis, V. R., Neystat, M., Jakowec, M. W., & Przedborski, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740721.x · Cited by 388 · see citing works

A critical evaluation of the Braak staging scheme for Parkinson's disease

Burke, R. E., Dauer, W. T., & Vonsattel, J. P. (2008) · Annals of Neurology · doi:10.1002/ana.21541 · Cited by 377 · see citing works

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases

Lackie, R. E., Maciejewski, A., Ostapchenko, V. G., Marques-Lopes, J., Choy, W., Duennwald, M. L., Prado, V. F., & Prado, M. A. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00254 · Cited by 375 · see citing works

α-synuclein in the pathophysiology of Alzheimer’s disease

Twohig, D., & Nielsen, H. M. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0320-x · Cited by 374 · see citing works

Effect of Mutant α-Synuclein on Dopamine Homeostasis in a New Human Mesencephalic Cell Line

Lotharius, J., Barg, S., Wiekop, P., Lundberg, C., Raymon, H. K., & Brundin, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205518200 · Cited by 349 · see citing works

Fate of Midbrain Dopaminergic Neurons Controlled by the Engrailed Genes

Simon, H. H., Saueressig, H., Wurst, W., Goulding, M., & O’Leary, D. D. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03126.2001 · Cited by 347 · see citing works

Copper(II)-induced self-oligomerization of α-synuclein

Paik, S. R., Shin, H.-J., Lee, J., Chang, C., & Kim, J. (1999) · Biochemical Journal · doi:10.1042/bj3400821 · Cited by 332 · see citing works

Structural Organization of α-Synuclein Fibrils Studied by Site-directed Spin Labeling

Der-Sarkissian, A., Jao, C. C., Chen, J., & Langen, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305266200 · Cited by 328 · see citing works

The Synuclein FamilyPreprint

Lavedan, C. N. (1998) · Genome Research · doi:10.1101/gr.8.9.871 · Cited by 321 · see citing works

Lipid Binding Inhibits α-Synuclein Fibril Formation

Zhu, M., & Fink, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210136200 · Cited by 314 · see citing works

The physiological role of α‐synuclein and its relationship to Parkinson’s Disease

Sulzer, D., & Edwards, R. H. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14810 · Cited by 310 · see citing works

Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP111-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Song, D. D., Shults, C. W., Sisk, A., Rockenstein, E. M., & Masliah, E. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00342-x · Cited by 294 · see citing works

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by β-amyloid: is NAC a common trigger or target in neurodegenerative disease?

Han, H., Weinreb, P. H., & Lansbury, P. T. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90071-3 · Cited by 284 · see citing works

Alpha-synuclein and Parkinson's disease

Lücking, C. B., & Brice, A. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000671 · Cited by 279 · see citing works

Neural Activity Controls the Synaptic Accumulation of α-Synuclein

Fortin, D. L., Nemani, V. M., Voglmaier, S. M., Anthony, M. D., Ryan, T. A., & Edwards, R. H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2922-05.2005 · Cited by 262 · see citing works

Overexpression of α‐synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α‐synuclein and activation of caspase‐9: resemblance to pathogenetic changes in Parkinson's disease

YAMADA, M., Iwatsubo, T., Mizuno, Y., & Mochizuki, H. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02728.x · Cited by 270 · see citing works

Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease

Hashimoto, M., Hsu, L. J., Sisk, A., Xia, Y., Takeda, A., Sundsmo, M. P., & Masliah, E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00514-9 · Cited by 267 · see citing works

Alpha‐synuclein in Lewy Body Disease and Alzheimer's Disease

Hashimoto, M., & Masliah, E. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00552.x · Cited by 251 · see citing works

α-Synuclein in synaptic function and dysfunction

Sharma, M., & Burré, J. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.11.007 · Cited by 247 · see citing works

NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

Arima, K., Uéda, K., Sunohara, N., Arakawa, K., Hirai, S., Nakamura, M., Tonozuka-Uehara, H., & Kawai, M. (1998) · Acta Neuropathologica · doi:10.1007/s004010050917 · Cited by 239 · see citing works

Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model

Kahle, P. J., Neumann, M., Ozmen, L., Müller, V., Odoy, S., Okamoto, N., Jacobsen, H., Iwatsubo, T., Trojanowski, J. Q., Takahashi, H., et al. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63072-6 · Cited by 239 · see citing works

Parkinson’s disease: proteinopathy or lipidopathy?

Fanning, S., Selkoe, D. J., & Dettmer, U. (2020) · npj Parkinson s Disease · doi:10.1038/s41531-019-0103-7 · Cited by 238 · see citing works

Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons

Withers, G. S., George, J. M., Banker, G. A., & Clayton, D. F. (1997) · Developmental Brain Research · doi:10.1016/s0165-3806(96)00210-6 · Cited by 235 · see citing works

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson’s disease

Meredith, G. E., Totterdell, S., Petroske, E., Cruz, K. S., Callison, R. C., & Lau, Y.-S. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03514-x · Cited by 212 · see citing works

Brain α-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation

Tong, J., Wong, H., Guttman, M., Ang, L. C., Forno, L. S., Shimadzu, M., Rajput, A. H., Muenter, M. D., Kish, S. J., Hornykiewicz, O., et al. (2009) · Brain · doi:10.1093/brain/awp282 · Cited by 204 · see citing works

α-Synuclein: Normal Function and Role in Neurodegenerative Diseases

Norris, E. H., Giasson, B. I., & Lee, V. M. ‐. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)60002-0 · Cited by 202 · see citing works

α‐Synuclein produces a long‐lasting increase in neurotransmitter release

Liu, S., Ninan, I., Antonova, I., Battaglia, F., Trinchese, F., Narasanna, A., Kolodilov, N., Dauer, W., Hawkins, R. D., & Arancio, O. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600451 · Cited by 198 · see citing works

The role of α-synuclein in neurodegenerative diseases

Bennett, M. C. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.10.010 · Cited by 195 · see citing works

SDS-Induced Fibrillation of α-Synuclein: An Alternative Fibrillation Pathway

Giehm, L., Oliveira, C. L. P., Christiansen, G., Pedersen, J. S., & Otzen, D. E. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.05.060 · Cited by 195 · see citing works

Extensive nuclear localization of α-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody

Yu, S., Li, X., Liu, G., Han, J., Zhang, C., Li, Y., Xu, S., Liu, C., Gao, Y., Yang, H., et al. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.028 · Cited by 192 · see citing works

Alpha synuclein in neurodegenerative disorders: Murderer or accomplice?

Mezey, É., Dehejia, A. M., Harta, G., Papp, M. I., Polymeropoulos, M. H., & Brownstein, M. (1998) · Nature Medicine · doi:10.1038/nm0798-755 · Cited by 185 · see citing works

Genes, proteins, and neurotoxins involved in Parkinson’s disease

Halbach, O. V. B. U., Schober, A., & KRIEGLSTEIN, K. G. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.002 · Cited by 178 · see citing works

Identification, localization and characterization of the human γ-synuclein gene

Lavedan, C. N., Leroy, E., Dehejia, A. M., Buchholtz, S. A., Dutra, A., Nussbaum, R. L., & Polymeropoulos, M. H. (1998) · Human Genetics · doi:10.1007/s004390050792 · Cited by 179 · see citing works

Motor dysfunction and gliosis with preserved dopaminergic markers in human α-synuclein A30P transgenic mice

Gómez‐Isla, T., Irizarry, M. C., Mariash, A., Cheung, B. S., Soto, O., Schrump, S. E., Sondel, J., Kotilinek, L., Day, J., Schwarzschild, M. A., et al. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00091-x · Cited by 179 · see citing works

Iron and α-Synuclein in the Substantia Nigra of MPTP-Treated Mice: Effect of Neuroprotective Drugs R-Apomorphine and Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate

Mandel, S. A., Maor, G., & Youdim, M. B. H. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:3:401 · Cited by 171 · see citing works

Synaptic failure and α‐synuclein

Calò, L., Węgrzynowicz, M., Santivañez‐Perez, J., & Spillantini, M. G. (2016) · Movement Disorders · doi:10.1002/mds.26479 · Cited by 170 · see citing works

Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization

Arendt, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00516-9 · Cited by 168 · see citing works

Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

Oliveira, L. M. A., Gasser, T., Edwards, R. H., Zweckstetter, M., Melki, R., Stefanis, L., Lashuel, H. A., Sulzer, D. L., Vekrellis, K., Halliday, G. M., et al. (2021) · npj Parkinson s Disease · doi:10.1038/s41531-021-00203-9 · Cited by 169 · see citing works

Persyn, a Member of the Synuclein Family, Has a Distinct Pattern of Expression in the Developing Nervous System

Buchman, V. L., Hunter, H. J. A., Piñón, L. G. P., Thompson, J., Privalova, E. M., Ninkina, N. N., & Davies, A. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09335.1998 · Cited by 169 · see citing works

Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease.

Masliah, E., Iwai, A., Mallory, M. E., Uéda, K., & Saitoh, T. (1996) · Europe PMC (PubMed Central) · Cited by 166 · see citing works

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies

Peng, C., Gathagan, R. J., & Lee, V. M. ‐. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.07.018 · Cited by 164 · see citing works

α-Synuclein–induced Aggregation of Cytoplasmic Vesicles inSaccharomyces cerevisiae

Soper, J. H., Roy, S., Stieber, A., Lee, E., Wilson, R. B., Trojanowski, J. Q., Burd, C. G., & Lee, V. M. ‐. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-08-0827 · Cited by 157 · see citing works

Is Parkinson's disease a primary olfactory disorder?

Hawkes, C. H. (1999) · QJM · doi:10.1093/qjmed/92.8.473 · Cited by 152 · see citing works

Ubiquinone (Coenzyme Q10) and Mitochondria in Oxidative Stress of Parkinson’s Disease

Ebadi, M., Govitrapong, P., Sharma, S., Muralikrishnan, D., Shavali, S., Pellett, L. J., Schafer, R., Albano, C. B., & Eken, J. (2001) · Neurosignals · doi:10.1159/000046889 · Cited by 150 · see citing works

Demonstration of α-Synuclein Immunoreactivity in Neuronal and Glial Cytoplasm in Normal Human Brain Tissue Using Proteinase K and Formic Acid Pretreatment

Mori, F., Tanji, K., Yoshimoto, M., Takahashi, H., & Wakabayashi, K. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7929 · Cited by 149 · see citing works

Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease

Killiany, R., Gómez‐Isla, T., Moss, M. B., Kikinis, R., Sándor, T., Jolesz, F. A., Tanzi, R. E., Jones, K. J., Hyman, B. T., & Albert, M. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200004)47:4 · Cited by 659 · see citing works

Aluminum-Induced Structural Alterations of the Precursor of the Non-Aβ Component of Alzheimer's Disease Amyloid

Paik, S. R., Lee, J., Kim, D.-H., Chang, C., & Kim, J. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0207 · Cited by 148 · see citing works

Presynaptic Alpha-Synuclein Aggregation in a Mouse Model of Parkinson's Disease

Spinelli, K. J., Taylor, J. K., Osterberg, V. R., Churchill, M. J., Pollock, E., Moore, C., Meshul, C. K., & Unni, V. K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2581-13.2014 · Cited by 144 · see citing works

Differential localization of α-, β- and γ-synucleins in the rat CNS

Li, J.-Y., Jensen, P. H., & Dahlström, A. B. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00143-4 · Cited by 141 · see citing works

Structural insights on physiological functions and pathological effects of ±‐synuclein

Bisaglia, M., Mammi, S., & Bubacco, L. (2008) · The FASEB Journal · doi:10.1096/fj.08-119784 · Cited by 140 · see citing works

α-Synuclein Interacts with Phospholipase D Isozymes and Inhibits Pervanadate-induced Phospholipase D Activation in Human Embryonic Kidney-293 Cells

Ahn, B., Rhim, H., Kim, S. Y., Sung, Y., Lee, M., Choi, J., Wolozin, B. L., Chang, J., Lee, Y. H., Kwon, T. K., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110414200 · Cited by 136 · see citing works

Activated Fyn Phosphorylates α-Synuclein at Tyrosine Residue 125

Nakamura, T., Yamashita, H., Takahashi, T., & Nakamura, S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4253 · Cited by 135 · see citing works

Increased Expression of Rat Synuclein in the Substantia Nigra Pars Compacta Identified by mRNA Differential Display in a Model of Developmental Target Injury

Kholodilov, N. G., Neystat, M., Tinmarla, F. O., Steven, E. L., Larsen, K. E., Sulzer, D. L., & Burke, R. E. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0732586.x · Cited by 133 · see citing works

Cocaine Abusers Have an Overexpression of α-Synuclein in Dopamine Neurons

Mash, D. C., Ouyang, Q., Pablo, J. P., Basile, M. J., Izenwasser, S., LIEBERMAN, A. N., & Perrin, R. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02564.2003 · Cited by 127 · see citing works

Developmental expression of α-synuclein in rat hippocampus and cerebral cortex

Petersen, K. L., Olesen, O. F., & Mikkelsen, J. D. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00596-x · Cited by 125 · see citing works

α-Synuclein expression is modulated at the translational level by iron

Febbraro, F., Giorgi, M., Caldarola, S., Loreni, F., & Romero‐Ramos, M. (2012) · Neuroreport · doi:10.1097/wnr.0b013e328354a1f0 · Cited by 120 · see citing works

Synphilin-1 Is Developmentally Localized to Synaptic Terminals, and Its Association with Synaptic Vesicles Is Modulated by α-Synuclein

Ribeiro, C. S., Carneiro, K., Ross, C. A., Menezes, J. R. L., & Engelender, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201115200 · Cited by 119 · see citing works

NACP, a Synaptic Protein Involved in Alzheimer's Disease, Is Differentially Regulated during Megakaryocyte Differentiation

Hashimoto, M., Yoshimoto, M., Sisk, A., Hsu, L. J., Sundsmo, M. P., Kittel, Á., Saitoh, T., Miller, A. L., & Masliah, E. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6978 · Cited by 120 · see citing works

Chapter 6 Molecular and Cellular Biology of Synucleins

Surguchov, A. P. (2008) · International review of cytology · doi:10.1016/s1937-6448(08)01406-8 · Cited by 118 · see citing works

Modeling α-Synuclein Propagation with Preformed Fibril Injections

Chung, H. K., Ho, H.-A., Pérez-Acuña, D., & Lee, S. (2019) · Journal of Movement Disorders · doi:10.14802/jmd.19046 · Cited by 117 · see citing works

Physiology and Pathophysiology of α‐Synuclein: Cell Culture and Transgenic Animal Models Based on a Parkinson's Disease‐associated Protein

Kahle, P. J., Neumann, M., Ozmen, L., & Haass, C. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06902.x · Cited by 115 · see citing works

Calcium-Handling Defects and Neurodegenerative DiseasePreprint

Schrank, S., Barrington, N. M., & Stutzmann, G. E. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a035212 · Cited by 113 · see citing works

The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease

Campion, D., Martin, C., Heilig, R., Charbonnier, F., Moreau, V., Flaman, J., Petit, J., Hannequin, D., Brice, A., & Frébourg, T. (1995) · Genomics · doi:10.1016/0888-7543(95)80208-4 · Cited by 109 · see citing works

Brain neutral lipids mass is increased in α‐synuclein gene‐ablated mice

Barceló‐Coblijn, G., Golovko, M. Y., Weinhofer, I., Berger, J., & Murphy, E. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04348.x · Cited by 107 · see citing works

Polyunsaturated Fatty Acids Induce α-Synuclein-Related Pathogenic Changes in Neuronal Cells

Assayag, K., Yakunin, E., Loeb, V., Selkoe, D. J., & Sharon, R. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070373 · Cited by 106 · see citing works

Neurobiology of α-Synuclein

Vekrellis, K., Rideout, H. J., & Stefanis, L. (2004) · Molecular Neurobiology · doi:10.1385/mn:30:1:001 · Cited by 105 · see citing works

Organization, expression and polymorphism of the human persyn gene

Ninkina, N. N. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.9.1417 · Cited by 107 · see citing works

Degradative organelles containing mislocalized α- and β-synuclein proliferate in presenilin-1 null neurons

Wilson, C., Murphy, D. D., Giasson, B. I., Zhang, B., Trojanowski, J. Q., & Lee, V. M. ‐. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403061 · Cited by 106 · see citing works

Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

Imberdis, T., Negri, J. M., Ramalingam, N., Terry-Kantor, E., Ho, G. P. H., Fanning, S., Stirtz, G. L., Kim, T., Levy, O. A., Young‐Pearse, T. L., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903216116 · Cited by 105 · see citing works

α-Synuclein pathology as a target in neurodegenerative diseases

Park, H.-J., Kam, T., Dawson, V. L., & Dawson, T. M. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01043-w · Cited by 113 · see citing works

The usual suspects, dopamine and alpha‐synuclein, conspire to cause neurodegeneration

Mor, D. E., Daniels, M. J., & Ischiropoulos, H. (2019) · Movement Disorders · doi:10.1002/mds.27607 · Cited by 103 · see citing works

Mitochondrial Quality Control and Dynamics in Parkinson's Disease

McCoy, M. K., & Cookson, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4019 · Cited by 103 · see citing works

Epitope mapping of LB509, a monoclonal antibody directed against human α-synuclein

Jakes, R., Crowther, R. A., Lee, V. M. ‐., Trojanowski, J. Q., Iwatsubo, T., & Goedert, M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00411-5 · Cited by 103 · see citing works

Axonal transport of synucleins is mediated by all rate components

Jensen, P. H., Li, J., Dahlström, A. B., & Dotti, C. G. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00754.x · Cited by 102 · see citing works

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

Maroteaux, L., Campanelli, J., & Scheller, R. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02804.1988 · Cited by 1,646 · see citing works

Identification of an alternatively spliced avian member of the synaptophysin gene family

Bixby, J. L. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90217-y · Cited by 27 · see citing works

Synapsin I Gene expression in the adult rat brain with comparative analysis of mRNA and protein in the hippocampus

Melloni, R. H., Hemmendinger, L. M., Hamos, J. E., & DeGennaro, L. J. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903270404 · Cited by 57 · see citing works

Cloning and sequence analysis of the human cDNA encoding the synaptoporin (Δ), a highly conservative synaptic vesicle protein

Dai, J., Ji, C., Gu, S., Wu, Q., Wang, L., Xu, J., Zeng, L., Ye, X., Yin, G., Xie, Y., et al. (2003) · Molecular Biology Reports · doi:10.1023/a:1024907723000 · Cited by 4 · see citing works

Differential expression of synaptophysin and synaptoporin mRNAs in the postnatal rat central nervous system

Marquèze‐Pouey, B., Wisden, W., Malosio, M. L., & Betz, H. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03388.1991 · Cited by 98 · see citing works