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Interaction of human and mouse Aβ peptides
Abstract
Transgenic mice over‐expressing mutant human amyloid precursor protein have become an important tool for research on Alzheimer's disease (AD) and, in particular, for therapeutic screening. Many models have reported formation of amyloid plaques with age as is detected in AD. However, the plaques generated in transgenic mice are more soluble than human plaques. Differences in solubility may occur for a number of reasons; one proposal is the presence of murine Aβ peptides within the CNS milieu. Here, we report the interaction of human and murine Aβ peptides, Aβ40 and Aβ42, utilizing a fluorescence assay to monitor formation of mixed pre‐fibrillar aggregates, electron microscopy to examine morphological characteristics and detergent solubility to monitor stability. Our results demonstrate that interspecies Aβ aggregates and fibres are readily formed and are more stable than homogenous human fibres. Furthermore, these results suggest that the presence of endogenous murine Aβ in human APP transgenic mice does not account for the increased solubility of plaques.
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“Such data are not surprising given that in vitro data demonstrate that human and mouse Aβ can coassemble into aggregates (Fung et al., 2004).”
From Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice (2005) · cites this paper as Fung et al., 2004
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Cites
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Cited by
Sorted by citations
Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice
McGowan, E., Pickford, F., Kim, J., Onstead, L., Eriksen, J., Yu, C., Skipper, L., Murphy, M. P., Beard, J., Das, P., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.030 · Cited by 565
Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate
Stuber, G. D., Hnasko, T. S., Britt, J. P., Edwards, R. H., & Bonci, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1754-10.2010 · Cited by 529
A Blueprint for the Spatiotemporal Origins of Mouse Hippocampal Interneuron Diversity
Tricoire, L., Pelkey, K. A., Erkkila, B. E., Jeffries, B. W., Yuan, X., & McBain, C. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-11.2011 · Cited by 292
Mesocortical Dopamine Neurons Operate in Distinct Temporal Domains Using Multimodal Signaling
Lavin, A., Nogueira, L., Lapish, C. C., Wightman, R. M., Phillips, P. E. M., & Seamans, J. K. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0557-05.2005 · Cited by 233
Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice
Jankowsky, J. L., Younkin, L. H., Gonzales, V., Fadale, D. J., Slunt, H. H., Lester, H. A., Younkin, S. G., & Borchelt, D. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611050200 · Cited by 122
Metadata
- Authors
- Fung, J., Frost, D., Chakrabartty, A., & McLaurin, J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2004-12
- Volume
- 91
- Issue
- 6
- Pages
- 1398-1403
- ISSN
- 0022-3042
- 1471-4159
- Cited by
- 46
- References
- 3
- Language
- en
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