The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical‐scavenging activity
Open accessAbstract
Minocycline is neuroprotective in animal models of a number of acute CNS injuries and neurodegenerative diseases. While anti‐inflammatory and anti‐apoptotic effects of minocycline have been characterized, the molecular basis for the neuroprotective effects of minocycline remains unclear. We report here that minocycline and a number of antioxidant compounds protect mixed neuronal cultures in an oxidative stress assay. To evaluate the role of minocycline's direct antioxidant properties in neuroprotection, we determined potencies for minocycline, other tetracycline antibiotics, and reference antioxidant compounds using a panel of in vitro radical scavenging assays. Data from in vitro rat brain homogenate lipid peroxidation and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging assays show that minocycline, in contrast to tetracycline, is an effective antioxidant with radical scavenging potency similar to vitamin E. Our findings suggest that the direct antioxidant activity of minocycline may contribute to its neuroprotective effects in some cell‐based assays and animal models of neuronal injury.
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Cited by
Minocycline: Far beyond an Antibiotic
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935
Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
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Luo, H., Chen, J., Shi, L., Mikailov, M., Zhu, H., Wang, K., He, L., & Yang, L. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr299 · Cited by 206
Minocycline: Therapeutic Potential in Psychiatry
Dean, O. M., Data-Franco, J., Giorlando, F., & Berk, M. (2012) · CNS Drugs · doi:10.2165/11632000-000000000-00000 · Cited by 131
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Metadata
- Authors
- Kraus, R. L., Pasieczny, R., Lariosa‐Willingham, K., Turner, M. S., Jiang, A., & Trauger, J. W.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2005-06-22
- Volume
- 94
- Issue
- 3
- Pages
- 819-827
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1514649841
- Cited by
- 321
- References
- 33
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kraus, R. L., Pasieczny, R., Lariosa‐Willingham, K., Turner, M. S., Jiang, A., & Trauger, J. W. (2005). Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical‐scavenging activity. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2005.03219.x
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