The DOI matches its Crossref record; 195 of the 195 references it cites were found in a registry or an index.
3‐Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease
Abstract
Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the gene encoding Huntingtin. The mechanisms underlying the preferential degeneration of the striatum, the most striking neuropathological change in HD, are unknown. Of those probably involved, mitochondrial defects might play an important role. The behavioural and anatomical similarities found between HD and models using the mitochondrial toxin 3‐nitropropionic acid (3NP) in rats and primates support this hypothesis. Here, we discuss the recently identified mechanisms of 3NP‐induced striatal degeneration. Two types of important factor have been identified. The first are the ‘executioner’ components that have direct roles in cell death, such as c‐Jun N‐terminal kinase and Ca 2+‐activated protease calpains. The second are ‘environmental’ factors, such as glutamate, dopamine and adenosine, which modulate the striatal degeneration induced by 3NP. Interestingly, these recent studies support the hypothesis that 3NP and mutated Huntingtin have certain mechanisms of toxicity in common, suggesting that the use of 3NP might give new insights into the pathogenesis of HD. Research on 3NP provides additional proof that the neurochemical environment of a given neurone can determine its preferential vulnerability in neurodegenerative diseases.
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Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand
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S-Glutathionylation: From Molecular Mechanisms to Health Outcomes
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Metadata
- Authors
- Brouillet, E., Jacquard, C., Bizat, N., & Blum, D.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2005-11-21
- Volume
- 95
- Issue
- 6
- Pages
- 1521-1540
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2049387807
- Cited by
- 364
- References
- 195
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: 3‐Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. https://app.cochat.ai/papers/10.1111/j.1471-4159.2005.03515.x
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- Brouillet, E., Jacquard, C., Bizat, N., & Blum, D. (2005). 3‐Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2005.03515.x
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