The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Mitochondria, calcium and cell death: A deadly triad in neurodegeneration
Open accessAbstract
Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. The link between Ca2+ (dys)regulation, mitochondria and cellular derangement is particularly evident in neurodegenerative disorders, in which genetic models and environmental factors allowed to identify common traits in the pathogenic routes. We will here summarize: i) the current view of mechanisms and functions of mitochondrial Ca2+ homeostasis, ii) the basic principles of organelle Ca2+ transport, iii) the role of Ca2+ in neuronal cell death, and iv) the new information on the pathogenesis of Alzheimer's, Huntington's and Parkinson's diseases, highlighting the role of Ca2+ and mitochondria.
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Cites
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
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Oxidative Damage Is the Earliest Event in Alzheimer Disease
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“the channel more sensitive to Ca, was knocked out [74,75].”
BackgroundChaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels
Szabadkai, G., Bianchi, K., Várnai, P., De Stefani, D., Wieckowski, M. R., Cavagna, D., Nagy, A. I., Balla, T., & Rizzuto, R. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200608073 · Cited by 1,413
Self-citationThe mitochondrial calcium uniporter is a highly selective ion channel
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BAX and BAK Regulation of Endoplasmic Reticulum Ca 2+ : A Control Point for Apoptosis
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Cited by
Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration
Verma, M., Lizama, B. N., & Chu, C. T. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-021-00278-7 · Cited by 451
Recent advances in our understanding of neurodegeneration
Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274
Rossi, A., Rigotto, G., Valente, G., Giorgio, V., Basso, E., Filadi, R., & Pizzo, P. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.060 · Cited by 109
Self-citationMechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia
Han, Y., Yuan, M., Guo, Y.-S., Shen, X.-Y., Gao, Z.-K., & Bi, X. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.704334 · Cited by 105
Prakash, A., & Kumar, A. (2014) · Neurotoxicity Research · doi:10.1007/s12640-013-9437-9 · Cited by 98
Metadata
- Authors
- Celsi, F., Pizzo, P., Brini, M., Leo, S., Fotino, C., Pinton, P., & Rizzuto, R.
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 1787
- Issue
- 5
- Pages
- 335-344
- ISSN
- 0005-2728 (ISSN-L)
- OpenAlex
- W2139989763
- Cited by
- 323
- References
- 113
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Celsi, F., Pizzo, P., Brini, M., Leo, S., Fotino, C., Pinton, P., & Rizzuto, R. (2009). Mitochondria, calcium and cell death: A deadly triad in neurodegeneration. Biochimica et Biophysica Acta (BBA) - Bioenergetics. https://doi.org/10.1016/j.bbabio.2009.02.021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
