The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo
Abstract
Inhibitory molecules derived from CNS myelin and glial scar tissue are major causes for insufficient functional regeneration in the mammalian CNS. A multitude of these molecules signal through the Rho/Rho kinase (ROCK) pathway. We evaluated three inhibitors of ROCK, Y- 27632, Fasudil (HA-1077), and Dimethylfasudil (H-1152), in models of neurite outgrowth in vitro. We show, that all three ROCK inhibitors partially restore neurite outgrowth of Ntera-2 neurons on the inhibitory chondroitin sulphate proteoglycan substrate. In the rat optic nerve crush model Y-27632 dose-dependently increased regeneration of retinal ganglion cell axons in vivo. Application of Dimethylfasudil showed a trend towards increased axonal regeneration in an intermediate concentration. We demonstrate that inhibition of ROCK can be an effective therapeutic approach to increase regeneration of CNS neurons. The selection of a suitable inhibitor with a broad therapeutic window, however, is crucial in order to minimize unwanted side effects and to avoid deleterious effects on nerve fiber growth.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It integrates molecular signals to organize sophisticated and coordinated variations in gene expression and actin cytoskeleton, crucial processes for the neurite outgrowth and synaptic connectivity [53,54].”
From Brain Cholesterol Biosynthetic Pathway Is Altered in a Preclinical Model of Fragile X Syndrome (2022) · cites this paper as [53]
Citations
Cites
Specificity and mechanism of action of some commonly used protein kinase inhibitors
DAVIES, S. P., Reddy, H., Caivano, M., & Cohen, P. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510095 · Cited by 4,372
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
Yang, N., Higuchi, O., Ohashi, K., Nagata, K., Wada, A., Kangawa, K., Nishida, E., & Mizuno, K. (1998) · Nature · doi:10.1038/31735 · Cited by 1,296
Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
Ishizaki, T., Uehata, M., Tamechika, I., Keel, J., Nonomura, K., Maekawa, M., & Narumiya, S. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26508-1 · Cited by 940
LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
Mi, S., Lee, X., Shao, Z., Thill, G., Ji, B., Relton, J. K., Levesque, M., Allaire, N., Perrin, S., Sands, B., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1188 · Cited by 827
Rho Signaling Pathway Targeted to Promote Spinal Cord Repair
Dergham, P., Ellezam, B., Essagian, C., Avedissian, H., Lubell, W. D., & McKerracher, L. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06570.2002 · Cited by 725
Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS
Fournier, A. E., Takizawa, B. T., & Strittmatter, S. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01416.2003 · Cited by 644
cAMP-induced switching in turning direction of nerve growth cones
Song, H., Ming, G., & Poo, M.-M. (1997) · Nature · doi:10.1038/40864 · Cited by 620
Rho kinase, a promising drug target for neurological disorders
Mueller, B. K., Mack, H., & Teusch, N. E. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1719 · Cited by 609
Self-citationLang, P., Gesbert, F., Delespine‐Carmagnat, M., Stancou, R., Pouchelet, M., & Bertoglio, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00383.x · Cited by 558
Shamah, S. M., Lin, M. Z., Goldberg, J. L., Estrach, S., Şahin, M., Hu, L. S., Bazalakova, M. H., Neve, R. L., Corfas, G., Debant, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00314-2 · Cited by 544
Research works printed but not linked: 1
- 10.1042/bj3510095 · DOI
Cited by
Sorted by citations
Items 201–215 of 215
[Formation of pedigrees for recombinational analysis of recessive traits].
Aksenovich, T. I., & Av, F. (1998) · PubMed
The role of novel genes in CNS axon regeneration
Almutiri, S. (2017) · University of Birmingham Institutional Research Archive (University of Birmingham)
Tharmalingam, S. (2014) · TSpace (University of Toronto)
MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
Pearson, C. S. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.32374
Research progress on optic nerve injury and regeneration
Liu, X., Hao, F., Duan, H., Hao, P., Gao, Y., Zhao, W., Yang, Z., & XiaoGuang, L. I. (2022) · Scientia Sinica Vitae · doi:10.1360/ssv-2022-0055
Adaptive synaptic mechanisms: The role of metaplasticity in synaptic tagging and capture
Jayapragas, S., Yin, L. S., & Sajikumar, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00065-1
Saijilafu, Chen, P., Ye, L., Shen, Y., Wang, Q., Chen, X., Chimedtseren, C., Zhang, J., Fang, L., & Xu, R. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1634999
Biomarqueurs rétiniens de la maladie d'Alzheimer et du vieillissement cérébral
Gomez, J. L. M. (2016) · theses.fr (ABES) · doi:10.70675/477e6a1ez209az4a71za0c6z8629c2d7e785
Molecular mechanisms orchestrating commissural axon guidance
Roig‐Puiggros, S. (2019) · theses.fr (ABES) · doi:10.70675/9709d6aaz37b7z4de2za537zd7f1bf648566
Diversity of visual projections in vertebrates
Vigouroux, R. J. (2020) · theses.fr (ABES) · doi:10.70675/4e013149z524az4f80za5c1z99a2ca079cb0
Extrinsic Regulation of Optic Nerve Axon Regeneration in the Adult Central Nervous System
Adhikary, A., Dorairaj, E. A., Arshavsky, A., Ramcharan, S., Kishor, K. S., & Bhattacharya, S. K. (2026) · Cells · doi:10.3390/cells15171510
Direct and Indirect Modulators of TDP-43 Aggregation in vitro
Caicedo, K. M. R. (2026) · Digital Commons - DU (University of Denver) · doi:10.56902/etdcrp.2026.187
BindingDB Entry 50008471: The Rise of Molecules Able To Regenerate the Central Nervous System.
BindingDB (2021) · UC San Diego · doi:10.7270/q2nc64kv
Metadata
- Authors
- Lingor, P., Teusch, N., Schwarz, K., Mueller, R., Mack, H., Bähr, M., & Mueller, B. K.
- Affiliations
- University of Göttingen (DE)
- Abbott (Germany) (DE)
- Corresponding author
- Bähr, Mathias
- Mueller, Bernhard K.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2007-06-09
- Volume
- 103
- Issue
- 1
- Pages
- 181-189
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2011497398
- Cited by
- 214
- References
- 37
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 13 · 2021: 5 · 2020: 14 · 2019: 9 · 2018: 15 · 2017: 10 · 2016: 17 · 2015: 15 · 2014: 23 · 2013: 17 · 2012: 14
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- Rho kinase inhibition, ROCK inhibitor, neurite outgrowth, chondroitin sulfate proteoglycans, axon regeneration, optic nerve crush, retinal ganglion cells, Y-27632, fasudil, glial scar, central nervous system regeneration
- MeSH terms
- Amides, Animals, Axons, Cell Line, Dose-Response Relationship, Drug, Enzyme Inhibitors, Female, Humans, Nerve Crush, Nerve Regeneration, Neurons, Optic Nerve, Chondroitin Sulfate Proteoglycans, Pyridines, Neurites, Rats, Wistar, Protein Serine-Threonine Kinases, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, Optic Nerve Injuries, Intracellular Signaling Peptides and Proteins, Rats, rho-Associated Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
