Cited by 215Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

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Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo

Lingor, Paul, Teusch, Nicole, Schwarz, Katrin, Mueller, Reinhold, Mack, Helmut, Bähr, Mathias, Mueller, Bernhard K.·2007·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2007.04756.x

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Abstract

Inhibitory molecules derived from CNS myelin and glial scar tissue are major causes for insufficient functional regeneration in the mammalian CNS. A multitude of these molecules signal through the Rho/Rho kinase (ROCK) pathway. We evaluated three inhibitors of ROCK, Y- 27632, Fasudil (HA-1077), and Dimethylfasudil (H-1152), in models of neurite outgrowth in vitro. We show, that all three ROCK inhibitors partially restore neurite outgrowth of Ntera-2 neurons on the inhibitory chondroitin sulphate proteoglycan substrate. In the rat optic nerve crush model Y-27632 dose-dependently increased regeneration of retinal ganglion cell axons in vivo. Application of Dimethylfasudil showed a trend towards increased axonal regeneration in an intermediate concentration. We demonstrate that inhibition of ROCK can be an effective therapeutic approach to increase regeneration of CNS neurons. The selection of a suitable inhibitor with a broad therapeutic window, however, is crucial in order to minimize unwanted side effects and to avoid deleterious effects on nerve fiber growth.

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DAVIES, S. P., Reddy, H., Caivano, M., & Cohen, P. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510095 · Cited by 4,366
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
Yang, N., Higuchi, O., Ohashi, K., Nagata, K., Wada, A., Kangawa, K., Nishida, E., & Mizuno, K. (1998) · Nature · doi:10.1038/31735 · Cited by 1,296
Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
Ishizaki, T., Uehata, M., Tamechika, I., Keel, J., Nonomura, K., Maekawa, M., & Narumiya, S. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26508-1 · Cited by 940
LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
Mi, S., Lee, X., Shao, Z., Thill, G., Ji, B., Relton, J. K., Levesque, M., Allaire, N., Perrin, S., Sands, B., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1188 · Cited by 827
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Dergham, P., Ellezam, B., Essagian, C., Avedissian, H., Lubell, W. D., & McKerracher, L. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06570.2002 · Cited by 725
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Fournier, A. E., Takizawa, B. T., & Strittmatter, S. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01416.2003 · Cited by 644
cAMP-induced switching in turning direction of nerve growth cones
Song, H., Ming, G., & Poo, M.-M. (1997) · Nature · doi:10.1038/40864 · Cited by 620
Rho kinase, a promising drug target for neurological disorders
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Lang, P., Gesbert, F., Delespine‐Carmagnat, M., Stancou, R., Pouchelet, M., & Bertoglio, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00383.x · Cited by 558
EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin
Shamah, S. M., Lin, M. Z., Goldberg, J. L., Estrach, S., Şahin, M., Hu, L. S., Bazalakova, M. H., Neve, R. L., Corfas, G., Debant, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00314-2 · Cited by 544

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Authors: Lingor, P., Teusch, N., Schwarz, K., Mueller, R., Mack, H., Bähr, M., & Mueller, B. K.
Affiliations: University of Göttingen (DE)
Abbott (Germany) (DE)
Corresponding author: Bähr, Mathias
Mueller, Bernhard K.
ORCID: Lingor, Paul
Teusch, Nicole
Bähr, Mathias
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2007-06-09
Volume: 103
Issue: 1
Pages: 181-189
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2007.04756.x
OpenAlex: W2011497398
Cited by: 214
References: 37
Citations by year: 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 13 · 2021: 5 · 2020: 14 · 2019: 9 · 2018: 15 · 2017: 10 · 2016: 17 · 2015: 15 · 2014: 23 · 2013: 17 · 2012: 14
FWCI: 4.10
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
GRO (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords: Rho kinase inhibition, ROCK inhibitor, neurite outgrowth, chondroitin sulfate proteoglycans, axon regeneration, optic nerve crush, retinal ganglion cells, Y-27632, fasudil, glial scar, central nervous system regeneration
MeSH terms: Amides, Animals, Axons, Cell Line, Dose-Response Relationship, Drug, Enzyme Inhibitors, Female, Humans, Nerve Crush, Nerve Regeneration, Neurons, Optic Nerve, Chondroitin Sulfate Proteoglycans, Pyridines, Neurites, Rats, Wistar, Protein Serine-Threonine Kinases, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, Optic Nerve Injuries, Intracellular Signaling Peptides and Proteins, Rats, rho-Associated Kinases

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Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo

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