The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
Open accessAbstract
The most striking morphologic change in neurons during normal aging is the accumulation of autophagic vacuoles filled with lipofuscin or neuromelanin pigments. These organelles are similar to those containing the ceroid pigments associated with neurologic disorders, particularly in diseases caused by lysosomal dysfunction. The pigments arise from incompletely degraded proteins and lipids principally derived from the breakdown of mitochondria or products of oxidized catecholamines. Pigmented autophagic vacuoles may eventually occupy a major portion of the neuronal cell body volume because of resistance of the pigments to lysosomal degradation and/or inadequate fusion of the vacuoles with lysosomes. Although the formation of autophagic vacuoles via macroautophagy protects the neuron from cellular stress, accumulation of pigmented autophagic vacuoles may eventually interfere with normal degradative pathways and endocytic/secretory tasks such as appropriate response to growth factors.
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Cited by
The role of autophagy in neurodegenerative disease
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Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
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Pathogenic Lysosomal Depletion in Parkinson's Disease
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Human iPSC-based modeling of late-onset disease via progerin-induced aging
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Metadata
- Authors
- Sulzer, D., Mosharov, E., Talloczy, Z., Zucca, F. A., Simon, J. D., & Zecca, L.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2008-04
- Volume
- 106
- Issue
- 1
- Pages
- 24-36
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2055902281
- Cited by
- 191
- References
- 10
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease. https://app.cochat.ai/papers/10.1111/j.1471-4159.2008.05385.x
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- Sulzer, D., Mosharov, E., Talloczy, Z., Zucca, F. A., Simon, J. D., & Zecca, L. (2008). Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.2008.05385.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
