Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417 · see citing works

Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons

Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862 · see citing works

Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter

Bellocchio, E. E., Reimer, R. J., Fremeau, R. T., & Edwards, R. H. (2000) · Science · doi:10.1126/science.289.5481.957 · Cited by 795 · see citing works

Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis

Maechler, P., & Wollheim, C. B. (1999) · Nature · doi:10.1038/45280 · Cited by 507 · see citing works

ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

Hay, J. C., Fisette, P. L., Jenkins, G. H., Fukami, K., Takenawa, T., Anderson, R. A., & Martin, T. F. J. (1995) · Nature · doi:10.1038/374173a0 · Cited by 506 · see citing works

Neurotransmitter release — four years of SNARE complexes

Hanson, P. I., Heuser, J. E., & Jahn, R. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80057-8 · Cited by 394 · see citing works

Protein kinase A‐dependent and ‐independent stimulation of exocytosis by cAMP in mouse pancreatic B‐cells

Renström, E., Eliasson, L., & Rorsman, P. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.105bl.x · Cited by 299 · see citing works

Exocytosis elicited by action potentials and voltage‐clamp calcium currents in individual mouse pancreatic B‐cells.

Ammälä, C., Eliasson, L., Bokvist, K., Larsson, O., Ashcroft, F. M., & Rorsman, P. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019966 · Cited by 270 · see citing works

Ultrastructural morphometry of the pancreatic ?-cell

Dean, P. M. (1973) · Diabetologia · doi:10.1007/bf01230690 · Cited by 263 · see citing works

Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells.

Gembal, M., Detimary, P., Gilon, P., Gao, Z. Y., & Henquin, J. C. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116308 · Cited by 260 · see citing works

A low affinity Ca2+ receptor controls the final steps in peptide secretion from pituitary melanotrophs

Thomas, P., Wong, J. G., Lee, A. K., & Almers, W. (1993) · Neuron · doi:10.1016/0896-6273(93)90274-u · Cited by 244 · see citing works

Rapid ATP‐Dependent Priming of Secretory Granules Precedes Ca ²⁺ ‐Induced Exocytosis in Mouse Pancreatic B‐Cells

Eliasson, L., Renström, E., Ding, W., Proks, P., & Rorsman, P. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.399bh.x · Cited by 223 · see citing works

PKC-Dependent Stimulation of Exocytosis by Sulfonylureas in Pancreatic β Cells

Eliasson, L., Renström, E., Ämmälä, C., Berggren, P., Bertorello, A. M., Bokvist, K. B., Chibalin, A., Deeney, J. T., Flatt, P. R., Gäbel, J., et al. (1996) · Science · doi:10.1126/science.271.5250.813 · Cited by 193 · see citing works

The insulin secretory granule

Hutton, J. C. (1989) · Diabetologia · doi:10.1007/bf00265542 · Cited by 192 · see citing works

The Interaction of nucleotides with the tolbutamide block of cloned atp‐sensitive k⁺ channel currents expressed in xenopus oocytes: a reinterpretation

Gribble, F. M., Tucker, S. J., & Ashcroft, F. M. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.00035.x · Cited by 161 · see citing works

Regulation of Human CLC-3 Channels by Multifunctional Ca2+/Calmodulin-dependent Protein Kinase

Huang, P., Liu, J., Di, A., Robinson, N. C., Musch, M. W., Kaetzel, M. A., & Nelson, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009376200 · Cited by 149 · see citing works

Elemental composition of secretory granules in pancreatic islets of Langerhans

Foster, M. C., Leapman, R. D., Li, M. X., & Atwater, I. J. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81397-3 · Cited by 139 · see citing works

Cooling inhibits exocytosis in single mouse pancreatic B‐cells by suppression of granule mobilization.

Renström, E., Eliasson, L., Bokvist, K. B., & Rorsman, P. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021474 · Cited by 102 · see citing works

The pH‐Sensitive Dye Acridine Orange as a Tool to MonitorExocytosis/Endocytosis in Synaptosomes

Zoccarato, F., Cavallini, L., & Alexandre, A. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720625.x · Cited by 101 · see citing works

Irreversible swelling of secretory granules during exocytosis caused by calcium

Zimmerberg, J. J., & Whitaker, M. (1985) · Nature · doi:10.1038/315581a0 · Cited by 100 · see citing works

Interrelationship between chloride fluxes in pancreatic islets and insulin release.

Sehlin, J. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.235.5.e501 · Cited by 83 · see citing works

Soluble N-ethylmaleimide-sensitive-factor attachment protein and N-ethylmaleimide-insensitive factors are required for Ca2+-stimulated exocytosis of insulin

Kiraly‐Borri, C., Morgan, A., Burgoyne, R. D., WELLER, U., Wollheim, C. B., & Lang, J. (1996) · Biochemical Journal · doi:10.1042/bj3140199 · Cited by 70 · see citing works

Chloride channels of intracellular organelles and their potential role in cystic fibrosis

Al‐Awqati, Q., Barasch, J. M., & Landry, D. W. (1992) · Journal of Experimental Biology · doi:10.1242/jeb.172.1.245 · Cited by 69 · see citing works

The stimulatory action of tolbutamide on Ca 2+ -dependent exocytosis in pancreatic β cells is mediated by a 65-kDa mdr-like P-glycoprotein

Barg, S., Renström, E., Berggren, P., Bertorello, A. M., Bokvist, K. B., Braun, M., Eliasson, L., Holmes, W. E., Köhler, M. G., Rorsman, P., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5539 · Cited by 67 · see citing works

Cytosolic chloride ions stimulate Ca2+‐induced exocytosis in melanotrophs

Rupnik, M. S., & Zorec, R. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80524-k · Cited by 50 · see citing works

Identification of ClC-2-like chloride currents in pig pancreatic acinar cells

Carew, M. A., & Thorn, P. (1996) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050252 · Cited by 44 · see citing works

The chromaffin granule proton pump and calcium-dependent exocytosis in bovine adrenal medullary cells

KNIGHT, D. E., & Baker, P. F. (1985) · The Journal of Membrane Biology · doi:10.1007/bf01868746 · Cited by 44 · see citing works

Ionic and osmotic dependence of secretion from permeabilised acini of the rat pancreas

Fuller, C. M., Eckhardt, L., & Schulz, I. (1989) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584488 · Cited by 40 · see citing works

Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial‐like ATP‐sensitive K⁺ (K_ATP) conductance in rat pancreatic A‐cells

Høy, M., Olsen, H. L., Bokvist, K., Buschard, K., Barg, S., Rorsman, P., & Gromada, J. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00109.x · Cited by 32 · see citing works

ATP sensitive K+ conductance in pancreatic zymogen granules: Block by glyburide and activation by diazoxide

Thévenod, F., Chathadi, K. V., Jiang, B., & Hopfer, U. (1992) · Journal of Membrane Biology · doi:10.1007/bf00232907 · Cited by 24 · see citing works

Osmotic regulation of prolactin secretion. Possible role of chloride.

Day, R. N., & Hinkle, P. M. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37536-7 · Cited by 23 · see citing works

Evidence for a 65 kDa sulfonylurea receptor in rat pancreatic zymogen granule membranes

Braun, M., Anderie, I., & Thévenod, F. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00711-4 · Cited by 18 · see citing works

ATP-sensitive K+ channel-independent, insulinotropic action of glucose in the B-cells.

Aizawa, T., Sato, Y., Komatsu, M., & Hashizume, K. (1992) · PubMed · Cited by 18 · see citing works

Potentiation of Quantal Catecholamine Secretion by Glibenclamide: Evidence for a Novel Role of Sulphonylurea Receptors in Regulating the Ca2+Sensitivity of Exocytosis

Taylor, S. C., Carpenter, E. P., Roberts, M. L., & Peers, C. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05741.1999 · Cited by 16 · see citing works

Insulin granule dynamics in pancreatic beta cells

Rorsman, P., & Renstr�m, E. (2003) · Diabetologia · doi:10.1007/s00125-003-1153-1 · Cited by 844 · see citing works

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works

Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes

Fu, Z., Gilbert, E. R., & Liu, D. (2012) · Current Diabetes Reviews · doi:10.2174/157339913804143225 · Cited by 882 · see citing works

Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.

Fu, Z., Gilbert, E. R., & Liu, D. (2013) · PubMed · Cited by 600 · see citing works

PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis

Seino, S., & Shibasaki, T. (2005) · Physiological Reviews · doi:10.1152/physrev.00001.2005 · Cited by 558 · see citing works

CFTR regulates phagosome acidification in macrophages and alters bactericidal activity

Di, A., Brown, M. E., Deriy, L. V., Li, C., Szeto, F. L., Chen, Y., Huang, P. C., Tong, J., Naren, A. P., Bindokas, V. P., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1456 · Cited by 494 · see citing works

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476 · see citing works

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease

Jentsch, T. J., & Pusch, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00047.2017 · Cited by 452 · see citing works

<scp>GLP</scp> ‐1 receptor activated insulin secretion from pancreatic β‐cells: mechanism and glucose dependence

Meloni, A. R., DeYoung, M. B., Lowe, C., & Parkes, D. G. (2013) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01663.x · Cited by 407 · see citing works

Mechanisms of biphasic insulin-granule exocytosis – roles of the cytoskeleton, small GTPases and SNARE proteins

Wang, Z., & Thurmond, D. C. (2009) · Journal of Cell Science · doi:10.1242/jcs.034355 · Cited by 386 · see citing works

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

Seino, S., Shibasaki, T., & Minami, K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45680 · Cited by 364 · see citing works

Glucose-sensing mechanisms in pancreatic β-cells

Macdonald, P., Joseph, J., & Rorsman, P. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1762 · Cited by 270 · see citing works

Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function

Rowlands, J., Heng, J., Newsholme, P., & Carlessi, R. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00672 · Cited by 302 · see citing works

Hyperinsulinism in Infancy: From Basic Science to Clinical Disease

Dunne, M. J., Cosgrove, K. E., Shepherd, R. M., Aynsley-Green, A., & Lindley, K. J. (2004) · Physiological Reviews · doi:10.1152/physrev.00022.2003 · Cited by 294 · see citing works

Cell physiology of cAMP sensor Epac

Holz, G. G., Kang, G., Harbeck, M. C., Roe, M. W., & Chepurny, O. G. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.119644 · Cited by 275 · see citing works

SUR1 Regulates PKA-independent cAMP-induced Granule Priming in Mouse Pancreatic B-cells

Eliasson, L., Ma, X., Renström, E., Barg, S., Berggren, P.-O., Galvanovskis, J., Gromada, J., Jing, X., Lundquist, I., Salehi, A., et al. (2003) · The Journal of General Physiology · doi:10.1085/jgp.20028707 · Cited by 257 · see citing works

Fast Exocytosis with Few Ca2+ Channels in Insulin-Secreting Mouse Pancreatic B Cells

Barg, S., Ma, X., Eliasson, L., Galvanovskis, J., Göpel, S. O., Obermüller, S., Platzer, J., Renström, E., Trus, M., Atlas, D., et al. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75964-4 · Cited by 255 · see citing works

A Subset of 50 Secretory Granules in Close Contact With <scp>l</scp>-Type Ca2+ Channels Accounts for First-Phase Insulin Secretion in Mouse β-Cells

Barg, S., Eliasson, L., Renström, E., & Rorsman, P. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s74 · Cited by 227 · see citing works

PHYSIOLOGICAL FUNCTIONS OF CLC Cl−CHANNELS GLEANED FROM HUMAN GENETIC DISEASE AND MOUSE MODELS

Jentsch, T. J., Poët, M., Fuhrmann, J. C., & Zdebik, A. A. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.032003.153245 · Cited by 227 · see citing works

cAMP signalling in insulin and glucagon secretion

Tengholm, A., & Gylfe, E. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12993 · Cited by 223 · see citing works

Chloride in Vesicular Trafficking and Function

Stauber, T., & Jentsch, T. J. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183702 · Cited by 216 · see citing works

Cytokine Activation of Nuclear Factor κB in Vascular Smooth Muscle Cells Requires Signaling Endosomes Containing Nox1 and ClC-3

Miller, F. J., Filali, M. S., Huss, G. J., Stanić, B., Chamseddine, A., Barna, T. J., & Lamb, F. S. (2007) · Circulation Research · doi:10.1161/circresaha.107.151076 · Cited by 214 · see citing works

Signaling Components of Redox Active Endosomes: The Redoxosomes

Oakley, F. D., Abbott, D., Li, Q., & Engelhardt, J. F. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2363 · Cited by 209 · see citing works

The a 3 isoform of V-ATPase regulates insulin secretion from pancreatic β-cells

Sun‐Wada, G., Toyomura, T., Murata, Y., Yamamoto, A., Futai, M., & Wada, Y. (2006) · Journal of Cell Science · doi:10.1242/jcs.03234 · Cited by 209 · see citing works

The insulin secretory granule as a signaling hub

Suckale, J., & Solimena, M. (2010) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2010.06.003 · Cited by 201 · see citing works

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

Sulzer, D., Mosharov, E. V., Tallóczy, Z., Zucca, F. A., Simon, J. D., & Zecca, L. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05385.x · Cited by 190 · see citing works

CAPS Acts at a Prefusion Step in Dense-Core Vesicle Exocytosis as a PIP2 Binding Protein

Grishanin, R. N., Kowalchyk, J. A., Klenchin, V. A., Ann, K., Earles, C. A., Chapman, E. R., Gerona, R. R. L., & Martin, T. F. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.028 · Cited by 182 · see citing works

How versatile are inositol phosphate kinases?

Shears, S. B. (2004) · Biochemical Journal · doi:10.1042/bj20031428 · Cited by 173 · see citing works

Glucose Stimulates Glucagon Release in Single Rat α-Cells by Mechanisms that Mirror the Stimulus-Secretion Coupling in β-Cells

Olsen, H. L., Theander, S., Bokvist, K., Buschard, K., Wollheim, C. B., & Gromada, J. (2005) · Endocrinology · doi:10.1210/en.2005-0800 · Cited by 156 · see citing works

Proteomics Analysis of Insulin Secretory Granules

Brunner, Y., Couté, Y., Iezzi, M., Foti, M., Fukuda, M., Hochstrasser, D. F., Wollheim, C. B., & Sanchez, J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600443-mcp200 · Cited by 153 · see citing works

Mechanisms of the amplifying pathway of insulin secretion in the β cell

Kalwat, M. A., & Cobb, M. H. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.003 · Cited by 143 · see citing works

Cell Biology and Physiology of CLC Chloride Channels and Transporters

Stauber, T., Weinert, S., & Jentsch, T. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110038 · Cited by 145 · see citing works

Epac: effectors and biological functions

Roscioni, S. S., Elzinga, C. R. S., & Schmidt, M. (2008) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-007-0246-7 · Cited by 137 · see citing works

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

Edlund, A., Esguerra, J. L. S., Wendt, A., Flodström‐Tullberg, M., & Eliasson, L. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-87 · Cited by 138 · see citing works

Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins

Thévenod, F. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00600.2001 · Cited by 136 · see citing works

Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages

Deriy, L. V., Gomez, E. A., Zhang, G., Beacham, D. W., Hopson, J. A., Gallan, A. J., Shevchenko, P. D., Bindokas, V. P., & Nelson, D. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.057372 · Cited by 135 · see citing works

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic β cells

MacDonald, P. E., Braun, M., Galvanovskis, J., & Rorsman, P. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.08.011 · Cited by 133 · see citing works

Acidification and Protein Traffic

Weisz, O. A. (2003) · International review of cytology · doi:10.1016/s0074-7696(03)01005-2 · Cited by 122 · see citing works

The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery

Poëa‐Guyon, S., Ammar, M. R., Erard, M., Amar, M., Moreau, A. W., Fossier, P., Gleize, V., Vitale, N., & Morel, N. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201303104 · Cited by 121 · see citing works

Diverse and essential roles of mammalian vacuolar-type proton pump ATPase: toward the physiological understanding of inside acidic compartments

Sun‐Wada, G., Wada, Y., & Futai, M. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.04.013 · Cited by 119 · see citing works

Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels

Dickerson, L. W., Bonthius, D. J., Schutte, B. C., Yang, B., Barna, T. J., Bailey, M. C., Nehrke, K. W., Williamson, R. A., & Lamb, F. S. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03519-9 · Cited by 105 · see citing works

Glucagon‐Like Peptide‐1: Regulation of Insulin Secretion and Therapeutic Potential

Gromada, J., Brock, B., Schmitz, O., & Rorsman, P. (2004) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2004.t01-1-pto950502.x · Cited by 105 · see citing works

Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation

Ren, J., Jin, P., Wang, E., Liu, E., Harlan, D. M., Li, X., & Stroncek, D. F. (2007) · Journal of Translational Medicine · doi:10.1186/1479-5876-5-1 · Cited by 104 · see citing works

Stimulation‐dependent regulation of the ph, volume and quantal size of bovine and rodent secretory vesicles

Pothos, E. N., Mosharov, E. V., Liu, K., Setlik, W., Haburčák, M., Baldini, G., Gershon, M. D., Tamir, H., & Sulzer, D. L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.018630 · Cited by 102 · see citing works

The Pancreatic β-Cell: A Bioenergetic Perspective

Nicholls, D. G. (2016) · Physiological Reviews · doi:10.1152/physrev.00009.2016 · Cited by 95 · see citing works

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells

Olsen, H. L., Høy, M., Zhang, W., Bertorello, A. M., Bokvist, K., Capito, K., Efanov, A. M., Meister, B., Thams, P., Yang, S.-N., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931282100 · Cited by 101 · see citing works

Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent

Matsuda, J. J., Filali, M. S., Volk, K. A., Collins, M. M., Moreland, J. G., & Lamb, F. S. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00338.2007 · Cited by 93 · see citing works

Ionic mechanisms in pancreatic β cell signaling

Yang, S. N., Shi, Y., Yang, G., Li, Y., Yu, J. H., & Berggren, P. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1680-6 · Cited by 91 · see citing works

Role of H+-ATPase-mediated Acidification in Sorting and Release of the Regulated Secretory Protein Chromogranin A

Taupenot, L., Harper, K. L., & O’Connor, D. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408197200 · Cited by 83 · see citing works

GABA _B receptor activation inhibits exocytosis in rat pancreatic β‐cells by G‐protein‐dependent activation of calcineurin

Braun, M., Wendt, A., Buschard, K., Salehi, A., Sewing, S., Gromada, J., & Rorsman, P. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.066563 · Cited by 80 · see citing works

Role of furin in granular acidification in the endocrine pancreas: Identification of the V-ATPase subunit Ac45 as a candidate substrate

Louagie, E., Taylor, N. A., Flamez, D., Roebroek, A., Bright, N. A., Meulemans, S. M. P., Quintens, R., Herrera, P. L., Schuit, F. C., de Ven, W. J. M. V., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800340105 · Cited by 80 · see citing works

Increase in cellular glutamate levels stimulates exocytosis in pancreatic β‐cells

Høy, M., Maechler, P., Efanov, A. M., Wollheim, C. B., Berggren, P., & Gromada, J. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03500-7 · Cited by 78 · see citing works

Mechanisms of Exocytosis in Insulin‐Secreting B‐Cells and Glucagon‐Secreting A‐Cells

Barg, S. (2003) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2003.920102.x · Cited by 75 · see citing works

PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

Chepurny, O., Kelley, G., Dzhura, I., Leech, C. A., Roe, M., Dzhura, E., Li, X., Schwede, F., Genieser, H., & Holz, G. G. (2010) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00630.2009 · Cited by 80 · see citing works

Role of the Vesicular Chloride Transporter ClC-3 in Neuroendocrine Tissue

Maritzen, T., Keating, D. J., Neagoe, I., Zdebik, A. A., & Jentsch, T. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3750-08.2008 · Cited by 74 · see citing works

Chloride channels in the kidney: lessons learned from knockout animals

Devuyst, O., & Guggino, W. B. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00184.2002 · Cited by 72 · see citing works

Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic -cells

Hatanaka, M., Tanabe, K., Yanai, A., Ohta, Y., Kondo, M., Akiyama, M., Shinoda, K., Oka, Y., & Tanizawa, Y. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddq568 · Cited by 71 · see citing works

Identification of an N‐terminal amino acid of the CLC‐3 chloride channel critical in phosphorylation‐dependent activation of a CaMKII‐activated chloride current

Robinson, N. C., Huang, P., Kaetzel, M. A., Lamb, F. S., & Nelson, D. J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058032 · Cited by 69 · see citing works

The Granular Chloride Channel ClC-3 Is Permissive for Insulin Secretion

Deriy, L. V., Gomez, E. A., Jacobson, D. A., Wang, X., Hopson, J. A., Liu, X. Y., Zhang, G., Bindokas, V. P., Philipson, L. H., & Nelson, D. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.012 · Cited by 67 · see citing works

Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated Rescue of Exocytotic Defects in Munc13-1–Deficient Pancreatic β-Cells

Kwan, E. P., Xie, L., Sheu, L., Ohtsuka, T., & Gaisano, H. Y. (2007) · Diabetes · doi:10.2337/db06-1207 · Cited by 66 · see citing works

A Role for Glutamate Transporters in the Regulation of Insulin Secretion

Gammelsæter, R., Coppola, T., Marcaggi, P., Storm‐Mathisen, J., Chaudhry, F. A., Attwell, D., Regazzi, R., & Gundersen, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022960 · Cited by 64 · see citing works

Molecular Defects in Insulin Secretion in Type-2 Diabetes

Ashcroft, F. M., & Rorsman, P. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000021435.87776.a7 · Cited by 63 · see citing works

Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes

Fu, Z., Gilbert, E. R., & Liu, D. (2012) · Current Diabetes Reviews · doi:10.2174/15733998130104 · Cited by 68 · see citing works

The signaling role for chloride in the bidirectional communication between neurons and astrocytes

Wilson, C. S., & Mongin, A. A. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.01.012 · Cited by 62 · see citing works

Glucose-induced changes of multiple mouse islet proteins analysed by two-dimensional gel electrophoresis and mass spectrometry

Ahmed, M., & Bergsten, P. (2005) · Diabetologia · doi:10.1007/s00125-004-1661-7 · Cited by 62 · see citing works

The ClC-3 Cl−/H+ Antiporter Becomes Uncoupled at Low Extracellular pH

Matsuda, J. J., Filali, M. S., Collins, M. M., Volk, K. A., & Lamb, F. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018002 · Cited by 59 · see citing works

Inside the Insulin Secretory Granule

Germanos, M., Gao, A., Taper, M., Yau, B., & Kebede, M. A. (2021) · Metabolites · doi:10.3390/metabo11080515 · Cited by 56 · see citing works

Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes

Fu, Z., Gilbert, E. R., & Liu, D. (2012) · Current Diabetes Reviews · doi:10.2174/1573399811309010025 · Cited by 56 · see citing works

IAPP/amylin and β-cell failure: implication of the risk factors of type 2 diabetes

Kanatsuka, A., Kou, S., & Makino, H. (2018) · Diabetology International · doi:10.1007/s13340-018-0347-1 · Cited by 55 · see citing works

Glucose Acutely Decreases pH of Secretory Granules in Mouse Pancreatic Islets

Stiernet, P., Guiot, Y., Gilon, P., & Henquin, J.-C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513224200 · Cited by 51 · see citing works

A Critical Role for Chloride Channel-3 (CIC-3) in Smooth Muscle Cell Activation and Neointima Formation

Chu, X., Filali, M. S., Stanić, B., Takapoo, M., Sheehan, A. L., Bhalla, R. C., Lamb, F. S., & Miller, F. J. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.217604 · Cited by 51 · see citing works

Synaptotagmin VII splice variants α, β, and δ are expressed in pancreatic β‐cells and regulate insulin exocytosis

Gauthier, B. R., Duhamel, D., Iezzi, M., Theander, S. S., Saltel, F., Fukuda, M., Wehrle‐Haller, B., & Wollheim, C. B. (2007) · The FASEB Journal · doi:10.1096/fj.07-8333com · Cited by 51 · see citing works

Suppression of Sulfonylurea- and Glucose-Induced Insulin Secretion In Vitro and In Vivo in Mice Lacking the Chloride Transport Protein ClC-3

Li, D.-Q., Jing, X., Salehi, A., Collins, S. C., Hoppa, M. B., Rosengren, A. H., Zhang, E., Lundquist, I., Olofsson, C. S., Mörgelin, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.011 · Cited by 50 · see citing works

Islet-intrinsic effects of CFTR mutation

Koivula, F. N. M., McClenaghan, N. H., Harper, A. G. S., & Kelly, C. (2016) · Diabetologia · doi:10.1007/s00125-016-3936-1 · Cited by 50 · see citing works

The neuronal K+Cl− co-transporter 2 (Slc12a5) modulates insulin secretion

Kursan, S., McMillen, T. S., Beesetty, P., Dias-Junior, E., Almutairi, M. M., Sajib, A., Kozak, J. A., Aguilar-Bryan, L., & Difulvio, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-01814-0 · Cited by 34 · see citing works

Electrophysiology of Reactive Oxygen Production in Signaling Endosomes

Lamb, F. S., Moreland, J. G., & Miller, F. J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2448 · Cited by 47 · see citing works

Defining Signal Transduction by Inositol Phosphates

Shears, S. B., Ganapathi, S. B., Gokhale, N., Schenk, T. M. H., Wang, H., Weaver, J. D., Zaremba, A., & Zhou, Y. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-3015-1_13 · Cited by 46 · see citing works

Large dense-core vesicle exocytosis in pancreatic β-cells monitored by capacitance measurements

Kanno, T., Ma, X., Barg, S., Eliasson, L., Galvanovskis, J., Göpel, S., Larsson, M., Renström, E., & Rorsman, P. (2004) · Methods · doi:10.1016/j.ymeth.2004.01.003 · Cited by 44 · see citing works

The Amino Acid Transporters of the Glutamate/GABA-Glutamine Cycle and Their Impact on Insulin and Glucagon Secretion

Jenstad, M., & Chaudhry, F. A. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00199 · Cited by 44 · see citing works

Nitric oxide inhibits, and carbon monoxide activates, islet acid α-glucoside hydrolase activities in parallel with glucose-stimulated insulin secretion

Mosén, H., Salehi, A. A., Henningsson, R. N., & Lundquist, I. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06890 · Cited by 44 · see citing works

Membrane Ion Channels and Diabetes

Proks, P., & Lippiat, J. D. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206775474431 · Cited by 41 · see citing works

pH-dependent Intraluminal Organization of Mucin Granules in Live Human Mucous/Goblet Cells

Pérez-Vilar, J., Olsen, J. C., Chua, M., & Boucher, R. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413289200 · Cited by 40 · see citing works

The membrane domain of vacuolar H+ATPase: a crucial player in neurotransmitter exocytotic release

Morel, N., & Poëa‐Guyon, S. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1886-2 · Cited by 39 · see citing works

ATP-Independent Luminal Oscillations and Release of Ca2+ and H+ from Mast Cell Secretory Granules: Implications for Signal Transduction

Quesada, I., Chin, W., & Verdugo, P. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74535-4 · Cited by 39 · see citing works

Inositol 3,4,5,6-Tetrakisphosphate Inhibits Insulin Granule Acidification and Fusogenic Potential

Renström, E., Ivarsson, R., & Shears, S. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200314200 · Cited by 37 · see citing works

Imaging Docking and Fusion of Insulin Granules Induced by Antidiabetes Agents

Nagamatsu, S., Ohara‐Imaizumi, M., Nakamichi, Y., Kikuta, T., & Nishiwaki, C. (2006) · Diabetes · doi:10.2337/db06-0105 · Cited by 35 · see citing works

Calcium Dependencies of Regulated Exocytosis in Different Endocrine Cells

Dolenšek, J., Skelin, M., & Rupnik, M. S. (2011) · Physiological Research · doi:10.33549/physiolres.932176 · Cited by 35 · see citing works

cPLA2α-evoked formation of arachidonic acid and lysophospholipids is required for exocytosis in mouse pancreatic β-cells

Juhl, K., Høy, M., Olsen, H. L., Bokvist, K. B., Efanov, A. M., Hoffmann, E. K., & Gromada, J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00086.2003 · Cited by 34 · see citing works

Activation of Exchange Protein Directly Activated by Cyclic Adenosine Monophosphate and Protein Kinase A Regulate Common and Distinct Steps in Promoting Plasma Membrane Exocytic and Granule-to-Granule Fusions in Rat Islet β Cells

Kwan, E. P., Gao, X., Leung, Y. M., & Gaisano, H. Y. (2007) · Pancreas · doi:10.1097/mpa.0b013e318073d1c9 · Cited by 33 · see citing works

Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine

Chen, X., Kelly, A. C., Yates, D. T., Macko, A. R., Lynch, R. M., & Limesand, S. W. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0445 · Cited by 33 · see citing works

1α,25(OH)2 Vitamin D3 Induction of ATP Secretion in Osteoblasts

Biswas, P., & Zanello, L. P. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090306 · Cited by 33 · see citing works

cAMP modulation of Ca2+-regulated exocytosis in ACh-stimulated antral mucous cells of guinea pig

Nakahari, T., Fujiwara, S., Shimamoto, C., Kojima, K., Katsu, K., & Imai, Y. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00300.2001 · Cited by 33 · see citing works

Glucagon‐like peptide 1‐potentiated insulin secretion and proliferation of pancreatic β‐cells GLP‐1促进胰岛素分泌和胰岛β细胞增殖的机制

Ma, X., Guan, Y., & Hua, X. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12161 · Cited by 34 · see citing works

Regulation of secretory granule pH in insulin-secreting cells

Tompkins, L. S., Nullmeyer, K. D., Murphy, S. M., Weber, C. S., & Lynch, R. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.01066.2000 · Cited by 32 · see citing works

Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse islets

Ishiyama, N., Ravier, M. A., & Henquin, J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00032.2005 · Cited by 31 · see citing works

Toward Connecting Metabolism to the Exocytotic Site

Ferdaoussi, M., & MacDonald, P. E. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.10.003 · Cited by 30 · see citing works

Review: Insulin secretion: function and therapy of pancreatic beta-cells in diabetes

Rorsman, P. (2005) · The British Journal of Diabetes · doi:10.1177/14746514050050040201 · Cited by 28 · see citing works

Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues

Sun‐Wada, G., Tabata, H., Kawamura, N., Futai, M., & Wada, Y. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0421-7 · Cited by 29 · see citing works

Detection of Differential Proteomes of Human β-Cells During Islet-Like Differentiation Using iTRAQ Labeling

Jin, J., Park, J., Kim, K., KANG, Y. Y., Park, S. G., Kim, J. H., Park, K. S., Jun, H., & Kim, Y. (2009) · Journal of Proteome Research · doi:10.1021/pr800765t · Cited by 28 · see citing works

Chloride transporters and channels in β-cell physiology: revisiting a 40-year-old model

Fulvio, M. D., & Aguilar‐Bryan, L. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190513 · Cited by 28 · see citing works

Mechanisms of Exocytosis in Insulin‐Secreting B‐Cells and Glucagon‐Secreting A‐Cells

Barg, S. (2003) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2003.920102.x · Cited by 75 · see citing works

Immuno-EM of fine growth cone and synapse structures in aqueous solution using the atmospheric scanning electron microscope (ASEM)

Sato, C., Maruyama, Y., Manaka, S., Nishiyama, H., Suga, M., & Ebihara, T. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.07.257

Mechanisms of insulin exocytosis and release

Barg, S. (2001) · Lund University Publications (Lund University)

A Subset of 50 Secretory Granules in Close Contact With <scp>l</scp>-Type Ca2+ Channels Accounts for First-Phase Insulin Secretion in Mouse β-Cells

Barg, S., Eliasson, L., Renström, E., & Rorsman, P. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s74 · Cited by 227 · see citing works

Suppression of Sulfonylurea- and Glucose-Induced Insulin Secretion In Vitro and In Vivo in Mice Lacking the Chloride Transport Protein ClC-3

Li, D.-Q., Jing, X., Salehi, A., Collins, S. C., Hoppa, M. B., Rosengren, A. H., Zhang, E., Lundquist, I., Olofsson, C. S., Mörgelin, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.011 · Cited by 50 · see citing works