Cited by 155Adenosine and Purinergic SignalingNeuroinflammation and Neurodegeneration MechanismsPain Mechanisms and Treatments

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

Open access

Shiratori, Miho, Tozaki‐Saitoh, Hidetoshi, Yoshitake, Mai, Tsuda, Makoto, Inoue, Kazuhide·2010·Journal of Neurochemistry

DOI 10.1111/j.1471-4159.2010.06809.x

Open this paper in CoChat — free account Open PDF

Abstract

J. Neurochem.(2010)114, 810–819. Microglia plays an important role in many neurodegenerative conditions. ATP leaked or released by damaged cells triggers microglial activation through P2 receptors, and stimulates the release of oxygen radicals, proinflammatory cytokines and chemokines from activated microglia. However, little is known about mechanisms underlying ATP‐induced chemokine release from microglia. In this study, we found that a high concentration of ATP induces the mRNA expression and release of CXCL2 from microglia. A similar effect was observed following treatment of microglia with a P2X7 receptor (P2X7R) agonist, 2′‐and 3′‐O‐(4‐benzoylbenzoyl) ATP, and this was inhibited by pre‐treatment with a P2X7R antagonist, Brilliant Blue G. ATP induced both activation of nuclear factor of activated T cells (NFAT) and MAPKs (p38, ERK, and JNK) through P2X7R. ATP‐induced mRNA expression of CXCL2 was inhibited by INCA‐6 (an NFAT inhibitor), SB203580 (a p38 inhibitor), U0126 (a MEK‐ERK inhibitor) and JNK inhibitor II (a JNK inhibitor). However, MAPK inhibitors did not inhibit activation of NFAT. In addition, protein kinase C inhibitors suppressed ATP‐induced ERK and JNK activation, and also inhibited ATP‐induced CXCL2 expression in microglia. These results suggest that ATP increased CXCL2 production via both NFAT and protein kinase C/MAPK signaling pathways through P2X7 receptor stimulation in microglia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1471-4159.2010.06809.x

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

AP-1 function and regulation
Karin, M., Liu, Z.-G., & Zandi, E. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80068-3 · Cited by 2,904
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
Rao, A., Luo, C. H., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,592
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
Tsuda, M., Shigemoto‐Mogami, Y., Koizumi, S., Mizokoshi, A., Kohsaka, S., Salter, M. W., & Inoue, K. (2003) · Nature · doi:10.1038/nature01786 · Cited by 1,567
Self-citation
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976
Martiny‐Baron, G., Kazanietz, M. G., Mischak, H., Blumberg, P. M., Kochs, G., Hug, H., Marmé, D., & Schächtele, C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98335-3 · Cited by 1,565
Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus
Blasi, E., Barluzzi, R., Bocchini, V., Mazzolla, R., & Bistoni, F. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90073-v · Cited by 1,075
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
Chessell, I. P., Hatcher, J. P., Bountra, C., Michel, A. D., Hughes, J. P., Green, P., Egerton, J., Murfin, M., Richardson, J. C., Peck, W. L., et al. (2005) · Pain · doi:10.1016/j.pain.2005.01.002 · Cited by 807
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
Koizumi, S., Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B. V., Jacobson, K. A., Kohsaka, S., & Inoue, K. (2007) · Nature · doi:10.1038/nature05704 · Cited by 802
Self-citation
Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase
Pellegatti, P., Raffaghello, L., Bianchi, G., Piccardi, F., Pistoia, V., & Di Virgilio, F. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002599 · Cited by 668
The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4
Ho, I., Hodge, M. R., Rooney, J. W., & Glimcher, L. H. (1996) · Cell · doi:10.1016/s0092-8674(00)81299-4 · Cited by 667
Inhibition of protein kinase C μ by various inhibitors. Inhibition from protein kinase c isoenzymes
Gschwendt, M., Dieterich, S., Rennecke, J., Kittstein, W., Mueller, H.-J., & Johannes, F.-J. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00785-5 · Cited by 644
Purinergic Signalling: ATP Release
Bodin, P., & Burnstock, G. (2001) · Neurochemical Research · doi:10.1023/a:1012388618693 · Cited by 521
NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes
Rao, A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90007-8 · Cited by 512
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
Yiangou, Y., Facer, P., Durrenberger, P., Chessell, I. P., Naylor, A., Bountra, C., Banati, R. R., & Anand, P. (2006) · BMC Neurology · doi:10.1186/1471-2377-6-12 · Cited by 509
P2X7 receptor inhibition improves recovery after spinal cord injury
Wang, X., Arcuino, G., Takano, T., Lin, J. H.-C., Peng, W. G., Wan, P., Li, P., Xu, Q., Liu, Q. S., Goldman, S. A., et al. (2004) · Nature Medicine · doi:10.1038/nm1082 · Cited by 505
P2X7 Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease
Parvathenani, L. K., Tertyshnikova, S., Greco, C. R., Roberts, S. B., Robertson, B., & Posmantur, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209478200 · Cited by 488
Purinergic Modulation of Interleukin-1β Release from Microglial Cells Stimulated with Bacterial Endotoxin
Ferrari, D., Chiozzi, P., Falzoni, S., Hanau, S., & Virgilio, F. D. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.3.579 · Cited by 474
Extracellular ATP Triggers Tumor Necrosis Factor‐α Release from Rat Microglia
Hide, I., Tanaka, M., Inoue, A., Nakajima, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750965.x · Cited by 447
Self-citation
Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
Geraldes, P., Hiraoka‐Yamamoto, J., Matsumoto, M., Clermont, A. C., Leitges, M., Marette, A., Aiello, L. P., Kern, T. S., & King, G. L. (2009) · Nature Medicine · doi:10.1038/nm.2052 · Cited by 433
A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat
Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Hsieh, G. C., Zhu, C., Mikusa, J. P., Hernandez, G., Zhong, C., Gauvin, D. M., Chandran, P., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111559 · Cited by 433
Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
Peng, W., Cotrina, M. L., Han, X., Yu, H., Bekar, L. K., Blum, L., Takano, T., Tian, G.-F., Goldman, S. A., & Nedergaard, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902531106 · Cited by 425
Negative regulation of Toll-like-receptor signaling by IRF-4
Negishi, H., Ohba, Y., Yanai, H., Takaoka, A., Honma, K., Yui, K., Matsuyama, T., Taniguchi, T., & Honda, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508327102 · Cited by 412
ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.
Steinberg, T. H., Newman, A. S., Swanson, J. A., & Silverstein, S. C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47497-2 · Cited by 397
Production and Release of Neuroprotective Tumor Necrosis Factor by P2X7Receptor-Activated Microglia
Suzuki, T., Hide, I., Ido, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3792-03.2004 · Cited by 394
Self-citation
Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway
Chow, C.-W., Rincón, M., Cavanagh, J., Dickens, M., & Davis, R. J. (1997) · Science · doi:10.1126/science.278.5343.1638 · Cited by 357
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca 2+ signals across the inner ear
Anselmi, F., Hernández, V. H., Crispino, G., Seydel, A., Ortolano, S., Roper, S. D., Kessaris, N., Richardson, W. D., Rickheit, G., Filippov, M. A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800793105 · Cited by 342
Microglial activation by purines and pyrimidines
Inoue, K. (2002) · Glia · doi:10.1002/glia.10150 · Cited by 313
Self-citation
The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation
Dean, J. L. E., Sully, G., Clark, A. R., & Saklatvala, J. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.04.006 · Cited by 312
A Novel Recombinant Plasma Membrane-targeted Luciferase Reveals a New Pathway for ATP Secretion
Pellegatti, P., Falzoni, S., Pinton, P., Rizzuto, R., & Virgilio, F. D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-03-0222 · Cited by 296
Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase
Beigi, R. D., Kobatake, E., Aizawa, M., & Dubyak, G. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.1.c267 · Cited by 296
Activation of Microglia by Amyloid β Requires P2X7 Receptor Expression
Sanz, J. M., Chiozzi, P., Ferrari, D., Colaianna, M., Idzko, M., Falzoni, S., Fellin, R., Trabace, L., & Di Virgilio, F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803612 · Cited by 293
Extracellular ATP Activates Transcription Factor NF-κB through the P2Z Purinoreceptor by Selectively Targeting NF-κB p65 (RelA)
Ferrari, D., Wesselborg, S., Bauer, M. K. A., & Schulze‐Osthoff, K. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.7.1635 · Cited by 286
Upregulated Expression of Purinergic P2X 7 Receptor in Alzheimer Disease and Amyloid-β Peptide-Treated Microglia and in Peptide-Injected Rat Hippocampus
McLarnon, J. G., Ryu, J. K., Walker, D. G., & Choi, H. B. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240470.97295.d3 · Cited by 281
P2Y12Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury
Tozaki‐Saitoh, H., Tsuda, M., Miyata, H., Ueda, K., Kohsaka, S., & Inoue, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-08.2008 · Cited by 279
Self-citation
Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines
Widmer, U., Manogue, K. R., Cerami, A., & Sherry, B. A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.11.4996 · Cited by 251
P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system
James, G., & Butt, A. M. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01756-9 · Cited by 236
Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha
Tessier, P. A., Naccache, P. H., Clark‐Lewis, I., Gladue, R. P., Neote, K. S., & McColl, S. R. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.7.3595 · Cited by 233
P2X7Receptor Expression after Ischemia in the Cerebral Cortex of Rats
Franke, H., Günther, A., Grosche, J., Schmidt, R., Roßner, S., Reinhardt, R., Faber‐Zuschratter, H., Schneider, D., & Illés, P. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.7.686 · Cited by 227
The role of cell cycle‐mediated events in Alzheimer's disease
Raina, A. K., Monteiro, M. J., McShea, A., & Smith, M. A. (1999) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1999.00106.x · Cited by 224
Integration of calcineurin and MEF2 signals by the coactivator p300 during T‐cell apoptosis
Youn, H., Chatila, T. A., & Liu, J. O. (2000) · The EMBO Journal · doi:10.1093/emboj/19.16.4323 · Cited by 223
Activation and Deactivation of Gene Expression by Ca2+/Calcineurin-NFAT-mediated Signaling
Im, S., & Rao, A. (2004) · Molecules and Cells · doi:10.1016/s1016-8478(23)13074-3 · Cited by 212
SAPK/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor
Humphreys, B. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002770200 · Cited by 199
Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms.
Greenberg, S., Virgilio, F. D., Steinberg, T. H., & Silverstein, S. C. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81521-1 · Cited by 192
2-deoxy-d-glucose protects hippocampal neurons against excitotoxic and oxidative injury: Evidence for the involvement of stress proteins
Lee, J., Bruce‐Keller, A. J., Kruman, Y., Chan, S. L., & Mattson, M. P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990701)57:1 · Cited by 179
Selective inhibition of calcineurin-NFAT signaling by blocking protein–protein interaction with small organic molecules
Roehrl, M. H. A., Kang, S., Aramburu, J., Wagner, G., Rao, A., & Hogan, P. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401835101 · Cited by 177
The AU-Rich Transcriptome: More Than Interferons and Cytokines, and Its Role in Disease
Khabar, K. S. A. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.1 · Cited by 176
Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases
Yang, T. T. C., Xiong, Q., Enslen, H., Davis, R. J., & Chow, C.-W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3892-3904.2002 · Cited by 174
Mechanisms underlying extracellular ATP‐evoked interleukin‐6 release in mouse microglial cell line, MG‐5
Shigemoto‐Mogami, Y., Koizumi, S., Tsuda, M., Ohsawa, K., Kohsaka, S., & Inoue, K. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00514.x · Cited by 173
Self-citation
μ and κ Opioid Receptors Activate ERK/MAPK via Different Protein Kinase C Isoforms and Secondary Messengers in Astrocytes
Belcheva, M. M., Clark, A. L., Haas, P. D., Serna, J. S., Hahn, J. W., Kiss, A., & Coscia, C. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502593200 · Cited by 173
Upregulation of the Enzyme Chain Hydrolyzing Extracellular ATP after Transient Forebrain Ischemia in the Rat
Braun, N., Zhu, Y. S., Krieglstein, J., Culmsee, C., & Zimmermann, H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-13-04891.1998 · Cited by 172
Stress-activated Protein Kinase/JNK Activation and Apoptotic Induction by the Macrophage P2X7 Nucleotide Receptor
Humphreys, B. D., Rice, J., Kertesy, S. B., & Dubyak, G. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61445-6 · Cited by 170
Multiple p21ras effector pathways regulate nuclear factor of activated T cells.
Genot, E. M., Cleverley, S., Henning, S. W., & Cantrell, D. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00766.x · Cited by 164
P2X7/P2Z Purinoreceptor-mediated Activation of Transcription Factor NFAT in Microglial Cells
Ferrari, D., Stroh, C., & Schulze‐Osthoff, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13205 · Cited by 156
Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization
Porter, C. M., Havens, M. A., & Clipstone, N. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3543 · Cited by 151
Identification of Elastase as a Secretory Protease from Cultured Rat Microglia
Nakajima, K., Shimojo, M., Hamanoue, M., Ishiura, S., Sugita, H., & Kohsaka, S. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb11356.x · Cited by 139
Neutralization of Macrophage Inflammatory Protein 2 (MIP-2) and MIP-1α Attenuates Neutrophil Recruitment in the Central Nervous System during Experimental Bacterial Meningitis
Diab, A., Abdalla, H., Li, H. L., Shi, F., Zhu, J., Höjberg, B., Lindquist, L., Wretlind, B., Bakhiet, M., & Link, H. (1999) · Infection and Immunity · doi:10.1128/iai.67.5.2590-2601.1999 · Cited by 139
Peripheral blood stem cell mobilization: The CXCR2 ligand GROβ rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties
Pelus, L. M., & Fukuda, S. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.04.004 · Cited by 127
Role of P2X 7 Receptors in Ischemic and Excitotoxic Brain Injury In Vivo
Feuvre, R. A. L., Brough, D., Touzani, O., & Rothwell, N. J. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048519.34839.97 · Cited by 122
Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT
Kataoka, A., Tozaki‐Saitoh, H., Koga, Y., Tsuda, M., & Inoue, K. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05744.x · Cited by 121
Self-citation
Inhibition of CXCR2 signaling promotes recovery in models of multiple sclerosis
Kerstetter, A. E., Padovani-Claudio, D. A., Bai, L., & Miller, R. H. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.010 · Cited by 100
P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C
BRADFORD, M. D., & Soltoff, S. P. (2002) · Biochemical Journal · doi:10.1042/bj20020358 · Cited by 97
Characterization and possible function of adenosine 5′‐triphosphate receptors in activated rat microglia
Nörenberg, W., Langosch, J. M., Gebicke‐Haerter, P. J., & Illés, P. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14830.x · Cited by 96
Differential regulation of the CXCR2 chemokine network in rat brain trauma: Implications for neuroimmune interactions and neuronal survival
Vallès, A., Grijpink-Ongering, L. G., de Bree, F. M., Tuinstra, T., & Ronken, E. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.015 · Cited by 95
c-Jun N-terminal Kinase (JNK) Positively Regulates NFATc2 Transactivation through Phosphorylation within the N-terminal Regulatory Domain
Ortega‐Pérez, I., Cano, E., Were, F., Villar, M., Vázquez, J., & Redondo, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501898200 · Cited by 79
CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer
Parenty, G., Appelbe, S., & Milligan, G. (2008) · Biochemical Journal · doi:10.1042/bj20071689 · Cited by 75
NF-κB and c-Jun-dependent regulation of macrophage inflammatory protein-2 gene expression in response to lipopolysaccharide in RAW 264.7 cells
Kim, D., Han, J. H., & Kwon, H. (2003) · Molecular Immunology · doi:10.1016/j.molimm.2003.07.001 · Cited by 72
Modulation of monocyte signaling and pore formation in response to agonists of the nucleotide receptor P2X7
Aga, M., Johnson, C. J., Hart, A. P., Guadarrama, A. G., Suresh, M., Svaren, J. P., Bertics, P. J., & Darien, B. J. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.1.222 · Cited by 72
Macrophage Inflammatory Protein-2 and KC Induce Chemokine Production by Mouse Astrocytes
Luo, Y., Fischer, F. R., Hancock, W. W., & Dorf, M. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.4015 · Cited by 67
Purinergic receptors modulate MAP kinases and transcription factors that control microglial inflammatory gene expression
Potucek, Y., Crain, J. M., & Watters, J. J. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.04.005 · Cited by 61
Transcription Cooperation by NFAT·C/EBP Composite Enhancer Complex
Yang, T. T. C., & Chow, C.-W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211560200 · Cited by 57
Accumulation of microglial cells expressing ELR motif-positive CXC chemokines and their receptor CXCR2 in monkey hippocampus after ischemia-reperfusion
Popivanova, B. K., Koike, K., Tonchev, A. B., Ishida, Y., Kondo, T., Ogawa, S., Mukaida, N., Inoue, M., & Yamashima, T. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02343-6 · Cited by 51
MafA transcription factor is phosphorylated by p38 MAP kinase
Sii-Felice, K., Pouponnot, C., Gillet, S., Lecoin, L., Girault, J., Eychène, A., & Felder‐Schmittbuhl, M. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.04.086 · Cited by 48
Chemokine MIP-2/CXCL2, acting on CXCR2, induces motor neuron death in primary cultures
De Paola, M., Buanne, P., Biordi, L., Bertini, R., Ghezzi, P., & Mennini, T. (2007) · NeuroImmunoModulation · doi:10.1159/000123834 · Cited by 47 · cited 1×
“…reports indicate that CXCR2 is involved in Alzheimer’s disease (Bakshi et al. 2009), ischemia (Popivanova et al. 2003), traumatic injury (Valles et al. 2006), multiple sclerosis (Kerstetter et al. 2009), neuronal death (De Paola et al. 2007) and opioid receptor function (Parenty et al. 2008).”
Role of PKC-δ on substance P-induced chemokine synthesis in pancreatic acinar cells
Ramnath, R. D., Sun, J. T., Adhikari, S., Liang, Z., & Bhatia, M. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00360.2007 · Cited by 34
Identification of protein kinase C isoforms involved in interferon-gamma-induced expression of inducible nitric oxide synthase in murine BV2 microglia
Kang, J., Yang, M.-S., Jou, I., & Joe, E.-H. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01515-4 · Cited by 27
Structural optimization of a CXCR2-directed antagonist that indirectly inhibits γ-secretase and reduces Aβ
Bakshi, P., Jin, C., Broutin, P., Berhane, B. T., Reed, J. M., & MULLAN, M. J. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.09.051 · Cited by 22
Analysis of the mechanism regulating the stability of rat macrophage inflammatory protein‐2 mRNA in RBL‐2H3 cells
Numahata, K., Komagata, T., Hirasawa, N., Someya, K., Xiao, Y., & Ohuchi, K. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10710 · Cited by 14
Microglial ecto-Ca2+-ATPase activity in a rat model of focal homologous blood clot embolic cerebral ischemia: an enzyme histochemical study
Igarashi, H., Yokofujita, J., Murakami, K., Okada, A., & Kuroda, M. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00028-5 · Cited by 7

Sorted by citations

Physiology of Microglia
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
Gong, T., Liu, L., Jiang, W., & Zhou, R. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0215-7 · Cited by 1,672
The P2X7 Receptor in Infection and Inflammation
Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267
“…and mouse mast cells (Panenka et al., 2001; Kurashima et al., 2012), IL-8 in rat C6 glioma cells (Wei et al., 2008), CC-chemokine ligand 3 (CCL3) in mouse microglial MG-5 cells (Kataoka et al., 2009), and CXCL2 in mouse microglia and mast cells (Shiratori et al., 2010; Kurashima et al., 2012).”
The biphasic function of microglia in ischemic stroke
Ma, Y., Wang, J., Wang, Y., & Yang, G.-Y. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.005 · Cited by 655
“Culture supernatants derived from Th1 cells promoted microglia to up-regulate M1 phenotype related genes such as MCP-1 and CCL-2 expression, indicating that Th1 could affect microglia polarization in a paracrine manner.”
Influential
The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases
Nakahira, K., Hisata, S., & Choi, A. M. K. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6407 · Cited by 363

See all 155

Authors: Shiratori, M., Tozaki‐Saitoh, H., Yoshitake, M., Tsuda, M., & Inoue, K.
Affiliations: Kyushu University (JP)
Corresponding author: Inoue, Kazuhide
ORCID: Tozaki‐Saitoh, Hidetoshi
Tsuda, Makoto
Inoue, Kazuhide
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2010-07-06
Volume: 114
Issue: 3
Pages: 810-819
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/j.1471-4159.2010.06809.x
OpenAlex: W1575476617
Cited by: 153
References: 77
Citations by year: 2026: 3 · 2025: 9 · 2024: 8 · 2023: 11 · 2022: 11 · 2021: 9 · 2020: 12 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 13 · 2015: 11 · 2014: 13 · 2013: 6 · 2012: 14
FWCI: 5.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: P2X7 receptor, microglia, CXCL2, chemokine secretion, ATP, NFAT, MAPK signaling, protein kinase C, p38 MAPK, ERK, JNK, Brilliant Blue G, neuroinflammation, neurodegeneration
MeSH terms: Adenosine Triphosphate, Animals, Cell Line, Protein Kinase C, Up-Regulation, Microglia, Receptors, Purinergic P2, MAP Kinase Signaling System, NFATC Transcription Factors, Mice, Rats, Chemokine CXCL2, Receptors, Purinergic P2X7, Purinergic P2 Receptor Agonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks