The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Bifidobacterium and Lactobacillus DNA in the human placenta
Abstract
AIMS: Bifidobacteria and lactobacilli are part of the human normal intestinal microbiota and may possibly be transferred to the placenta. It was hypothesized that intestinal bacteria or their components are present in the placenta and that the foetus may be exposed to them. We investigated the presence of bifidobacteria and lactobacilli and their DNA in the human placenta. METHODS AND RESULTS: We studied 34 human placentae (25 vaginal and nine caesarean deliveries) for the presence Bifidobacterium spp. and Lactobacillus rhamnosus. Cultivation was used for the detection of viable cells and genus and species-specific PCR for the detection of DNA. No bifidobacteria or lactobacilli were found by cultivation. Bifidobacterial DNA was detected in 33 and L. rhamnosus DNA in 31 placenta samples. CONCLUSIONS: DNA from intestinal bacteria was found in most placenta samples. The results suggest that horizontal transfer of bacterial DNA from mother to foetus may occur via placenta. SIGNIFICANCE AND IMPACT OF THE STUDY: Bacterial DNA contains unmethylated CpG oligodeoxynucleotide motifs which induce immune effects. Specific CpG motifs activate Toll-like receptor 9 and subsequently trigger Th-1-type immune responses. Although the newborn infant is considered immunologically immature, exposure by bacterial DNA may programme the infant's immune development during foetal life earlier than previously considered.
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Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 3×
“Specific CpG oligodeoxynucleotide motifs present in the bacterial DNA exert immunostimulatory effects through activation of Toll-like receptor 9 and subsequent triggering of Th-1-type immune responses (Hemmi et al. 2000; Krieg 2002; Yu et al. 2007).”
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Cited by
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950
An insight into gut microbiota and its functionalities
Adak, A., & Khan, M. R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2943-4 · Cited by 1,485
The microbiome in early life: Implications for health outcomes
Tamburini, S., Shen, N., Wu, H. C., & Clemente, J. C. (2016) · Nature Medicine · doi:10.1038/nm.4142 · Cited by 1,213
Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096
Microbiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089
Metadata
- Authors
- Satokari, R., Grönroos, T., Laitinen, K., Salminen, S., & Isolauri, E.
- Venue
- Letters in Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01
- Volume
- 48
- Issue
- 1
- Pages
- 8-12
- ISSN
- 0266-8254 (ISSN-L)
- 1472-765X
- OpenAlex
- W1999537838
- Cited by
- 303
- References
- 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Satokari, R., Grönroos, T., Laitinen, K., Salminen, S., & Isolauri, E. (2009). Bifidobacterium and Lactobacillus DNA in the human placenta. Letters in Applied Microbiology. https://doi.org/10.1111/j.1472-765x.2008.02475.x
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