An insight into gut microbiota and its functionalities

DNA sequencing with chain-terminating inhibitors

Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572 · see citing works

Pathogen Recognition and Innate Immunity

Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,974 · see citing works

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

Diversity of the Human Intestinal Microbial Flora

Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works

Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics

Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works

Enterotypes of the human gut microbiome

MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works

Changes of Intestinal Functions in Liver Cirrhosis

Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works

Linking long-term dietary patterns with gut microbial enterotypes

Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works

The carbohydrate-active enzymes database (CAZy) in 2013

Lombard, V., Ramulu, H. G., Drula, É., Coutinho, P. M., & Henrissat, B. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1178 · Cited by 6,355 · see citing works

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works

Diversity, stability and resilience of the human gut microbiota

Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533 · see citing works

Host-Bacterial Mutualism in the Human Intestine

Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · see citing works

Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works

Richness of human gut microbiome correlates with metabolic markers

Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works

Phylogenetic structure of the prokaryotic domain: The primary kingdoms

Woese, C. R., & Fox, G. E. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.5088 · Cited by 4,131 · see citing works

Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781 · see citing works

Gut microbiota, metabolites and host immunity

Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works

Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine

Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358 · see citing works

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315 · see citing works

Human Genetics Shape the Gut Microbiome

Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164 · see citing works

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058 · see citing works

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

Wahlstrom, A. M., Sayin, S. I., Marschall, H., & Bäckhed, F. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.005 · Cited by 2,903 · see citing works

Environment dominates over host genetics in shaping human gut microbiota

Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., et al. (2018) · Nature · doi:10.1038/nature25973 · Cited by 2,859 · see citing works

Energy contributions of volatile fatty acids from the gastrointestinal tract in various species

Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750 · see citing works

Influence of diet on the gut microbiome and implications for human health

Singh, R. K., Chang, H.-W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1175-y · Cited by 2,599 · see citing works

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554 · see citing works

The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.

(2015) · PubMed Central · Cited by 2,540 · see citing works

Succession of microbial consortia in the developing infant gut microbiome

Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000081107 · Cited by 2,540 · see citing works

Health benefits of dietary fiber

Anderson, J. W., Baird, P., Davis Jr, R. H., Ferreri, S., Knudtson, M., Koraym, A., Waters, V., & Williams, C. L. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00189.x · Cited by 2,239 · see citing works

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200 · see citing works

Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine

Louis, P., & Flint, H. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01514.x · Cited by 2,179 · see citing works

An integrated catalog of reference genes in the human gut microbiome

MetaHIT Consortium, Li, J., Jia, H., Cai, X., Zhong, H., Feng, Q., Sunagawa, S., Arumugam, M., Kultima, J. R., Prifti, E., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2942 · Cited by 2,164 · see citing works

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

MetaHIT consortium, Forslund, K., Hildebrand, F., Nielsen, T., Falony, G., Le Chatelier, E., Sunagawa, S., Prifti, E., Vieira-Silva, S., Gudmundsdottir, V., et al. (2015) · Nature · doi:10.1038/nature15766 · Cited by 2,116 · see citing works

The NIH Human Microbiome ProjectPreprint

The NIH HMP Working Group, Peterson, J. L., Garges, S., Giovanni, M. Y., McInnes, P., Wang, L., Schloss, J. A., Bonazzi, V. R., McEwen, J. E., Wetterstrand, K. A., et al. (2009) · Genome Research · doi:10.1101/gr.096651.109 · Cited by 2,092 · see citing works

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works

The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon

Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003 · see citing works

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904 · see citing works

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,776 · see citing works

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770 · see citing works

The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755 · see citing works

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database

Rawlings, N. D., Barrett, A. J., Thomas, P. D., Huang, X., Bateman, A., & Finn, R. D. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1134 · Cited by 1,749 · see citing works

H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE

Hooper, L. V., Midtvedt, T., & Gordon, J. I. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.011602.092259 · Cited by 1,623 · see citing works

Comparison of Next-Generation Sequencing Systems

Liu, L., Li, Y., Li, S., Hu, N., He, Y., Pong, R., Lin, D., Lü, L., & Law, M. (2012) · BioMed Research International · doi:10.1155/2012/251364 · Cited by 1,605 · see citing works

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584 · see citing works

Symbiotic bacteria direct expression of an intestinal bactericidal lectin

Cash, H. L., Whitham, C. V., Behrendt, C. L., & Hooper, L. V. (2006) · Science · doi:10.1126/science.1127119 · Cited by 1,432 · see citing works

Targeting bile‐acid signalling for metabolic diseases

Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., & Schoonjans, K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2619 · Cited by 1,422 · see citing works

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364 · see citing works

A Genomic View of the Human- <i>Bacteroides thetaiotaomicron</i> Symbiosis

Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science · doi:10.1126/science.1080029 · Cited by 1,353 · see citing works

Principles and clinical implications of the brain-gut-enteric microbiota axis

Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

Chamaillard, M., Hashimoto, M., Horie, Y., Masumoto, J., Qiu, S., Saab, L., Ogura, Y., Kawasaki, A., Fukase, K., Kusumoto, S., et al. (2003) · Nature Immunology · doi:10.1038/ni945 · Cited by 1,323 · see citing works

Gut microbiome of the Hadza hunter-gatherers

Schnorr, S. L., Candela, M., Rampelli, S., Centanni, M., Consolandi, C., Basaglia, G., Turroni, S., Biagi, E., Peano, C., Severgnini, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4654 · Cited by 1,317 · see citing works

Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation

Browne, H. P., Forster, S. C., Anonye, B. O., Kumar, N., Neville, B. A., Stares, M. D., Goulding, D., & Lawley, T. D. (2016) · Nature · doi:10.1038/nature17645 · Cited by 1,299 · see citing works

The intestinal epithelial barrier: a therapeutic target?

Odenwald, M. A., & Turner, J. R. (2017) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2016.169 · Cited by 1,288 · see citing works

Stability criteria for complex ecosystems

Allesina, S., & Tang, S. (2012) · Nature · doi:10.1038/nature10832 · Cited by 1,232 · see citing works

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2

Ulluwishewa, D., Anderson, R. C., McNabb, W. C., Moughan, P. J., Wells, J. M., & Roy, N. C. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135657 · Cited by 1,177 · see citing works

Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota

Hehemann, J.-H., Correc, G., Barbeyron, T., Helbert, W., Czjzek, M., & Michel, G. (2010) · Nature · doi:10.1038/nature08937 · Cited by 1,117 · see citing works

A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096 · see citing works

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,076 · see citing works

Psychobiotics and the manipulation of bacteria–gut–brain signals

Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. W. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.002 · Cited by 1,068 · see citing works

Akkermansia muciniphila and its role in regulating host functions

Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044 · see citing works

Gut Microbiota and Extreme Longevity

Biagi, E., Franceschi, C., Rampelli, S., Severgnini, M., Ostan, R., Turroni, S., Consolandi, C., Quercia, S., Scurti, M., Monti, D., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.016 · Cited by 1,025 · see citing works

Inflammaging and ‘Garb-aging’

Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997 · see citing works

Fat, fibre and cancer risk in African Americans and rural Africans

O’Keefe, S. J. D., Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J. M., Kinross, J., Wahl, E., Ruder, E., et al. (2015) · Nature Communications · doi:10.1038/ncomms7342 · Cited by 982 · see citing works

Untitled work

(1958) · PubMed · Cited by 978 · see citing works

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946 · see citing works

Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces

Duncan, S. H., Belenguer, A., Holtrop, G., Johnstone, A. M., Flint, H. J., & Lobley, G. E. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02340-06 · Cited by 941 · see citing works

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

Harach, T., Marungruang, N., Duthilleul, N., Cheatham, V., Mc Coy, K. D., Frisoni, G., Neher, J. J., Fåk, F., Jucker, M., Lasser, T., et al. (2017) · Scientific Reports · doi:10.1038/srep41802 · Cited by 901 · see citing works

The Rebirth of Culture in Microbiology through the Example of Culturomics To Study Human Gut Microbiota

Lagier, J., Hugon, P., Khelaifia, S., Fournier, P., Scola, B. L., & Raoult, D. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-14 · Cited by 839 · see citing works

Gut Microbiota Orchestrates Energy Homeostasis during Cold

Chevalier, C., Stojanović, O., Colin, D. J., Suarez-Zamorano, N., Tarallo, V., Veyrat-Durebex, C., Rigo, D., Fabbiano, S., Stevanović, A., Hagemann, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.004 · Cited by 829 · see citing works

Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: a pilot study in patients with irritable bowel syndrome

Pinto-Sanchez, M. I., Hall, G. B., Ghajar, K., Nardelli, A., Bolino, C., Lau, J. T., Martin, F.-P., Cominetti, O., Welsh, C., Rieder, A., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.05.003 · Cited by 821 · see citing works

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 816 · see citing works

Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases

Lee, S. H. (2015) · Intestinal Research · doi:10.5217/ir.2015.13.1.11 · Cited by 810 · see citing works

Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties

Marín, L., Miguélez, E. M., Villar, C. J., & Lombó, F. (2015) · BioMed Research International · doi:10.1155/2015/905215 · Cited by 778 · see citing works

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- <i>N</i> -Oxide

Romano, K. A., Vivas, E. I., Amador-Noguez, D., & Rey, F. E. (2015) · mBio · doi:10.1128/mbio.02481-14 · Cited by 777 · see citing works

Moving towards individualized medicine with pharmacogenomics

Evans, W. E., & Relling, M. V. (2004) · Nature · doi:10.1038/nature02626 · Cited by 772 · see citing works

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R., & Nicholson, J. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904489106 · Cited by 765 · see citing works

Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo, T., & Fagarasan, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307317101 · Cited by 721 · see citing works

A Metagenomic Approach to Characterization of the Vaginal Microbiome Signature in Pregnancy

Aagaard, K. M., Riehle, K. P., Ma, J., Segata, N., Mistretta, T., Coarfa, C., Raza, S., Rosenbaum, S., den Veyver, I. B. V., Milosavljevic, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036466 · Cited by 714 · see citing works

Gut microbiome interactions with drug metabolism, efficacy, and toxicity

Wilson, I. D., & Nicholson, J. K. (2017) · Translational Research · doi:10.1016/j.trsl.2016.08.002 · Cited by 656 · see citing works

Should we standardize the 1,700-year-old fecal microbiota transplantation?

Zhang, F., Luo, W., Shi, Y., Fan, Z., & Ji, G. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.251 · Cited by 619 · see citing works

Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats

Zhang, X., Zhao, Y., Zhang, M., Pang, X., Xu, J., Kang, C., Li, M., Zhang, C., Zhang, Z., Zhang, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042529 · Cited by 615 · see citing works

Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition

Charbonneau, M. R., O’Donnell, D., Blanton, L. V., Totten, S. M., Davis, J. C. C., Barratt, M. J., Cheng, J., Guruge, J., Talcott, M., Bain, J. R., et al. (2016) · Cell · doi:10.1016/j.cell.2016.01.024 · Cited by 606 · see citing works

Compositional and Functional Features of the Gastrointestinal Microbiome and Their Effects on Human Health

Hollister, E. B., Gao, C., & Versalovic, J. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.052 · Cited by 533 · see citing works

Diversity of Bacterial Populations on the Tongue Dorsa of Patients with Halitosis and Healthy Patients

Kazor, C. E., Mitchell, P. M., Lee, A. M., Stokes, L. N., Loesche, W. J., Dewhirst, F. E., & Paster, B. J. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.2.558-563.2003 · Cited by 533 · see citing works

A randomized synbiotic trial to prevent sepsis among infants in rural India

Panigrahi, P., Parida, S., Nanda, N. C., Satpathy, R., Pradhan, L., Chandel, D. S., Baccaglini, L., Mohapatra, A., Mohapatra, S. S., Misra, P. R., et al. (2017) · Nature · doi:10.1038/nature23480 · Cited by 526 · see citing works

Infectious History

Lederberg, J. (2000) · Science · doi:10.1126/science.288.5464.287 · Cited by 523 · see citing works

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

Wu, W. H., Sun, M., Chen, F., Cao, A., Liu, H., Zhao, Y., Huang, X., Xiao, Y., Yao, S., Zhao, Q., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.114 · Cited by 500 · see citing works

Microbes Drive Evolution of Animals and Plants: the Hologenome Concept

ROSENBERG, E. B., & Zilber‐Rosenberg, I. (2016) · mBio · doi:10.1128/mbio.01395-15 · Cited by 499 · see citing works

Influence of high-fat diet on gut microbiota

Murphy, E. A., Velázquez, K. T., & Herbert, K. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000209 · Cited by 495 · see citing works

Interactions between gut bacteria and bile in health and disease

Long, S. L., Gahan, C. G. M., & Joyce, S. A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.06.002 · Cited by 495 · see citing works

Emerging technologies in DNA sequencingPreprint

Metzker, M. L. (2005) · Genome Research · doi:10.1101/gr.3770505 · Cited by 493 · see citing works

Moonlighting proteins: old proteins learning new tricks

Jeffery, C. J. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00167-7 · Cited by 475 · see citing works

Gut microbiota: a potential new territory for drug targeting

Jia, W. P., Li, H., Zhao, L., & Nicholson, J. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2505 · Cited by 471 · see citing works

Association of host genome with intestinal microbial composition in a large healthy cohort

GEM Project Research Consortium, Turpin, W., Espin-Garcia, O., Xu, W., Silverberg, M. S., Kevans, D., Smith, M. I., Guttman, D. S., Griffiths, A., Panaccione, R., et al. (2016) · Nature Genetics · doi:10.1038/ng.3693 · Cited by 460 · see citing works

A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities

Zhang, J., Guo, Z., Xue, Z., Sun, Z., Zhang, M., Wang, L., Wang, G., Wang, F., Xu, J., Cao, H., et al. (2015) · The ISME Journal · doi:10.1038/ismej.2015.11 · Cited by 458 · see citing works

Helicobacter pylori moves through mucus by reducing mucin viscoelasticity

Celli, J. P., Turner, B. S., Afdhal, N. H., Keates, S. E., Ghiran, I. C., Kelly, C. P., Ewoldt, R. H., McKinley, G. H., So, P. T. C., Erramilli, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903438106 · Cited by 456 · see citing works

Gut Microbiotas and Host Evolution: Scaling Up Symbiosis

Shapira, M. (2016) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2016.03.006 · Cited by 449 · see citing works

Diagnosis and Treatment ofClostridium difficilein Adults

Bagdasarian, N., Rao, K. K., & Malani, P. (2015) · JAMA · doi:10.1001/jama.2014.17103 · Cited by 445 · see citing works

INTESTINAL CROSSTALK

Clark, J. A., & Coopersmith, C. M. (2007) · Shock · doi:10.1097/shk.0b013e31805569df · Cited by 443 · see citing works

Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula

Xu, J. Y., Lian, F., Zhao, L., Zhao, Y., Chen, X., Zhang, X., Guo, Y., Zhang, C., Zhou, Q., Xue, Z., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.177 · Cited by 423 · see citing works

Inactivation of Digoxin by the Gut Flora: Reversal by Antibiotic Therapy

Lindenbaum, J., Rund, D. G., Butler, V. P., Tse-Eng, D., & Saha, J. R. (1981) · New England Journal of Medicine · doi:10.1056/nejm198110013051403 · Cited by 423 · see citing works

Microbiota transplantation restores normal fecal bile acid composition in recurrent<i>Clostridium difficile</i>infection

Weingarden, A. R., Chen, C., Bobr, A., Yao, D., Lu, Y., Nelson, V. M., Sadowsky, M. J., & Khoruts, A. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00282.2013 · Cited by 423 · see citing works

Metagenome Sequencing of the Hadza Hunter-Gatherer Gut Microbiota

Rampelli, S., Schnorr, S. L., Consolandi, C., Turroni, S., Severgnini, M., Peano, C., Brigidi, P., Crittenden, A. N., Henry, A. G., & Candela, M. (2015) · Current Biology · doi:10.1016/j.cub.2015.04.055 · Cited by 399 · see citing works

Rethinking “Enterotypes”

Knights, D., Ward, T. L., McKinlay, C. E., Miller, H., Gonzalez, A., McDonald, D., & Knight, R. (2014) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2014.09.013 · Cited by 396 · see citing works

Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT

Barichella, M., Pacchetti, C., Bolliri, C., Cassani, E., Iorio, L., Pusani, C., Pinelli, G., Privitera, G., Cesari, I., Faierman, S. A., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003127 · Cited by 390 · see citing works

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

Boneca, I. G., Dussurget, O., Cabanes, D., Nahori, M., Sousa, S., Lecuit, M., Psylinakis, E., Bouriotis, V., Hugot, J., Giovannini, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609672104 · Cited by 378 · see citing works

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S. G., Patterson, A. D., & Perdew, G. H. (2015) · Scientific Reports · doi:10.1038/srep12689 · Cited by 377 · see citing works

Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine

Savignac, H. M., Corona, G., Mills, H., Chen, L., Spencer, J. P. E., Tzortzis, G., & Burnet, P. W. J. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.10.006 · Cited by 377 · see citing works

Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy

Kau, A. L., Planer, J. D., Liu, J., Rao, S. M., Yatsunenko, T., Trehan, I., MANARY, M. J., Liu, T., Stappenbeck, T. S., Maleta, K. M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa4877 · Cited by 373 · see citing works

Gut microbiota role in dietary protein metabolism and health-related outcomes: The two sides of the coin

Portune, K. J., Beaumont, M., Davila, A.-M., Tomé, D., Blachier, F., & Sanz, Y. (2016) · Trends in Food Science &amp; Technology · doi:10.1016/j.tifs.2016.08.011 · Cited by 356 · see citing works

Microbial Genetic Composition Tunes Host Longevity

Han, B., Sivaramakrishnan, P., Lin, C.-C., Neve, I. A. A., He, J., Tay, L. W. R., Sowa, J. N., Sizovs, A., Du, G., Wang, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.036 · Cited by 353 · see citing works

Effect of probiotics on central nervous system functions in animals and humans: a systematic review

Wang, H., Lee, I.-S., Braun, C., & Enck, P. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16018 · Cited by 334 · see citing works

No Vacancy: How Beneficial Microbes Cooperate with Immunity To Provide Colonization Resistance to Pathogens

Sassone‐Corsi, M., & Raffatellu, M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403169 · Cited by 330 · see citing works

The effects of probiotics in lactose intolerance: A systematic review

Oak, S. J., & Jha, R. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1425977 · Cited by 318 · see citing works

Commensal bacteria and essential amino acids control food choice behavior and reproduction

Leitão-Gonçalves, R., Carvalho-Santos, Z., Francisco, A. P., Fioreze, G. T., Anjos, M., Baltazar, C., Elias, A. P., Itskov, P. M., Piper, M. D. W., & Ribeiro, C. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2000862 · Cited by 315 · see citing works

Bifidobacterium and Lactobacillus DNA in the human placenta

Satokari, R. M., Grönroos, T., Laitinen, K., Salminen, S., & Isolauri, E. (2008) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2008.02475.x · Cited by 304 · see citing works

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.077 · Cited by 291 · see citing works

Dietary sialic acid supplementation improves learning and memory in piglets

Wang, B., Yu, B., Karim, M., Hu, H., Sun, Y. W., McGreevy, P. D., Petocz, P., Held, S. D. E., & Brand-Miller, J. C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.561 · Cited by 288 · see citing works

Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome

Labus, J. S., Hollister, E. B., Jacobs, J., Kirbach, K., Oezguen, N., Gupta, A., Acosta, J., Luna, R. A., Aagaard, K., Versalovic, J., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0260-z · Cited by 284 · see citing works

Secretor Genotype (FUT2 gene) Is Strongly Associated with the Composition of Bifidobacteria in the Human Intestine

Wacklin, P., Mäkivuokko, H., Alakulppi, N. S., Nikkilä, J., Tenkanen, H., Räbinä, J., Partanen, J., Aranko, K., & Mättö, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020113 · Cited by 283 · see citing works

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice

Kibe, R., Kurihara, S., Sakai, Y., Suzuki, H., Ooga, T., Sawaki, E., Muramatsu, K., Nakamura, A., Yamashita, A., Kitada, Y., et al. (2014) · Scientific Reports · doi:10.1038/srep04548 · Cited by 271 · see citing works

Genome-Wide Association Studies of the Human Gut Microbiota

Davenport, E., Cusanovich, D. A., Michelini, K., Barreiro, L. B., Ober, C., & Gilad, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140301 · Cited by 253 · see citing works

The human gastric microbiota: Is it time to rethink the pathogenesis of stomach diseases?

Nardone, G., & Compare, D. (2015) · United European Gastroenterology Journal · doi:10.1177/2050640614566846 · Cited by 251 · see citing works

The small intestine microbiota, nutritional modulation and relevance for health

El Aidy, S., van den Bogert, B., & Kleerebezem, M. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.09.005 · Cited by 244 · see citing works

Fecal microbiota transplantation as novel therapy in gastroenterology: A systematic review

Rossen, N. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i17.5359 · Cited by 243 · see citing works

Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability

Yuhan, R., Koutsouris, A., Savkovic, S., & Hecht, G. A. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70006-4 · Cited by 239 · see citing works

Cathelicidin Mediates Innate Intestinal Defense against Colonization with Epithelial Adherent Bacterial Pathogens

Iimura, M., Gallo, R. L., Hase, K., Miyamoto, Y., Eckmann, L., & Kagnoff, M. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4901 · Cited by 236 · see citing works

Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice

Savignac, H. M., Couch, Y., Stratford, M., Bannerman, D. M., Tzortzis, G., Anthony, D. C., & Burnet, P. W. J. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.10.007 · Cited by 223 · see citing works

Mucin Degradation by Bifidobacterium Strains Isolated from the Human Intestinal Microbiota

Ruas‐Madiedo, P., Gueimonde, M., Fernández-García, M., Reyes‐Gavilán, C. G. D. L., & Margollés, A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02509-07 · Cited by 222 · see citing works

The study on the impact of glycated pea proteins on human intestinal bacteria

Swiatecka, D., Narbad, A., Ridgway, K. P., & Kostyra, H. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.01.002 · Cited by 219 · see citing works

Capturing the diversity of the human gut microbiota through culture-enriched molecular profiling

Lau, J. Y. F., Whelan, F., Herath, I., Lee, C., Collins, S. M., Berčík, P., & Surette, M. G. (2016) · Genome Medicine · doi:10.1186/s13073-016-0327-7 · Cited by 219 · see citing works

Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin

Saitoh, Y., Suzuki, H., Tani, K., Nishikawa, K., Irie, K., Ogura, Y., Tamura, A., Tsukita, S., & Fujiyoshi, Y. (2015) · Science · doi:10.1126/science.1261833 · Cited by 205 · see citing works

Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function

Anderson, R. C., Cookson, A. L., McNabb, W. C., Kelly, W. J., & Roy, N. C. (2010) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2010.02038.x · Cited by 194 · see citing works

Clostridium difficile toxin B disrupts the barrier function of T84 monolayers

Hecht, G. A., Koutsouris, A., Pothoulakis, C., LaMont, J. T., & Madara, J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90085-d · Cited by 191 · see citing works

Gut Microbiota Community and Its Assembly Associated with Age and Diet in Chinese Centenarians

Fang, W., Yu, T., Huang, G., Cai, D., Liang, X., Su, H., Zhu, Z., Li, D., Yang, Y., Shen, P., et al. (2015) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1410.10014 · Cited by 184 · see citing works

The Impact of the Milk Glycobiome on the Neonate Gut Microbiota

Pacheco, A. R., Barile, D., Underwood, M. A., & Mills, D. A. (2014) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022114-111112 · Cited by 181 · see citing works

Energy‑dense diet triggers changes in gut microbiota, reorganization of gut‑brain vagal communication and increases body fat accumulation

C. Vaughn, A., M. Cooper, E., M. DiLorenzo, P., J. O’Loughlin, L., E. Konkel, M., H. Peters, J., Hajnal, A., Sen, T., Hye Lee, S., B. de La Serre, C., et al. (2017) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2017-033 · Cited by 166 · see citing works

Systematic review with meta-analysis: long-term outcomes of faecal microbiota transplantation for Clostridium difficile infection

Li, Y., Cai, H., Wang, Z.-H., Xu, J., & Fang, J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13492 · Cited by 156 · see citing works

Gut bacterial diversity of the tribes of India and comparison with the worldwide data

Dehingia, M., Kanchal, T., Talukdar, N. C., Talukdar, R., Reddy, D. N., Mande, S. S., Deka, M., & Khan, M. R. (2015) · Scientific Reports · doi:10.1038/srep18563 · Cited by 146 · see citing works

Effect of Probiotics on Blood Lipid Concentrations: A Meta-Analysis of Randomized Controlled Trials

Cho, Y. A., & Kim, J. (2015) · Medicine · doi:10.1097/md.0000000000001714 · Cited by 143 · see citing works

Regulation of macrophage activation and inflammation by spermine: A new chapter in an old story

Zhang, M., Wang, H., & Tracey, K. J. (2000) · Critical Care Medicine · doi:10.1097/00003246-200004001-00007 · Cited by 142 · see citing works

Germ-free and Colonized Mice Generate the Same Products from Enteric Prodefensins

Pütsep, K., Axelsson, L.-G., Boman, A., Midtvedt, T., Normark, S. J., Boman, H. G., & Andersson, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007816200 · Cited by 140 · see citing works

Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women

Most, J., Penders, J., Lucchesi, M., Goossens, G. H., & Blaak, E. E. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2017.89 · Cited by 138 · see citing works

The meaning and impact of the human genome sequence for microbiology

Relman, D. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(01)02041-8 · Cited by 136 · see citing works

Role of Extracellular Transaldolase from Bifidobacterium bifidum in Mucin Adhesion and Aggregation

González-Rodríguez, I., Sánchez, B., Ruíz, L., Turroni, F., Ventura, M., Ruas‐Madiedo, P., Gueimonde, M., & Margollés, A. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.08024-11 · Cited by 123 · see citing works

Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection

Weingarden, A. R., Chen, C., Zhang, N., Graiziger, C. T., Dosa, P. I., Steer, C. J., Shaughnessy, M. K., Johnson, J. R., Sadowsky, M. J., & Khoruts, A. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000427 · Cited by 122 · see citing works

The Role of the Gut Flora in the Metabolism of Prontosil and Neoprontosil in the Rat

Gingell, R., Bridges, J. W., & Williams, R. T. (1971) · Xenobiotica · doi:10.3109/00498257109044386 · Cited by 117 · see citing works

Effect of a high-beef diet on the fecal bacterial flora of humans.

Hentges, D. J., Maier, B. R., Burton, G. C., Flynn, M. A., & Tsutakawa, R. K. (1977) · PubMed · Cited by 114 · see citing works

Effect of four probiotic strains and Escherichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression

Putaala, H., Salusjärvi, T., Nordström, M., Saarinen, M., Ouwehand, A. C., Hansen, E. B., & Rautonen, N. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2008.08.002 · Cited by 111 · see citing works

Interindividual variability in the human metabolism of ellagic acid: Contribution of Gordonibacter to urolithin production

Romo‐Vaquero, M., Garcı́a-Villalba, R., González‐Sarrías, A., Beltrán, D., Tomás-Barberán, F. A., Espı́n, J. C., & Selma, M. V. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.040 · Cited by 109 · see citing works

Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome

de Cossío, L. F., Fourrier, C., Sauvant, J., Everard, A., Capuron, L., Cani, P. D., Layé, S., & Castanon, N. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.12.022 · Cited by 108 · see citing works

Pic, an Autotransporter Protein Secreted by Different Pathogens in theEnterobacteriaceaeFamily, Is a Potent Mucus Secretagogue

Navarro‐García, F., Gutiérrez-Jiménez, J., García-Tovar, C. G., Castro‐Sánchez, L., Salazar-González, H., & Cordova, V. (2010) · Infection and Immunity · doi:10.1128/iai.00523-10 · Cited by 104 · see citing works

Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice

Selwyn, F. P., Csanaky, I. L., Zhang, Y., & Klaassen, C. D. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.065276 · Cited by 96 · see citing works

Dynamics of predominant microbiota in the human gastrointestinal tract and change in luminal enzymes and immunoglobulin profile during high-altitude adaptation

Adak, A., Maity, C., Ghosh, K., Pati, B. R., & Mondal, K. C. (2013) · Folia Microbiologica · doi:10.1007/s12223-013-0241-y · Cited by 94 · see citing works

Dynamics of the Vaginal Ecosystem—Hormonal Influences

Farage, M. A., Miller, K. W., & Sobel, J. D. (2010) · Infectious Diseases Research and Treatment · doi:10.4137/idrt.s3903 · Cited by 92 · see citing works

Neonatal prebiotic (BGOS) supplementation increases the levels of synaptophysin, GluN2A-subunits and BDNF proteins in the adult rat hippocampus

Williams, S., Chen, L., Savignac, H. M., Tzortzis, G., Anthony, D. C., & Burnet, P. W. J. (2015) · Synapse · doi:10.1002/syn.21880 · Cited by 91 · see citing works

Influence of breast milk polyamines on suckling rat immune system maturation

Pérez-Cano, F. J., González-Castro, A. M., Castellote, C., Franch, À., & Castell, M. (2009) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2009.10.001 · Cited by 82 · see citing works

Diversity and enterotype in gut bacterial community of adults in Taiwan

Liang, C., Tseng, H., Chen, H., Wang, W.-C., Chiu, C.-M., Chang, J.-Y., Lu, K., Weng, S.-L., Chang, T., Chang, C.-H., et al. (2017) · BMC Genomics · doi:10.1186/s12864-016-3261-6 · Cited by 78 · see citing works

Impact of dietary fiber and fat on gut microbiota re-modeling and metabolic health

Benítez‐Páez, A., del Pulgar, E. M. G., Kjølbæk, L., Brahe, L. K., Astrup, A. V., Larsen, L. H., & Sanz, Y. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.11.001 · Cited by 76 · see citing works

Starter formula enriched in prebiotics and probiotics ensures normal growth of infants and promotes gut health: a randomized clinical trial

Radke, M. H., Picaud, J., Loui, A., Cambonie, G., Faas, D., Lafeber, H. N., de Groot, N., Pecquet, S., Steenhout, P. G., & Hascoët, J. (2016) · Pediatric Research · doi:10.1038/pr.2016.270 · Cited by 75 · see citing works

Alteration of Predominant Gastrointestinal Flora and Oxidative Damage of Large Intestine Under Simulated Hypobaric Hypoxia

Adak, A., Maity, C., Ghosh, K., & Mondal, K. C. (2014) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0033-1336007 · Cited by 67 · see citing works

Impact of probiotic Saccharomyces boulardii on the gut microbiome composition in HIV-treated patients: A double-blind, randomised, placebo-controlled trial

Villar-García, J., Güerri‐Fernández, R., Moyá, A., González, A., Hernández, J. J., Lerma, E., Guelar, A., Sorlí, L., Horcajada, J. P., Artacho, A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173802 · Cited by 66 · see citing works

The regulatory effects of whey retentate from Bifidobacteria fermented milk on the microbiota of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME)

Meddah, A. T. T., Yazourh, A., Desmet, I., Risbourg, B., Verstraete, W., & Romond, M. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01482.x · Cited by 59 · see citing works

Long‐term safety and efficacy of perinatal probiotic intervention: Evidence from a follow‐up study of four randomized, double‐blind, placebo‐controlled trials

Lundelin, K., Poussa, T., Salminen, S., & Isolauri, E. (2017) · Pediatric Allergy and Immunology · doi:10.1111/pai.12675 · Cited by 56 · see citing works

In a Map for Human Life, Count the Microbes, Too

DAVIES, J. E. (2001) · Science · doi:10.1126/science.291.5512.2316b · Cited by 50 · see citing works

Different Roles for Lactococcal Aggregation Factor and Mucin Binding Protein in Adhesion to Gastrointestinal Mucosa

Lukić, J., Strahinić, I., Jovčić, B., Filipić, B., Topisirović, L., Kojić, M., & Begović, J. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.02141-12 · Cited by 50 · see citing works

Genetic and Transcriptional Analysis of Human Host Response to Healthy Gut Microbiota

Richards, A. L., Burns, M. B., Alazizi, A., Barreiro, L. B., Piqué-Regi, R., Blekhman, R., & Luca, F. (2016) · mSystems · doi:10.1128/msystems.00067-16 · Cited by 49 · see citing works

Behavioural and cognitive effects of oligofructose-enriched inulin in rats

Messaoudi, M., Rozan, P., Nejdi, A., Hidalgo, S., & Desor, D. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041348 · Cited by 39 · see citing works

Microbiome: Ecology of stable gut communities

McNally, L., & Brown, S. P. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2015.16 · Cited by 31 · see citing works

Cultural Divergence: Elie Metchnikoff's Bacillus bulgaricus Therapy and His Underlying Concept of Health

Podolsky, S. H. (1998) · Bulletin of the history of medicine · doi:10.1353/bhm.1998.0056 · Cited by 31 · see citing works

Converging on a mechanism for choline degradation

Thibodeaux, C. J., & van der Donk, W. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219534110 · Cited by 28 · see citing works

Dietary fat‐induced taurocholic acid production promotes pathobiont and colitis in IL‐10−/− mice

Devkota, S., Wang, Y., Leone, V., Musch, M. W., Nadimpalli, A., Antonopoulos, D., Jabrì, B., & Chang, E. B. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.1155.2 · Cited by 25 · see citing works

Modulation of small intestinal homeostasis along with its microflora during acclimatization at simulated hypobaric hypoxia.

Adak, A., Ghosh, K., & Mondal, K. C. (2014) · PubMed · Cited by 22 · see citing works

Dietary prebiotics improve memory and social interactions while reducing anxiety when provided early in life to normally developing rodents (637.5)

Waworuntu, R. V., Hain, H. S., Chang, Q., Thiede, L., Hanania, T., & Berg, B. M. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.637.5 · Cited by 14 · see citing works

Ethnicity influences gut metabolites and microbiota of the tribes of Assam, India

Dehingia, M., Sen, S., Bhaskar, B., Joishy, T. K., Deka, M., Talukdar, N. C., & Khan, M. R. (2017) · Metabolomics · doi:10.1007/s11306-017-1206-y · Cited by 11 · see citing works

43 Dietary Fat-Induced Taurocholic Acid Production Promotes Pathobiont and Colitis in IL-10-/- Mice

Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabrì, B., & Chang, E. B. (2012) · Gastroenterology · doi:10.1016/s0016-5085(12)60043-2 · Cited by 10 · see citing works

[Old and new experiences on therapeutic successes by restoration of the colonic flora with mutaflor in gastrointestinal diseases].

Nissle, A. (1961) · PubMed · Cited by 7 · see citing works

Effect of Diet and Dietary Components on the Composition of the Gut Microbiota

Beam, A., Clinger, E., & Hao, L. (2021) · Nutrients · doi:10.3390/nu13082795 · Cited by 576 · see citing works

Intestinal Barrier in Human Health and Disease

Tommaso, N. D., Gasbarrini, A., & Ponziani, F. R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182312836 · Cited by 541 · see citing works

Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders

Chopyk, D. M., & Grakoui, A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.04.077 · Cited by 495 · see citing works

Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

Montero, C. G., Fraile‐Μartinez, O., Gomez-Lahoz, A. M., Pekarek, L., Castellanos, A. J., Noguerales-Fraguas, F., Coca, S., Guijarro, L. G., García‐Honduvilla, N., Asúnsolo, Á., et al. (2021) · Nutrients · doi:10.3390/nu13020699 · Cited by 452 · see citing works

The interaction among gut microbes, the intestinal barrier and short chain fatty acids

Ma, J., Piao, X., Mahfuz, S. U., Long, S., & Wang, J. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.09.012 · Cited by 409 · see citing works

The links between gut microbiota and obesity and obesity related diseases

Geng, J., Ni, Q., Sun, W., Li, L., & Feng, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112678 · Cited by 410 · see citing works

Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics

Liu, Y., Wang, J., & Wu, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.634897 · Cited by 393 · see citing works

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

Zhao, L.-Y., Mei, J.-X., Yu, G., Lei, L., Zhang, W.-H., Liu, K., Chen, X.-L., Kołat, D., Yang, K., & Hu, J.-K. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01406-7 · Cited by 359 · see citing works

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

Rao, Y., Kuang, Z., Li, C., Guo, S., Xu, Y., Zhao, D., Hu, Y., Song, B., Jiang, Z., Ge, Z., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1927633 · Cited by 356 · see citing works

Human gut microbiome aging clock based on taxonomic profiling and deep learning

Galkin, F., Mamoshina, P., Aliper, A., Lane, E., Moskalev, V., Gladyshev, V. N., & Zhavoronkov, A. (2020) · iScience · doi:10.1016/j.isci.2020.101199 · Cited by 292 · see citing works

Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry

Shehata, A. A., Yalçın, S., Latorre, J. D., Basiouni, S., Attia, Y. A., El‐Wahab, A. A., Visscher, C., El-Seedi, H. R., Huber, C., Hafez, H. M., et al. (2022) · Microorganisms · doi:10.3390/microorganisms10020395 · Cited by 289 · see citing works

Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin

Scazzocchio, B., Minghetti, L., & D’Archivio, M. (2020) · Nutrients · doi:10.3390/nu12092499 · Cited by 282 · see citing works

Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

Campbell, C., Kandalgaonkar, M. R., Golonka, R. M., Yeoh, B. S., Vijay–Kumar, M., & Saha, P. (2023) · Biomedicines · doi:10.3390/biomedicines11020294 · Cited by 256 · see citing works

Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)

Benedé-Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2331460 · Cited by 242 · see citing works

Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

Wang, R., Yang, X., Liu, J., Zhong, F., Zhang, C., Chen, Y., Sun, T., Ji, C., & Ma, D. (2022) · Nature Communications · doi:10.1038/s41467-022-30240-8 · Cited by 233 · see citing works

Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential

Ioannou, A., Berkhout, M. D., Geerlings, S. Y., & Belzer, C. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01106-1 · Cited by 245 · see citing works

Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease

Konopelski, P., & Mogilnicka, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031222 · Cited by 218 · see citing works

The causal role of gut microbiota in development of osteoarthritis

Yu, X., Yang, Y.-Q., Cao, R.-R., Bo, L., & Lei, S.-F. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.08.003 · Cited by 216 · see citing works

Neuroactive compounds in foods: Occurrence, mechanism and potential health effects

Yılmaz, C., & Gökmen, V. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108744 · Cited by 216 · see citing works

Involvement of Probiotics and Postbiotics in the Immune System Modulation

Yeşilyurt, N., Yılmaz, B., Ağagündüz, D., & Capasso, R. (2021) · Biologics · doi:10.3390/biologics1020006 · Cited by 212 · see citing works

Interactive relationships between intestinal flora and bile acids

Guo, X., Okpara, E. S., Hu, W., Yan, C., Wang, Y., Liang, Q., Chiang, J. Y. L., & Han, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158343 · Cited by 206 · see citing works

The gut-liver axis in sepsis: interaction mechanisms and therapeutic potential

Zhang, X., Liu, H., Hashimoto, K., Yuan, S., & Zhang, J. (2022) · Critical Care · doi:10.1186/s13054-022-04090-1 · Cited by 200 · see citing works

Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony

Zhou, P., Chen, C., Patil, S., & Dong, S. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1355542 · Cited by 193 · see citing works

Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases

Battistini, C., Ballan, R., Herkenhoff, M. E., Saad, S. M. I., & Sun, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010362 · Cited by 183 · see citing works

Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics

Li, D. X., Li, Y., Yang, S., Lu, J., Jin, X., & Wu, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113290 · Cited by 186 · see citing works

Plant microbiota dysbiosis and the Anna Karenina Principle

Arnault, G., Mony, C., & Vandenkoornhuyse, P. (2022) · Trends in Plant Science · doi:10.1016/j.tplants.2022.08.012 · Cited by 182 · see citing works

Microbiota–Gut–Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics

Ding, M., Lang, Y., Shu, H., Shao, J., & Cui, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.742449 · Cited by 170 · see citing works

A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine

Xu, H., Zhang, Y., Wang, P., Zhang, J., Chen, H., Zhang, L., Du, X., Zhao, C., Wu, D., Liu, F., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.024 · Cited by 163 · see citing works

Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future perspectives

Islam, M. R., Rauf, A., Akash, S., Trisha, S. I., Nasim, A. H., Akter, M., Dhar, P. S., Ogaly, H. A., Hemeg, H. A., Wilairatana, P., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116034 · Cited by 165 · see citing works

The Role of Gut Microbiota and Gut–Brain Interplay in Selected Diseases of the Central Nervous System

Doroszkiewicz, J., Groblewska, M., & Mroczko, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810028 · Cited by 160 · see citing works

The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review

Mesa, M. D., Loureiro, B., Iglesia, I., Gonzalez, S. F., Llurba, E., García‐Algar, Ó., Solana, M. J., Cabero-Pérez, M. J., Sainz, T., Martínez, L., et al. (2020) · Nutrients · doi:10.3390/nu12010133 · Cited by 146 · see citing works

Gut Microbiota Modulation Through Mediterranean Diet Foods: Implications for Human Health

Perrone, P., & D’Angelo, S. (2025) · Nutrients · doi:10.3390/nu17060948 · Cited by 142 · see citing works

Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome

Hillestad, E. M. R., van der Meeren, A., Nagaraja, B. H., Bjørsvik, B. R., Haleem, N., Benítez‐Páez, A., Sanz, Y., Hausken, T., Lied, G. A., Lundervold, A., et al. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i4.412 · Cited by 145 · see citing works

Prebiotics as a Tool for the Prevention and Treatment of Obesity and Diabetes: Classification and Ability to Modulate the Gut Microbiota

Megur, A., Daliri, E. B., Baltriukienė, D., & Burokas, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116097 · Cited by 146 · see citing works

Gut microbiota in various childhood disorders: Implication and indications

Saeed, N. K., Al‐Beltagi, M., Bediwy, A. S., El-Sawaf, Y., & Toema, O. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i18.1875 · Cited by 147 · see citing works

Hydration Status in Older Adults: Current Knowledge and Future Challenges

Li, S., Xiao, X., & Zhang, X. (2023) · Nutrients · doi:10.3390/nu15112609 · Cited by 132 · see citing works

The impact of environmental pH on the gut microbiota community structure and short chain fatty acid production

Firrman, J., Liu, L., Mahalak, K. K., Tanes, C., Bittinger, K. L., Tu, V., Tolehmurodovich, B. J., Mattei, L. M., Zhang, H., & den Abbeele, P. V. (2022) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiac038 · Cited by 129 · see citing works

Gut bacterial extracellular vesicles: important players in regulating intestinal microenvironment

Liang, X. H., Dai, N., Sheng, K., Lu, H., Wang, J., Chen, L., & Wang, Y. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2134689 · Cited by 128 · see citing works

Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality

Wang, S., Liu, Y., Li, J., Zhao, L., Yan, W., Lin, B., Guo, X., & Wei, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.710165 · Cited by 126 · see citing works

Diarrhea Predominant-Irritable Bowel Syndrome (IBS-D): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms

Altomare, A., Rosa, C. D., Imperia, E., Emerenziani, S., Cicala, M., & Guarino, M. P. L. (2021) · Nutrients · doi:10.3390/nu13051506 · Cited by 132 · see citing works

Caenorhabditis elegans: a model to understand host–microbe interactions

Kumar, A., Baruah, A., Tomioka, M., Iino, Y., Kalita, M. C., & Khan, M. R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03319-7 · Cited by 118 · see citing works

Gut and airway microbiota dysbiosis and their role in COVID-19 and long-COVID

Ancona, G., Alagna, L., Alteri, C., Palomba, E., Tonizzo, A., Pastena, A., Muscatello, A., Gori, A., & Bandera, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1080043 · Cited by 117 · see citing works

The gut microbiota in osteoarthritis: where do we stand and what can we do?

Hao, X., Shang, X., Liu, J., Chi, R., Zhang, J., & Xu, T. (2021) · Arthritis Research & Therapy · doi:10.1186/s13075-021-02427-9 · Cited by 115 · see citing works

The Role of the Microbiome-Brain-Gut Axis in the Pathogenesis of Depressive Disorder

Młynarska, E., Gadzinowska, J., Tokarek, J., Forycka, J., Szuman, A., Franczyk, B., & Rysz, J. (2022) · Nutrients · doi:10.3390/nu14091921 · Cited by 109 · see citing works

The Role of Microbiome in Brain Development and Neurodegenerative Diseases

Nandwana, V., Nandwana, N. K., Das, Y., Saito, M., Panda, T., Das, S., Almaguel, F. A., Hosmane, N. S., & Das, B. C. (2022) · Molecules · doi:10.3390/molecules27113402 · Cited by 113 · see citing works

Gut microbiome mediates the protective effects of exercise after myocardial infarction

Zhou, Q., Deng, J., Pan, X., Meng, D., Zhu, Y., Bai, Y., Shi, C., Duan, Y., Wang, T., Li, X., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01271-6 · Cited by 106 · see citing works

A Comprehensive Review of the Triangular Relationship among Diet–Gut Microbiota–Inflammation

Randeni, N., Bordiga, M., & Xu, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179366 · Cited by 104 · see citing works

Opening the doors of precision medicine: novel tools to assess intestinal barrier in inflammatory bowel disease and colitis-associated neoplasia

Iacucci, M., Santacroce, G., Majumder, S., Morael, J., Zammarchi, I., Maeda, Y., Ryan, D., Sabatino, A. D., Rescigno, M., Aburto, M. R., et al. (2024) · Gut · doi:10.1136/gutjnl-2023-331579 · Cited by 103 · see citing works

The hypothalamus for whole-body physiology: from metabolism to aging

Liu, T., Xu, Y., Yi, C., Tong, Q., & Cai, D. (2021) · Protein & Cell · doi:10.1007/s13238-021-00834-x · Cited by 103 · see citing works

An Insight into Diversity and Functionalities of Gut Microbiota in Insects

Wang, S., Wang, L., Fan, X., Yu, C., Feng, L., & Li, Y. (2020) · Current Microbiology · doi:10.1007/s00284-020-02084-2 · Cited by 98 · see citing works

The gut microbiota–brain axis in neurological disorders

You, M., Chen, N., Yang, Y., Cheng, L., He, H., Cai, Y., Liu, Y., Liu, H., & Hong, G. (2024) · MedComm · doi:10.1002/mco2.656 · Cited by 107 · see citing works

The Immunomodulatory Effect of the Gut Microbiota in Kidney Disease

Chi, M., Ma, K., Wang, J., Ding, Z., Li, Y., Zhu, S., Liang, X., Zhang, Q., Song, L., & Liu, C. (2021) · Journal of Immunology Research · doi:10.1155/2021/5516035 · Cited by 98 · see citing works

Polyethylene microplastics induced gut microbiota dysbiosis leading to liver injury via the TLR2/NF-κB/NLRP3 pathway in mice

Xu, R., Cao, J.-W., Lv, H.-L., Yuan, G., & Guo, M. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.170518 · Cited by 98 · see citing works

Impact of the Gut Microbiota Balance on the Health–Disease Relationship: The Importance of Consuming Probiotics and Prebiotics

Olvera-Rosales, L. B., Cruz-Guerrero, A. E., Ramírez‐Moreno, E., Lira, A. Q., Contreras‐López, E., Ordaz, J. J., Ovando, A. C., Añorve‐Morga, J., Calderón‐Ramos, Z. G., Arias‐Rico, J., et al. (2021) · Foods · doi:10.3390/foods10061261 · Cited by 101 · see citing works

The Maternal–Fetal Gut Microbiota Axis: Physiological Changes, Dietary Influence, and Modulation Possibilities

Mikó, É., Csaszar, A., Bódis, J., & Kovács, K. A. (2022) · Life · doi:10.3390/life12030424 · Cited by 98 · see citing works

Novel potential pharmacological applications of dimethyl fumarate—an overview and update

Bresciani, G., Manai, F., Davinelli, S., Tucci, P., Saso, L., & Amadio, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1264842 · Cited by 85 · see citing works

Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis

Dou, Y., Yu, X., Luo, Y., Chen, B., Ma, D., & Zhu, J. (2022) · Nutrients · doi:10.3390/nu14163298 · Cited by 99 · see citing works

Emerging role of gut microbiota in autoimmune diseases

Wang, X., Yuan, W., Yang, C., Wang, Z., Zhang, J., Xu, D., Sun, X., & Sun, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1365554 · Cited by 101 · see citing works

Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition

Albouery, M., Buteau, B., Gregoire, S., Cherbuy, C., de Barros, J.-P. P., Martine, L., Chain, F., Cabaret, S., Berdeaux, O., Bron, A. M., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00444 · Cited by 87 · see citing works

Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota

Micheli, L., Bertini, L., Bonato, A., Villanova, N., Caruso, C., Caruso, M., Bernini, R., & Tirone, F. (2023) · Nutrients · doi:10.3390/nu15071767 · Cited by 85 · see citing works

The Postbiotic Properties of Butyrate in the Modulation of the Gut Microbiota: The Potential of Its Combination with Polyphenols and Dietary Fibers

Maiuolo, J., Bulotta, R. M., Ruga, S., Nucera, S., Macrì, R., Scarano, F., Oppedisano, F., Carresi, C., Gliozzi, M., Musolino, V., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136971 · Cited by 85 · see citing works

Microbiota-Host-Irinotecan Axis: A New Insight Toward Irinotecan Chemotherapy

Yue, B., Gao, R., Wang, Z., & Dou, W. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.710945 · Cited by 84 · see citing works

Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?

Mamieva, Z. A., Poluektova, E. A., Свистушкин, В. М., Sobolev, V., Shifrin, O. S., Guarner, F., & Ivashkin, V. T. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i12.1204 · Cited by 85 · see citing works

Bioactive peptides of whey: obtaining, activity, mechanism of action, and further applications

Olvera-Rosales, L. B., Cruz-Guerrero, A. E., García-Garibay, J. M., Gómez‐Ruiz, L., Contreras‐López, E., Guzmán‐Rodríguez, F., & González-Olivares, L. G. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2079113 · Cited by 87 · see citing works

Intestinal mucus barrier: A potential therapeutic target for IBD

Qiao, Y., He, C., Xia, Y., Ocansey, D. K. W., & Mao, F. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103717 · Cited by 80 · see citing works

Gut Microbiota: the Emerging Link to Lung Homeostasis and Disease

Zhou, A., Lei, Y., Tang, L., Hu, S., Yang, M., Wu, L., Yang, S., & Tang, B. (2020) · Journal of Bacteriology · doi:10.1128/jb.00454-20 · Cited by 78 · see citing works

Pb Toxicity on Gut Physiology and Microbiota

Liu, W., Feng, H., Zheng, S., Xu, S., Massey, I. Y., Zhang, C., Wang, X., & Yang, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.574913 · Cited by 77 · see citing works

Microbial metabolites in colorectal tumorigenesis and cancer therapy

Liu, Y., Lau, H. C.-H., & Yu, J. Q. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2203968 · Cited by 80 · see citing works

Review: The Role of Intestinal Dysbiosis in Parkinson’s Disease

Huang, Y., Liao, J., Liu, X., Zhong, Y., Cai, X., & Long, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.615075 · Cited by 77 · see citing works

Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases

Martemucci, G., Fracchiolla, G., Muraglia, M., Tardugno, R., Dibenedetto, R. S., & D‘Alessandro, A. G. (2023) · Antioxidants · doi:10.3390/antiox12122091 · Cited by 81 · see citing works

When a Neonate Is Born, So Is a Microbiota

Coscia, A., Bardanzellu, F., Caboni, E., Fanos, V., & Peroni, D. G. (2021) · Life · doi:10.3390/life11020148 · Cited by 76 · see citing works

MDG, an Ophiopogon japonicus polysaccharide, inhibits non-alcoholic fatty liver disease by regulating the abundance of Akkermansia muciniphila

Zhang, L. R., Wang, Y., Wu, F., Wang, X., Feng, Y., & Wang, Y. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.12.036 · Cited by 73 · see citing works

The oral-gut microbiota axis: a link in cardiometabolic diseases

Xu, Q., Wang, W., Li, Y., Cui, J., Zhu, M., Liu, Y., & Liu, Y. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00646-5 · Cited by 75 · see citing works

From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

Zhou, Z., Long, H., Cheng, Y., Luo, H., Wen, D., & Gao, L. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.767931 · Cited by 76 · see citing works

Gut Dysbiosis and Kidney Diseases

Cao, C., Zhu, H. J., Yao, Y., & Zeng, R. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.829349 · Cited by 75 · see citing works

Gut microbiota mediated hypoglycemic effect of Astragalus membranaceus polysaccharides in db/db mice

Song, Q., Cheng, S. W., Li, D., Cheng, H., Lai, Y. S., Han, Q., Wu, H. Y., Shaw, P. C., & Zuo, Z. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1043527 · Cited by 73 · see citing works

Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics

Wei, Z., Li, F., & Pi, G.-F. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.812596 · Cited by 73 · see citing works

Gut microbiota supports male reproduction via nutrition, immunity, and signaling

Cai, H., Cao, X.-H., Qin, D., Liu, Y.-D., Liu, Y., Hua, J., & Peng, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.977574 · Cited by 65 · see citing works

Probiotics for the treatment of depression and its comorbidities: A systemic review

Gao, J., Zhao, N., Cheng, Y., Lei, W., Wang, Y., Liu, X., Zheng, N., Shao, L., Chen, X., Sun, Y., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1167116 · Cited by 75 · see citing works

Approach to the diagnosis and management of dysbiosis

Alagiakrishnan, K., Morgadinho, J., & Halverson, T. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1330903 · Cited by 74 · see citing works

Gut microbial changes of patients with psychotic and affective disorders: A systematic review

Vindegaard, N., Speyer, H., Nordentoft, M., Rasmussen, S., & Benros, M. E. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2019.12.014 · Cited by 66 · see citing works

Recent advances in modulating the microbiome

Quigley, E. M. M., & Gajula, P. (2020) · F1000Research · doi:10.12688/f1000research.20204.1 · Cited by 68 · see citing works

Comparison of Metagenomics and Metatranscriptomics Tools: A Guide to Making the Right Choice

Terron-Camero, L. C., Gordillo-González, F., Salas‐Espejo, E., & Andrés‐León, E. (2022) · Genes · doi:10.3390/genes13122280 · Cited by 71 · see citing works

Regulation of Gut Microbiota on Immune Reconstitution in Patients With Acquired Immunodeficiency Syndrome

Geng, S.-T., Zhang, Z., Wang, Y.-X., Lu, D., Yu, J., Zhang, J., Kuang, Y., & Wang, K. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.594820 · Cited by 63 · see citing works

Exopolysaccharides from lactic acid bacteria, as an alternative to antibiotics, on regulation of intestinal health and the immune system

Yang, S., Xu, X., Peng, Q., Ma, L., Qiao, Y., & Shi, B. (2023) · Animal nutrition · doi:10.1016/j.aninu.2023.02.004 · Cited by 65 · see citing works

Modulating the gut microbiota by probiotics, prebiotics, postbiotics, and fecal microbiota transplantation: An emerging trend in cancer patient care

Čierniková, S., Ševčíková, A., Drgoňa, Ľ., & Mego, M. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188990 · Cited by 68 · see citing works

Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites

Zhang, W., Dong, X. Y., & Huang, R. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01096-3 · Cited by 66 · see citing works

Occurrence and exposure assessment of glyphosate in the environment and its impact on human beings

Muñoz, J. P., Silva-Pavez, E., Carrillo-Beltrán, D., & Calaf, G. M. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116201 · Cited by 64 · see citing works

Gut microbiota is involved in male reproductive function: a review

Lv, S., Huang, J., Luo, Y., Wen, Y., Chen, B., Qiu, H., Chen, H., Yue, T., He, L., Feng, B., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1371667 · Cited by 65 · see citing works

Gut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids

Shen, H., Zhang, C., Zhang, Q., Lv, Q., Liu, H., Yuan, H., Wang, C., Meng, F., Guo, Y., Pei, J., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03282-6 · Cited by 67 · see citing works

Alterations of the gut microbiota and metabolomics in children with e-waste lead exposure

Zeng, X., Zeng, Z., Wang, Q., Liang, W., Guo, Y., & Huo, X. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128842 · Cited by 63 · see citing works

Research Progress for Probiotics Regulating Intestinal Flora to Improve Functional Dyspepsia: A Review

Shen, X., Xie, A., Li, Z., Jiang, C., Wu, J., Li, M., & Yue, X. (2024) · Foods · doi:10.3390/foods13010151 · Cited by 63 · see citing works

Alteration of Gut Microbiota: New Strategy for Treating Autism Spectrum Disorder

Liu, J., Gao, Z., Chuanqi, L., Liu, T., Gao, J., Cai, Y., & Fan, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.792490 · Cited by 62 · see citing works

The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy

Poto, R., Fusco, W., Rinninella, E., Cintoni, M., Kaitsas, F., Raoul, P. C., Caruso, C., Mele, M. C., Varricchi, G., Gasbarrini, A., et al. (2023) · Nutrients · doi:10.3390/nu16010092 · Cited by 67 · see citing works

Recent advances in prebiotics: Classification, mechanisms, and health applications

Ali, S., Hamayun, M., Siraj, M., Khan, S. A., Kim, H., & Lee, B. (2025) · Future Foods · doi:10.1016/j.fufo.2025.100680 · Cited by 62 · see citing works

Comparison of Different Soluble Dietary Fibers during the In Vitro Fermentation Process

Bai, J., Li, Y., Li, T., Zhang, W., Fan, M., Zhang, K., Qian, H., Zhang, H., Qi, X., & Wang, L. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c00237 · Cited by 61 · see citing works

Extraction, purification, structural characteristics, biological activities, and application of the polysaccharides from Nelumbo nucifera Gaertn. (lotus): A review

Wang, M., Hu, W., Wang, Q., Yang, B., & Kuang, H. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.12.072 · Cited by 61 · see citing works

Emerging role of bacterial outer membrane vesicle in gastrointestinal tract

Tian, C., Yang, M., Xu, H., Zhu, M., Zhang, Y., Yao, J., Wang, L., Liang, Y.-J., & Li, D. (2023) · Gut Pathogens · doi:10.1186/s13099-023-00543-2 · Cited by 61 · see citing works

Research advance about plant polysaccharide prebiotics, benefit for probiotics on gut homeostasis modulation

Liu, X., Su, S., Yao, J., Zhang, X., Wu, Z., Jia, L., Liu, L., Hou, R., Farag, M. A., & Liu, L. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103831 · Cited by 64 · see citing works

Exploring the Probiotic Potential of Bacteroides spp. Within One Health Paradigm

Tufail, M. A., & Schmitz, R. A. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10370-9 · Cited by 61 · see citing works

The human gut microbiome in health: Establishment and resilience of microbiota over a lifetime

Greenhalgh, K., Meyer, K. M., Aagaard, K. M., & Wilmes, P. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13318 · Cited by 218 · see citing works

Envisioning emerging frontiers on human gut microbiota and its applications

Ventura, M., Milani, C., Turroni, F., & van Sinderen, D. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13671 · Cited by 4 · see citing works

The gut Microbiome in adult and pediatric functional gastrointestinal disorders

Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163 · see citing works

The Human Gut Microbiota in all its States: From Disturbance to Resilience

Tap, J., Ruppé, É., & Derrien, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00039-5 · Cited by 8 · see citing works

Linking the gut microbiota to human health

Robles, V., & Guarner, F. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114512005235 · Cited by 307 · see citing works