Tropisetron inhibits the antinociceptive effect of intrathecally administered paracetamol and serotonin
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The involvement of the serotonergic pathway in paracetamol action stems from increasing 5-TH levels in central structures and activating spinal 5-TH receptors.
“The involvement of the serotonergic pathway in paracetamol action was reported to stem from increasing 5-TH levels in the central structures and activating the spinal 5-TH receptors.60–71”
Selective blockade of particular serotonergic receptors abolishes the analgesic actions of paracetamol in acute models of pain.
“Decades of research have provided evidence on the significance of this pathway to mediate the analgesic action of paracetamol as it has been shown that selective blockade of particular serotonergic receptors to abolish the analgesic actions of paracetamol in acute models of pain.”
From Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action (2021) · cites this paper as [74]
Cites
FLOWER, R. J., & VANE, J. R. (1972) · Nature · doi:10.1038/240410a0 · Cited by 779 · see citing works
Malmberg, A. B., & Yaksh, T. L. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10314-5 · Cited by 652 · see citing works
Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P
Björkman, R., Hallman, K. M., Hedner, J. A., Hedner, T., & Henning, M. (1994) · Pain · doi:10.1016/0304-3959(94)90001-9 · Cited by 241 · see citing works
Antinociceptive effect of paracetamol in rats is partly dependent on spinal serotonergic systems
Tjølsen, A., Lund, A., & Hole, K. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90036-p · Cited by 163 · see citing works
The 5-HT4 receptor: naughty, but nice
Clarke, D. E., Craig, D. A., & Fozard, J. R. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90177-6 · Cited by 158 · see citing works
Glaum, S. R., Proudfit, H. K., & Anderson, E. G. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90677-5 · Cited by 124 · see citing works
Identification of 5-HT3 binding sites in rat spinal cord synaptosomal membranes
Glaum, S. R., & Anderson, E. G. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90335-4 · Cited by 69 · see citing works
Evidence of a central antinociceptive effect of paracetamol involving spinal 5HT3 receptors
Pélissier, T., Alloui, A., Paeile, C., & Eschalier, A. (1995) · Neuroreport · doi:10.1097/00001756-199507310-00020 · Cited by 61 · see citing works
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Graham, G. G., Davies, M. J., Day, R. O., Mohamudally, A., & Scott, K. F. (2013) · Inflammopharmacology · doi:10.1007/s10787-013-0172-x · Cited by 671 · see citing works
Analgesic effect of acetaminophen in humans: First evidence of a central serotonergic mechanism
PICKERING, G., LORIOT, M., LIBERT, F., ESCHALIER, A., BEAUNE, P., & DUBRAY, C. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.12.307 · Cited by 283 · see citing works
Self-citationParacetamol (acetaminophen): A familiar drug with an unexplained mechanism of action
Ayoub, S. S. (2021) · Temperature · doi:10.1080/23328940.2021.1886392 · Cited by 223 · see citing works
Acetaminophen Reinforces Descending Inhibitory Pain Pathways
Pickering, G., Estève, V, Loriot, M.-A., Eschalier, A., & Dubray, C. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100403 · Cited by 168 · see citing works
Self-citationTRPV1 in Brain Is Involved in Acetaminophen-Induced Antinociception
Mallet, C., Barrière, D. A., Ermund, A., Jönsson, B. A. G., Eschalier, A., Zygmunt, P. M., & Högestätt, E. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012748 · Cited by 165 · see citing works
“Interestingly, there is extensive evidence in the literature that the analgesic effect of acetaminophen in both animals and man is dependent on bulbospinal serotonergic pathways [8,31–35].”
BackgroundSelf-citationAcetaminophen Inhibits Spinal Prostaglandin E2Release after Peripheral Noxious Stimulation
Muth-Selbach, U. S., Tegeder, I., Brune, K., & Geisslinger, G. (1999) · Anesthesiology · doi:10.1097/00000542-199907000-00032 · Cited by 142 · see citing works
Toussaint, K., Yang, X. C., Zielinski, M. A., Reigle, K. L., Sacavage, S. D., Nagar, S., & Raffa, R. B. (2010) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2009.01143.x · Cited by 135 · see citing works
Alloui, A., Chassaing, C., Schmidt, J., Ardid, D., Dubray, C., Cloarec, A., & Eschalier, A. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01578-9 · Cited by 83 · see citing works
Self-citationMallet, C., Desmeules, J., Pegahi, R., & Eschalier, A. (2023) · Journal of Pain Research · doi:10.2147/jpr.s393809 · Cited by 83 · see citing works
Self-citationPhenacetin, acetaminophen and dipyrone: analgesic and rewarding effects
Abbott, F. V., & Hellemans, K. G. C. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00179-0 · Cited by 72 · see citing works
Bonnefont, J., Alloui, A., Chapuy, E., Clottes, E., & Eschalier, A. (2003) · Anesthesiology · doi:10.1097/00000542-200310000-00034 · Cited by 74 · see citing works
Self-citationPharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?
Esh, C. J., Chrismas, B. C. R., Mauger, A. R., & Taylor, L. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.835 · Cited by 38 · see citing works
The brain signature of paracetamol in healthy volunteers: a double-blind randomized trial
Pickering, G., Kastler, A., Macian, N., Pereira, B., Valabregue, R., Lehericy, S., Boyer, L., Dubray, C., & Jean, B. (2015) · Drug Design, Development and Therapy · doi:10.2147/dddt.s81004 · Cited by 22 · see citing works
Self-citationParacetamol: Update on its Analgesic Mechanism of Action
Mallet, C., Eschalier, A., & Daulhac, L. (2017) · Pain Relief - From Analgesics to Alternative Therapies · doi:10.5772/66649 · Cited by 11 · see citing works
Self-citation
- Authors
- Alloui, A., Pelissier, T., Dubray, C., Lavarenne, J., & Eschalier, A.
- Affiliations
- Université Clermont Auvergne (FR)
- Venue
- Fundamental & Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1996-07-08
- Volume
- 10
- Issue
- 4
- Pages
- 406-407
- ISSN
- 0767-3981 (ISSN-L)
- 1472-8206
- OpenAlex
- W1995549993
- Cited by
- 36
- References
- 8
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2017: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fundamental and Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
- Keywords
- tropisetron, paracetamol, serotonin, antinociception, intrathecal administration, opioid antagonists, analgesia, drug interactions
- MeSH terms
- Tropisetron, Acetaminophen, Animals, Indoles, Injections, Spinal, Male, Pain Measurement, Serotonin, Serotonin Antagonists, Rats, Sprague-Dawley, Pain Threshold, Analgesics, Non-Narcotic, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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