Cited by 83Pain Mechanisms and TreatmentsAnesthesia and Pain ManagementPain Management and Opioid Use

Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats

Alloui, Abdelkrim, Chassaing, Claude, Schmidt, Jeannot, Ardid, Denis, Dubray, Claude, Cloarec, Alix, Eschalier, Alain·2002·European Journal of Pharmacology

Abstract

Experiments were performed in carrageenin-treated rats to study, the antinociceptive and anti-inflammatory effects of paracetamol intravenously (i.v.) or intrathecally (i.t.) injected on rats submitted to a mechanical noxious stimulus. The influence of intrathecal tropisetron, a 5 hydroxytryptamine(3) (5-HT(3)) receptor antagonist, on the antinociceptive effects of paracetamol, was also studied. Paracetamol induced a significant antinociceptive effect after (100, 200 and 300 mg/kg) i.v. and (50, 100 and 200 microg/rat) i.t. injection, but no change occurred on edema volume. The effect of paracetamol was totally inhibited by tropisetron (10 microg/rat, i.t.). The foregoing results demonstrate that, in conditions of inflammatory pain, paracetamol exerts a central antinociceptive effect involving spinal 5-HT(3) receptors, without inducing any anti-inflammatory action. These data, give further arguments to consider paracetamol as a central analgesic drug which must be distinguished from non-steroidal anti-inflammatory drugs (NSAIDs), which justifies the usual combination of paracetamol in post-operative pain.

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Crossref · 10.1016/s0014-2999(02)01578-9

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Authors
Alloui, A., Chassaing, C., Schmidt, J., Ardid, D., Dubray, C., Cloarec, A., & Eschalier, A.
Affiliations
  • Inserm (FR)
  • Bristol-Myers Squibb (France) (FR)
Corresponding author
Alloui, Abdelkrim
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2002-05
Volume
443
Issue
1-3
Pages
71-77
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2140002787
Cited by
83
References
39
Citations by year
2024: 1 · 2023: 3 · 2021: 6 · 2020: 9 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 6
FWCI
1.40
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
paracetamol, antinociception, inflammatory pain, tropisetron, intrathecal administration, carrageenan-induced edema, central analgesia, postoperative pain, nonsteroidal anti-inflammatory drugs
MeSH terms
Tropisetron, Acetaminophen, Animals, Anti-Inflammatory Agents, Non-Steroidal, Drug Interactions, Edema, Indoles, Inflammation, Injections, Intravenous, Injections, Spinal, Male, Pain, Receptors, Serotonin, Rats, Sprague-Dawley, Receptors, Serotonin, 5-HT3, Rats

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