The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Gender and the renin–angiotensin–aldosterone system
Abstract
Premenopausal women are protected to some extent from cardiovascular and kidney diseases. Because this protection weakens after menopause, sex hormones are believed to play an important role in the pathogenesis of cardiovascular and kidney diseases. The cardiovascular system and the kidneys are regulated by the renin–angiotensin–aldosterone system (RAAS), which in turn, appears to be regulated by sex hormones. In general, oestrogen increases angiotensinogen levels and decreases renin levels, angiotensin‐converting enzyme (ACE) activity, AT 1 receptor density, and aldosterone production. Oestrogen also activates counterparts of the RAAS such as natriuretic peptides, AT 2 receptor density, and angiotensinogen (1‐7). Progesterone competes with aldosterone for mineralocorticoid receptor. Less is known about androgens, but testosterone seems to increase renin levels and ACE activity. These effects of sex hormones on the RAAS can explain at least some of the gender differences in cardiovascular and kidney diseases.
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Cites
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Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 281
The “His and Hers” of the Renin-Angiotensin System
Hilliard, L. M., Sampson, A. K., Brown, R. D., & Denton, K. M. (2013) · Current Hypertension Reports · doi:10.1007/s11906-012-0319-y · Cited by 228
Sarzani, R., Giulietti, F., Di Pentima, C., Giordano, P., & Spannella, F. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00189.2020 · Cited by 86
The Renin-Angiotensin-Aldosterone System in Postmenopausal Women: The Promise of Hormone Therapy
Gersh, F. L., O’Keefe, J. H., Lavie, C. J., & Henry, B. M. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2021.08.009 · Cited by 57
Sex-specific long-term blood pressure regulation: Modeling and analysis
Leete, J., & Layton, A. T. (2019) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2018.11.002 · Cited by 58
Metadata
- Authors
- Komukai, K., Mochizuki, S., & Yoshimura, M.
- Venue
- Fundamental & Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2010-11-11
- Volume
- 24
- Issue
- 6
- Pages
- 687-698
- ISSN
- 0767-3981 (ISSN-L)
- 1472-8206
- OpenAlex
- W1509779962
- Cited by
- 291
- References
- 107
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
