The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Calcium homeostasis and modulation of synaptic plasticity in the aged brain
Abstract
Summary: The level of intracellular Ca 2+ plays a central role in normal and pathological signaling within and between neurons. These processes involve a cascade of events for locally raising and lowering cytosolic Ca 2+. As the mechanisms for age‐related alteration in Ca 2+ dysregulation have been illuminated, hypotheses concerning Ca 2+ homeostasis and brain aging have been modified. The idea that senescence is due to pervasive cell loss associated with elevated resting Ca 2+ has been replaced by concepts concerning changes in local Ca 2+ levels associated with neural activity. This article reviews evidence for a shift in the sources of intracellular Ca 2+ characterized by a diminished role for N‐methyl‐D‐aspartate receptors and an increased role for intracellular stores and voltage‐dependent Ca 2+ channels. Physiological and biological models are outlined, which relate a shift in Ca 2+ regulation with changes in cell excitability and synaptic plasticity, resulting in a functional lesion of the hippocampus.
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Cites
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Selective neuronal vulnerability to oxidative stress in the brain
Wang (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00012 · Cited by 1,008
The ageing cortical synapse: hallmarks and implications for cognitive decline
Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965
Calcium signaling and neurodegenerative diseases
Bezprozvanny, I. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.01.001 · Cited by 469
Probing the biology of Alzheimer’s disease in mice
Ashe, K. H., & Zahs, K. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.031 · Cited by 413
Salminen, A., Ojala, J., Kaarniranta, K., Haapasalo, A., Hiltunen, M., & Soininen, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07738.x · Cited by 333
Metadata
- Authors
- Foster, T. C.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2007-02-02
- Volume
- 6
- Issue
- 3
- Pages
- 319-325
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1990378255
- Cited by
- 302
- References
- 73
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
