Selective Induction of LTP and LTD by Postsynaptic [Ca2+]i Elevation
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Selective Induction of LTP and LTD by Postsynaptic [Ca 2+]i Elevation. Long-term potentiation (LTP) and long-term depression (LTD), two prominent forms of synaptic plasticity at glutamatergic afferents to CA1 hippocampal pyramidal cells, are both triggered by the elevation of postsynaptic intracellular calcium concentration ([Ca 2+]i). To understand how one signaling molecule can be responsible for triggering two opposing forms of synaptic modulation, different postsynaptic [Ca 2+]i elevation patterns were generated by a new caged calcium compound nitrophenyl-ethylene glycol-bis(β-aminoethyl ether)- N, N, N′, N′-tetraacetic acid in CA1 pyramidal cells. We found that specific patterns of [Ca 2+]i elevation selectively activate LTP or LTD. In particular, only LTP was triggered by a brief increase of [Ca 2+]i with relatively high magnitude, which mimics the [Ca 2+]i rise during electrical stimulation typically used to induce LTP. In contrast, a prolonged modest rise of [Ca 2+]i reliably induced LTD. An important implication of the results is that both the amplitude and the duration of an intracellular chemical signal can carry significant biological information.
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Nitr-5 can evoke either an enhancement or a depression, depending on the amplitude and the duration of the Ca2+ signal.
“Further studies showed that nitr-5 can evoke either an enhancement or a depression, depending on the amplitude and the duration of the Ca2+ signal (181).”
From Synaptic memory and CaMKII (2023) · cites this paper as [181]
The Results section says earlier nitr-5 experiments produced either LTP (enhancement) or LTD (depression) after brief calcium elevations. But the paper attributes selective effects of calcium-signal amplitude and duration to its experiments with nitrophenyl-EGTA; it says nitr-5 could not produce a very high or prolonged calcium rise. Individual passage page numbers are unavailable in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredBrief large-amplitude signals favor potentiation, whereas more modest long-duration signals favor depression.
“Brief large-amplitude signals favor potentiation, whereas more modest long-duration signals favor depression (181).”
From Synaptic memory and CaMKII (2023) · cites this paper as [181]
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- Authors
- Yang, S.-N., Tang, Y.-G., & Zucker, R. S.
- Affiliations
- University of California, Berkeley (US)
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1999-02-01
- Volume
- 81
- Issue
- 2
- Pages
- 781-787
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1957331510
- Cited by
- 534
- References
- 1
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 13 · 2023: 20 · 2022: 12 · 2021: 12 · 2020: 14 · 2019: 22 · 2018: 16 · 2017: 15 · 2016: 19 · 2015: 21 · 2014: 15 · 2013: 24 · 2012: 16
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Karolinska Institutet
- National Institute of Neurological Disorders and Stroke (NS-15114, R01NS015114)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, long-term depression, postsynaptic calcium, intracellular calcium elevation, synaptic plasticity, CA1 pyramidal neurons, hippocampus, caged calcium, glutamatergic synapses
- MeSH terms
- Animals, Calcium, Chelating Agents, Egtazic Acid, Hippocampus, Intracellular Fluid, Neuronal Plasticity, Photolysis, Synapses, Rats, Sprague-Dawley, Long-Term Potentiation, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques
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