The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Age‐related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF‐like growth factor
Open accessAbstract
Summary: Age‐associated changes in stem cell populations have been implicated in age‐related diseases, including cancer. However, little is known about the underlying molecular mechanisms that link aging to the modulation of adult stem cell populations. Drosophila midgut is an excellent model system for the study of stem cell renewal and aging. Here we describe an age‐related increase in the number and activity of intestinal stem cells (ISCs) and progenitor cells in Drosophila midgut. We determined that oxidative stress, induced by paraquat treatment or loss of catalase function, mimicked the changes associated with aging in the midgut. Furthermore, we discovered an age‐related increase in the expression of PVF2, a Drosophila homologue of human PDGF/VEGF, which was associated with and required for the age‐related changes in midgut ISCs and progenitor cell populations. Taken together, our findings suggest that PDGF/VEGF may play a central role in age‐related changes in ISCs and progenitor cell populations, which may contribute to aging and the development of cancer stem cells.
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Cites
Vascular Endothelial Growth Factor and Angiogenesis
Hoeben, A., Landuyt, B., Highley, M. S., Wildiers, H., Van Oosterom, A. T., & De Bruijn, E. A. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.3 · Cited by 1,824
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362
Cancer and aging: a model for the cancer promoting effects of the aging stroma
Krtolica, A., & Campisi, J. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00053-5 · Cited by 295
Cancer and ageing: a nexus at several levels
Balducci, L., & Ershler, W. B. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1675 · Cited by 250
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JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut
Biteau, B., Hochmuth, C. E., & Jasper, H. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.024 · Cited by 583
Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D. (2020) · Cell · doi:10.1016/j.cell.2020.04.049 · Cited by 541
Clark, R. I., Salazar, A., Yamada, R., Fitz-Gibbon, S., Morselli, M., Alcaraz, J., Rana, A., Rera, M., Pellegrini, M., Ja, W. W., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.004 · Cited by 510
Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila
Buchon, N., Osman, D., David, F. P. A., Yu Fang, H., Boquete, J.-P., Deplancke, B., & Lemaitre, B. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.001 · Cited by 513
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog
Rera, M., Bahadorani, S., Cho, J., Koehler, C. L., Ulgherait, M., Hur, J. H., Ansari, W. S., Lo, T., Jones, D. L., & Walker, D. W. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.013 · Cited by 472
Metadata
- Authors
- Choi, N., Kim, J., Yang, D., Kim, Y., & Yoo, M.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2008-02-13
- Volume
- 7
- Issue
- 3
- Pages
- 318-334
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W2031217639
- Cited by
- 260
- References
- 5
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Choi, N., Kim, J., Yang, D., Kim, Y., & Yoo, M. (2008). Age‐related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF‐like growth factor. Aging Cell. https://doi.org/10.1111/j.1474-9726.2008.00380.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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